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Bcr/Abl fusion protein Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
ImatinibIC50204.0 [1]
ImatinibKi14.0 [1]
DasatinibIC503.0 [1]
NilotinibIC5030.0 [1]
PonatinibIC500.5 [1], 0.9 [2], 1.0 [3]
Methanesulfonic acid;N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamideIC50512.0 [1], 1558.0 [2], 2229.0 [3]
CID 11478363IC501.25 [1]
(2S)-2-Amino-2-methyl-4-[4-(heptyloxy)phenyl]-1-butanolIC503000.0 [1]
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50199.53 [1], 200.0 [2]
4-(2-Fluorobenzoyl)piperazino[4-[4-(3-fluorophenylamino)-6-pyrimidinyl]phenyl] ketoneIC5017.0 [1]
N-[3-[2-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamideIC507.5 [1]
4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[2-(2-pyrrolidin-1-ylpyrimidin-5-yl)ethynyl]benzamideIC501000.0 [1]
4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[2-(2-morpholin-4-ylpyrimidin-5-yl)ethynyl]benzamideIC50300.0 [1], 1000.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(2,4-dichlorobenzoyl)piperazin-1-yl]methanoneIC5014.0 [1], 450.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(3-fluorobenzoyl)piperazin-1-yl]methanoneIC5086.0 [1], 2070.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(3-methoxybenzoyl)piperazin-1-yl]methanoneIC5049200.0 [1], 100000.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(2-chlorobenzoyl)piperazin-1-yl]methanoneIC5084.0 [1], 3410.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(2-bromobenzoyl)piperazin-1-yl]methanoneIC50180.0 [1], 740.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl]methanoneIC502760.0 [1], 94570.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(3,4-difluorobenzoyl)piperazin-1-yl]methanoneIC5083520.0 [1], 100000.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(4-methoxybenzoyl)piperazin-1-yl]methanoneIC50100000.0 [1]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(3-methylbenzoyl)piperazin-1-yl]methanoneIC502370.0 [1], 100000.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(4-chlorobenzoyl)piperazin-1-yl]methanoneIC501890.0 [1], 65630.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(2-methoxybenzoyl)piperazin-1-yl]methanoneIC5022760.0 [1], 100000.0 [2]
[4-(3-Amino-1H-indazol-4-yl)phenyl]-[4-(2-methylbenzoyl)piperazin-1-yl]methanoneIC508560.0 [1], 100000.0 [2]
N-[2-[[4-(3-Amino-1H-indazol-4-yl)benzoyl]amino]ethyl]-3,4-difluorobenzamideIC5014320.0 [1], 75290.0 [2]
N-[2-[[4-(3-Amino-1H-indazol-4-yl)benzoyl]amino]ethyl]-2-bromobenzamideIC5031.0 [1], 1040.0 [2]
N-[2-[[4-(3-Amino-1H-indazol-4-yl)benzoyl]amino]ethyl]-2-methylbenzamideIC5018.0 [1], 28790.0 [2]
N-[2-[[4-(3-Amino-1H-indazol-4-yl)benzoyl]amino]ethyl]-3-(trifluoromethyl)benzamideIC50450.0 [1], 56270.0 [2]
N-[2-[[4-(3-Amino-1H-indazol-4-yl)benzoyl]amino]ethyl]-2-methoxybenzamideIC50250.0 [1], 100000.0 [2]
4-(3-Amino-1H-indazol-4-yl)-N-[2-[(4-methoxybenzoyl)amino]ethyl]benzamideIC50100000.0 [1]
3-[2-[3-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]isoquinolin-8-yl]ethynyl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amineIC50211.0 [1], 354.0 [2]
(E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acidIC50500.0 [1], 750.0 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[[4-(trideuteriomethyl)piperazin-1-yl]methyl]benzamideIC50436.0 [1], 682.0 [2]
3-[2-[2-(Cyclopropylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC505.0 [1], 9.0 [2]
4-Methyl-3-[2-[2-(methylamino)pyrimidin-5-yl]ethynyl]-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC506.0 [1], 10.0 [2]
3-[2-[2-(Ethylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC5019.0 [1], 30.0 [2]
4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[2-(2-piperidin-1-ylpyrimidin-5-yl)ethynyl]benzamideIC50904.0 [1], 1000.0 [2]
3-[2-[2-(Cyclohexylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC5093.0 [1], 458.0 [2]
3-[2-(2-Anilinopyrimidin-5-yl)ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC50161.0 [1], 238.0 [2]
3-[2-[2-(2-Hydroxyethylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC5018.0 [1], 19.0 [2]
3-[2-[2-(Tert-butylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC5024.0 [1], 28.0 [2]
4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[2-[2-(propan-2-ylamino)pyrimidin-5-yl]ethynyl]benzamideIC50125.0 [1], 187.0 [2]
3-[2-(2-Aminopyrimidin-5-yl)ethynyl]-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideIC507.0 [1], 8.0 [2]
StaurosporineIC50121.8 [1]
ResveratrolIC5028000.0 [1]
BosutinibIC5020.0 [1]
PterostilbeneIC5010000.0 [1]
TozasertibIC5050.12 [1]
(E)-3,5,4'-TrimethoxystilbeneIC5010000.0 [1]
4-[[3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC503.98 [1]
6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-oneIC502.0 [1]
3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamideIC50267.0 [1]
Ast-487IC50580.0 [1]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC50398.11 [1]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5018.0 [1]
5-(6-Hydroxynaphthalen-2-yl)benzene-1,3-diolIC5020000.0 [1]
N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamideIC503.0 [1]
Flt-3 Inhibitor IIIC504200.0 [1]
5-[4-(4-Hydroxyphenyl)phenyl]benzene-1,3-diolIC5020000.0 [1]
3-Chloro-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5010.0 [1]
N-[5-[(2S)-2-Methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamideIC5025.12 [1]
4-Amino-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamideIC5067608.3 [1]
7-[3-(Azetidin-1-yl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
3-Fluoro-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5063.1 [1]
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC505.01 [1]
N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideIC50602.56 [1]
3-Iodo-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5010.0 [1]
3-Bromo-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC507.08 [1]
5-[(E)-3,5-Dimethoxystyryl]phenolIC5026000.0 [1]
4-(4-Methylpiperazin-1-yl)-N-[5-(2-thiophen-2-ylacetyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamideIC5064.57 [1]
4-[(4-Methyl-1-piperazinyl)methyl]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamideIC50100.0 [1]
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC503.98 [1]
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamineIC501513.56 [1]
4-[[Hydroxymethyl(methyl)amino]diazenyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC503162.28 [1]
4-(Dimethylaminodiazenyl)-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC502187.76 [1]
2-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenolIC5024000.0 [1]
4-[[3-(Dimethylamino)azetidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC5016.98 [1]
[3-(2-Imidazol-1-yl-ethoxy)-phenyl]-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC501000.0 [1]
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50398.11 [1]
1-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-3-(3-pyrrolidin-1-ylphenyl)ureaIC50724.44 [1]
6-(3,5-Dimethoxy-phenyl)-naphthalen-2-olIC5042000.0 [1]
2-(3,5-Dimethoxy-phenyl)-6-methoxy-naphthaleneIC50100000.0 [1]
(3-Imidazol-1-yl-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC503311.31 [1]
(3-Chloro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC501513.56 [1]
N-(3-Methylphenyl)-4-pyridin-3-ylpyrimidin-2-amineIC501819.7 [1]
4-[(E)-3-(Hydroxyamino)-3-oxoprop-1-enyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamideIC502700.0 [1]
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamideIC505754.4 [1]
4-Amino-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC509772.37 [1]
4-[[2-Chloroethyl(methyl)amino]diazenyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5017378.01 [1]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]piperidine-1-carboxamideIC5010000.0 [1]
4-Methyl-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]piperazine-1-carboxamideIC505011.87 [1]
1-[3-(Dimethylamino)phenyl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]ureaIC50575.44 [1]
1-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-3-(2-pyrrolidin-1-ylethyl)ureaIC508912.51 [1]
1-[4-(Dimethylamino)phenyl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]ureaIC5010000.0 [1]
1-[3-(Diethylamino)phenyl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]ureaIC501000.0 [1]
1-[4-(Diethylamino)phenyl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]ureaIC5010000.0 [1]
4-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-2,6-dimethoxy-phenolIC5023000.0 [1]
2-[3-(1,4-Diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrileIC505000.0 [1]
N-(4-Pyridin-4-yl-pyrimidin-2-yl)-benzene-1,3-diamineIC50602.56 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Bcr/Abl fusion protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/bcr-abl-fusion-protein-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Bcr/Abl fusion protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/bcr-abl-fusion-protein-inhibitors-ic50-ki.
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