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Autotaxin Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylateIC502.8 [1]
ZiritaxestatIC50100.0 [1]
ZiritaxestatKi15.0 [1]
2-[4-[(3,5-Dichlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidIC501200.0 [1], 1600.0 [2]
2-[4-[(3,5-Dichlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidKi1900.0 [1], 6500.0 [2]
8-Ethyl-5-oxo-2-[4-(9H-xanthene-9-carbonylcarbamothioyl)piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acidIC501500.0 [1], 1700.0 [2]
8-Ethyl-5-oxo-2-[4-(9H-xanthene-9-carbonylcarbamothioyl)piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acidKi2700.0 [1], 19800.0 [2]
ATX inhibitor 1IC501.23 [1], 1.3 [2], 2.18 [3], 7.9 [4], 136.0 [5]
SodiumIC50922.0 [1], 1310.0 [2]
SodiumKi824.0 [1], 1890.0 [2]
4-(4-(2-(Naphthalen-1-yl)-1,3-dioxoisoindoline-5-carbonyl)phenoxy)benzoic acidIC506800.0 [1]
4-(4-(2-(Naphthalen-1-yl)-1,3-dioxoisoindoline-5-carbonyl)phenoxy)benzoic acidKi5800.0 [1], 32300.0 [2]
6-[6-Chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acidIC504.0 [1], 22.0 [2], 300.0 [3]
3,5-Dichlorobenzyl 4-(4-(1H-1,2,3-triazol-4-yl)butanamido)piperidine-1-carboxylateIC502.0 [1], 3.1 [2], 9.0 [3]
1-Oleoyl-sn-glycerol 3-phosphateIC50442.0 [1], 499.8 [2]
1-Oleoyl-sn-glycerol 3-phosphateKi100.0 [1]
Anti-BrP-LPAIC5022.0 [1]
2,4-Dichloro-N-(3-fluorophenyl)-5-(morpholin-4-ylsulfonyl)benzamideIC5031.4 [1], 116.0 [2], 117.0 [3]
[4-[2-[[1-[(3,5-Dichlorophenyl)methoxycarbonyl]piperidin-4-yl]carbamoyl]-1,3-thiazol-4-yl]phenyl]methylphosphonic acidIC502.19 [1], 14.99 [2]
3-(3-Benzylimidazo[4,5-b]pyridin-2-yl)-N-[(4-methoxyphenyl)methyl]propanamideIC5040.0 [1], 473.0 [2], 8870.0 [3]
[(2R,3S)-3-(Hexadecanoylamino)-2-hydroxy-4-[4-[(4-methoxy-3,5-dimethylpyridin-2-yl)methoxy]phenyl]butyl]phosphonic acidKi390.0 [1], 1000.0 [2], 1300.0 [3]
3-(1,3-Dioxo-2-(4-(phenyldiazenyl)phenyl)isoindoline-5-carboxamido)benzoic acidIC5012800.0 [1]
3-(1,3-Dioxo-2-(4-(phenyldiazenyl)phenyl)isoindoline-5-carboxamido)benzoic acidKi15100.0 [1], 40300.0 [2]
2-[[2-Ethyl-6-[1-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperidin-4-yl]imidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrileIC5027.0 [1]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC501.0 [1], 14.0 [2], 38.0 [3]
(4-Tetradecylphenyl)methylphosphonic acidIC50170.0 [1]
(4-Tetradecylphenyl)methylphosphonic acidKi270.0 [1], 280.0 [2]
8-Ethyl-5-oxo-2-[4-[[4-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acidIC501500.0 [1]
8-Ethyl-5-oxo-2-[4-[[4-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acidKi13200.0 [1]
8-Ethyl-2-[4-[(3-iodophenyl)carbamothioyl]piperazin-1-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidIC501600.0 [1]
8-Ethyl-2-[4-[(3-iodophenyl)carbamothioyl]piperazin-1-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidKi7400.0 [1], 11000.0 [2]
2-[4-[(3-Chlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidIC502500.0 [1]
2-[4-[(3-Chlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidKi2600.0 [1], 47300.0 [2]
2-[4-[(2,5-Dichlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidIC501300.0 [1]
2-[4-[(2,5-Dichlorophenyl)carbamothioyl]piperazin-1-yl]-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidKi3400.0 [1], 22000.0 [2]
8-Ethyl-2-[4-[(4-iodophenyl)carbamothioyl]piperazin-1-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidIC505600.0 [1]
8-Ethyl-2-[4-[(4-iodophenyl)carbamothioyl]piperazin-1-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acidKi13200.0 [1], 34100.0 [2]
4-[[2-[(3-Ethyl-4-oxo-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-2-yl)sulfanyl]acetyl]amino]benzoic acidIC501600.0 [1]
4-[[2-[(3-Ethyl-4-oxo-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-2-yl)sulfanyl]acetyl]amino]benzoic acidKi6500.0 [1], 9300.0 [2]
3-(6-Chloranyl-2-Methyl-1-Phenyl-Indol-3-Yl)sulfanylbenzoic AcidIC505.0 [1], 81.0 [2], 300.0 [3]
3-(6-Chloro-1,2-dimethyl-1H-indol-3-ylsulfanyl)-benzoic acidIC50100.0 [1], 1000.0 [2], 1200.0 [3]
[3,5-Bis(trifluoromethyl)phenyl]methyl (1R,5S)-6-[(2H-benzotriazole-5-carbonylamino)methyl]-3-azabicyclo[3.1.0]hexane-3-carboxylateIC502.2 [1], 29.0 [2]
4-[[5-[2-[(4-Carboxyphenyl)methyl]-1,3-dioxoisoindole-5-carbonyl]-1,3-dioxoisoindol-2-yl]methyl]benzoic acidIC5012800.0 [1]
4-[[5-[2-[(4-Carboxyphenyl)methyl]-1,3-dioxoisoindole-5-carbonyl]-1,3-dioxoisoindol-2-yl]methyl]benzoic acidKi5000.0 [1]
N-(4-Bromophenyl)-2-[[5-cyano-4-(4-hydroxy-3-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]acetamideIC503800.0 [1]
N-(4-Bromophenyl)-2-[[5-cyano-4-(4-hydroxy-3-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]acetamideKi9800.0 [1]
[4-[[4-[(Z)-[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acidIC505.67 [1], 5.7 [2]
[(3S)-1-Bromo-3-hydroxy-4-octadecanoyloxybutyl]phosphonic acidIC50170.3 [1]
[(3S)-1-Bromo-3-hydroxy-4-octadecanoyloxybutyl]phosphonic acidKi40100.0 [1]
2-[4-[2-Ethyl-3-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-methylamino]imidazo[1,2-a]pyridin-6-yl]piperidin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanoneIC50246.0 [1]
N-(2-Ethyl-6-morpholin-4-ylimidazo[1,2-a]pyridin-3-yl)-4-(4-fluorophenyl)-N-methyl-1,3-thiazol-2-amineIC508.0 [1], 6800.0 [2]
3-[(6-Chloro-2-methyl-1H-indol-3-yl)sulfanyl]benzoic acidIC50290.0 [1], 747.0 [2]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-2-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]oxyacetamideIC505.0 [1], 99.0 [2]
3-(3-Benzylimidazo[4,5-b]pyridin-2-yl)-N-(cyclohexylmethyl)propanamideIC50444.0 [1], 9700.0 [2]
[3-[(4-Fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]methyl N-[(1S)-1-(4-fluorophenyl)ethyl]carbamateIC50366.0 [1], 3294.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-[(4-fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC506.0 [1], 444.0 [2]
3-(3-Benzylimidazo[4,5-b]pyridin-2-yl)-N-[(1S)-1-phenylethyl]propanamideIC5068.0 [1], 288.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-2-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]sulfanylacetamideIC502.0 [1], 19.0 [2]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[3-[[4-(trifluoromethyl)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC502.0 [1], 16.0 [2]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-c]pyridin-2-yl]propanamideIC503.0 [1], 34.0 [2]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[3-[[4-(difluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC502.0 [1], 44.0 [2]
N-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[3-[(4-methoxyphenyl)methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC503.0 [1], 215.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-c]pyridin-2-yl]propanamideIC508.0 [1], 32.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-[(4-fluorophenyl)methyl]imidazo[4,5-c]pyridin-2-yl]propanamideIC5052.0 [1], 333.0 [2]
1-[(1S)-1-(4-Chlorophenyl)ethyl]-3-[[3-[(4-fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]methyl]ureaIC5010.0 [1], 414.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-2-[3-[(4-fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]oxyacetamideIC5039.0 [1], 821.0 [2]
3-[3-[(4-Methoxyphenyl)methyl]imidazo[4,5-b]pyridin-2-yl]-N-[(1R)-1-phenylethyl]propanamideIC501060.0 [1], 8500.0 [2]
N-[(1S)-1-(4-Fluorophenyl)ethyl]-2-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]sulfinylacetamideIC50178.0 [1], 207.0 [2]
3-[3-[(4-Methoxyphenyl)methyl]imidazo[4,5-b]pyridin-2-yl]-N-[(1S)-1-phenylethyl]propanamideIC5017.0 [1], 318.0 [2]
1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[[3-[(4-fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]methyl]ureaIC5080.0 [1], 1050.0 [2]
4-[[4-[(Z)-[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]-2-methoxyphenoxy]methyl]benzoic acidIC5056.0 [1], 2500.0 [2]
(3,5-Dichlorophenyl)methyl (3R)-3-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]pyrrolidine-1-carboxylateIC5020.0 [1]
(3,5-Dichlorophenyl)methyl (3R)-3-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]pyrrolidine-1-carboxylateKi6.0 [1]
N-[(1R)-1-(4-Chlorophenyl)-2-hydroxyethyl]-3-[3-[(4-fluorophenyl)methyl]imidazo[4,5-b]pyridin-2-yl]propanamideIC505.0 [1], 26.0 [2]
5-Amino-3-[[4-[4-[(6-amino-3-hydroxy-1-sulfonaphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]-4-hydroxynaphthalene-2,7-disulfonic acidIC501260.0 [1]
5-Amino-3-[[4-[4-[(6-amino-3-hydroxy-1-sulfonaphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]-4-hydroxynaphthalene-2,7-disulfonic acidKi1460.0 [1]
(3,5-Dichlorophenyl)methyl 4-[[4-[4-(methanesulfonamido)phenyl]-1,3-thiazole-2-carbonyl]amino]piperidine-1-carboxylateIC502.99 [1], 735.0 [2]
6-[6-Methoxy-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acidIC5075.0 [1], 124.0 [2]
6-(6-Chloro-1-cyclopentyl-2-methylindol-3-yl)sulfanylpyridine-2-carboxylic acidIC502000.0 [1], 2800.0 [2]
3-(2-Methyl-1-phenylindol-3-yl)sulfanylbenzoic acidIC505000.0 [1], 30000.0 [2]
Ethyl 4-[[3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-methylamino]-2-ethylimidazo[1,2-a]pyridin-6-yl]methylamino]piperidine-1-carboxylateIC509.0 [1], 1210.0 [2]
6-[(6-Chloro-2-methyl-1H-indol-3-yl)sulfanyl]pyridine-2-carboxylic acidIC5025.0 [1], 604.0 [2]
Ethyl 4-[[3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-methylamino]-2-ethylimidazo[1,2-a]pyridine-6-carbonyl]amino]piperidine-1-carboxylateIC505.0 [1], 6555.0 [2]
6-(6-Chloro-1,2-dimethylindol-3-yl)sulfanylpyridine-2-carboxylic acidIC5031.0 [1], 4000.0 [2]
6-[2,6-Dimethyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acidIC5025.0 [1], 85.0 [2]
3-[6-Chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]oxybenzoic acidIC50204.0 [1], 726.0 [2]
3-[[6-Chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]methyl]benzoic acidIC5033.0 [1], 660.0 [2]
6-[6-Fluoro-2-methyl-1-(1-methylpyrazol-3-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acidIC50349.0 [1], 816.0 [2]
6-[[6-Chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]methyl]pyridine-2-carboxylic acidIC5089.0 [1], 339.0 [2]
6-[2-Methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acidIC501700.0 [1], 5700.0 [2]
N-(2-Ethyl-6-pyridin-3-ylimidazo[1,2-a]pyridin-3-yl)-4-(4-fluorophenyl)-N-methyl-1,3-thiazol-2-amineIC502.0 [1], 10000.0 [2]
3-(6-Chloro-1-cyclopentyl-2-methylindol-3-yl)sulfanylbenzoic acidIC504000.0 [1], 20000.0 [2]
[4-[(1-Phenylmethoxycarbonylpiperidine-4-carbonyl)amino]phenyl]methylphosphonic acidIC507.17 [1], 255.0 [2]
[2-[[1-[(3,5-Dichlorophenyl)methoxycarbonyl]piperidine-4-carbonyl]amino]-1,3-thiazol-4-yl]methylphosphonic acidIC501.75 [1], 26.5 [2]
[4-[[1-[(3-Chlorophenyl)methoxycarbonyl]piperidine-4-carbonyl]amino]phenyl]methylphosphonic acidIC501.79 [1], 39.6 [2]
[4-[[1-[[4-(Trifluoromethoxy)phenyl]methoxycarbonyl]piperidine-4-carbonyl]amino]phenyl]methylphosphonic acidIC501.97 [1], 3.12 [2]
(3,5-Dichlorophenyl)methyl 4-[[4-(hydroxycarbamoyl)phenyl]carbamoyl]piperidine-1-carboxylateIC5018.72 [1], 496.0 [2]
[4-[[1-[[2-Fluoro-4-(trifluoromethoxy)phenyl]methoxycarbonyl]piperidine-4-carbonyl]amino]phenyl]methylphosphonic acidIC501.67 [1], 2.78 [2]
[2-[[1-[(3,5-Dichlorophenyl)methoxycarbonyl]pyrrolidin-3-yl]carbamoyl]-1,3-thiazol-4-yl]methylphosphonic acidIC503.71 [1], 54.7 [2]
[4-[[1-[(2-Chlorophenyl)methoxycarbonyl]piperidine-4-carbonyl]amino]phenyl]methylphosphonic acidIC503.29 [1], 213.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Autotaxin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/autotaxin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Autotaxin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/autotaxin-inhibitors-ic50-ki.
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