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ATPase family AAA domain-containing protein 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-Methyl-8-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]amino]-1H-1,7-naphthyridin-2-oneIC5012589.25 [1], 25118.86 [2], 31622.78 [3], 50118.72 [4]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5031.62 [1], 125.89 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]-1-methylpiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50100.0 [1], 251.19 [2], 316.23 [3]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]-1-methylpiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneKi20.0 [1]
3-Methyl-5-(5-methylpyridin-3-yl)-8-[[(3R,4R)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC50251.19 [1], 316.23 [2]
8-[[(3R,4R)-3-(Cyclohexylmethoxy)piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50199.53 [1], 316.23 [2]
5-(5-Aminopyridin-3-yl)-8-[[(3R,4R)-3-(cyclohexylmethoxy)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5039.81 [1], 125.89 [2]
(3r,4r)-3-(Cyclohexylmethoxy)piperidin-4-Yl]amino}-3-Methyl-1,2-Dihydro-1,7-Naphthyridin-2-OneIC502511.89 [1], 3981.07 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-oneIC5039.81 [1], 63.1 [2], 158.49 [3]
8-[[(3R,4R,5S)-3-[(4,4-Difluorocyclohexyl)methoxy]-5-methoxypiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5050.12 [1], 2700.0 [2]
3-Methyl-8-[(1-methylpiperidin-4-yl)amino]-1H-1,7-naphthyridin-2-oneIC507943.28 [1], 12589.25 [2]
8-[[(3R,4R)-3-Methoxypiperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5010000.0 [1]
3-Methyl-8-[(Piperidin-4-Yl)amino]-1,2-Dihydro-1,7-Naphthyridin-2-OneIC5012589.25 [1], 15848.93 [2]
5-(5-Methoxypyridin-3-Yl)-3-Methyl-8-[(Piperidin-4-Yl)amino]-1,2-Dihydro-1,7-Naphthyridin-2-OneIC501258.93 [1], 3981.07 [2]
CID 91826678IC50501.19 [1], 794.33 [2]
3-Methyl-5-(5-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC501258.93 [1], 3981.07 [2]
3-Methyl-8-[[(3R,4R)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-5-pyridin-3-yl-1H-1,7-naphthyridin-2-oneIC50199.53 [1], 251.19 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-5-pyridin-3-yl-1H-1,7-naphthyridin-2-oneIC50100.0 [1], 125.89 [2]
5-(5-Methoxypyridin-3-yl)-3-methyl-8-[[(3R,4R)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC50251.19 [1], 316.23 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-5-(5-methoxypyridin-3-yl)-3-methyl-1H-1,7-naphthyridin-2-oneIC50100.0 [1], 125.89 [2]
3-Methyl-8-[[(3R,4R)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-5-pyrimidin-5-yl-1H-1,7-naphthyridin-2-oneIC50794.33 [1], 1000.0 [2]
3-Methyl-8-[[(3R,4R)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC501584.89 [1], 3981.07 [2]
8-[[(3R,4R)-3-[[(2S,6R)-2,6-Dimethyl-1,1-dioxothian-4-yl]methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5063.1 [1], 100.0 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-ethyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5050.12 [1], 79.43 [2]
1-Methyl-2-quinoloneIC50100000.0 [1]
4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic AcidIC5031622.78 [1]
3-Methyl-1,2-dihydroquinolin-2-oneIC501000000.0 [1]
CID 91827373IC50100000.0 [1]
CID 118021718IC5080000.0 [1]
4-Cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)benzenesulfonamideIC50100000.0 [1]
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamideIC50100000.0 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-(1H-pyrazol-5-yl)-1H-1,7-naphthyridin-2-oneIC5015848.93 [1]
3-Methyl-5-(2-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
3-Methyl-5-(6-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC503981.07 [1]
3-Methyl-5-(4-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC501258.93 [1]
5-(6-Methoxypyridin-3-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC505011.87 [1]
5-(5-Chloropyridin-3-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC501995.26 [1]
5-[3-Methyl-2-oxo-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-5-yl]pyridine-3-carboxamideIC501258.93 [1]
5-(4,5-Dimethylpyridin-3-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC501584.89 [1]
5-(5-Aminopyridin-3-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC50794.33 [1]
N-[5-[3-Methyl-2-oxo-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-5-yl]pyridin-3-yl]methanesulfonamideIC501258.93 [1]
[5-[3-Methyl-2-oxo-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-5-yl]pyridin-3-yl]methyl carbamateIC501584.89 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-pyrimidin-5-yl-1H-1,7-naphthyridin-2-oneIC503981.07 [1]
3-Methyl-8-(propylamino)quinoline-2(1H)-oneIC50100000.0 [1]
3-Methyl-8-(2-hydroxyethylamino)quinoline-2(1H)-oneIC50100000.0 [1]
3-Methyl-8-(3-hydroxypropylamino)quinoline-2(1H)-oneIC50100000.0 [1]
3-Methyl-8-(1H-imidazole-2-ylmethylamino)quinoline-2(1H)-oneIC50100000.0 [1]
3-Methyl-8-(2-methoxyethylamino)quinoline-2(1H)-oneIC50100000.0 [1]
3-(2-Oxo-3-methyl-1,2-dihydroquinoline-8-ylamino)propionic acidIC50100000.0 [1]
3-Methyl-8-(2-dimethylaminoethylamino)pyrido[3,4-b]pyridine-2(1H)-oneIC50501187.23 [1]
3-Methyl-8-(3-dimethylaminopropylamino)quinoline-2(1H)-oneIC5025118.86 [1]
3-Methyl-8-(3-dimethylaminopropylamino)pyrido[3,4-b]pyridine-2(1H)-oneIC5063095.73 [1]
3-Methyl-8-(piperidin-4-ylamino)-1H-quinolin-2-oneIC5019952.62 [1]
3-Methyl-8-[[(3R)-pyrrolidin-3-yl]amino]-1H-quinolin-2-oneIC5031622.78 [1]
3-Methyl-8-[[(3R)-pyrrolidin-3-yl]amino]-1H-1,7-naphthyridin-2-oneIC5079432.82 [1]
3-Methyl-8-[[(3S)-pyrrolidin-3-yl]amino]-1H-quinolin-2-oneIC5012589.25 [1]
3-Methyl-8-[[(3S)-pyrrolidin-3-yl]amino]-1H-1,7-naphthyridin-2-oneIC5015848.93 [1]
3-Methyl-8-(2-piperidin-4-ylethylamino)-1H-1,7-naphthyridin-2-oneIC50100000.0 [1]
3-Methyl-8-(2-piperidin-3-ylethylamino)-1H-1,7-naphthyridin-2-oneIC50100000.0 [1]
3-Methyl-8-(piperidin-4-ylmethylamino)-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
8-[[3-(Dimethylamino)-2,2-dimethylpropyl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC50100000.0 [1]
3-Methyl-8-[[(3R)-piperidin-3-yl]amino]-1H-1,7-naphthyridin-2-oneIC50100000.0 [1]
8-[[(1S,3S)-3-Aminocyclohexyl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
3-Methyl-8-[[(3S)-pyrrolidin-3-yl]methylamino]-1H-1,7-naphthyridin-2-oneIC5031622.78 [1]
3-Methyl-8-(piperidin-3-ylmethylamino)-1H-1,7-naphthyridin-2-oneIC5039810.72 [1]
8-[(1-Cyclopropylpiperidin-4-yl)amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC505011.87 [1]
8-[[1-(2-Methoxyethyl)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5015848.93 [1]
8-[[1-(3-Methoxypropyl)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC506309.57 [1]
3-Methyl-5-phenyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC5010000.0 [1]
5-(1-Acetyl-2,3-dihydroindol-5-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC503162.28 [1]
5-(3-Hydroxyphenyl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC502511.89 [1]
5-(1H-Indazol-4-yl)-3-methyl-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC501258.93 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-pyridin-3-yl-1H-1,7-naphthyridin-2-oneIC501258.93 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-(1H-pyrazol-4-yl)-1H-1,7-naphthyridin-2-oneIC503162.28 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-pyridin-4-yl-1H-1,7-naphthyridin-2-oneIC5019952.62 [1]
3-Methyl-8-(piperidin-4-ylamino)-5-pyridin-2-yl-1H-1,7-naphthyridin-2-oneIC5039810.72 [1]
3-Methyl-8-[[(3R,4R)-3-[2-(oxan-4-yl)ethoxy]piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC5015848.93 [1]
8-[[(3S,4S)-3-(Cyclohexylmethoxy)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
8-[[(3S,4S)-3-(Cyclohexylmethoxy)piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC503981.07 [1]
8-[[(3R,4R)-3-[(1-Acetylpiperidin-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC507943.28 [1]
8-[[(3R,4R)-3-[(4-Hydroxycyclohexyl)methoxy]piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC505011.87 [1]
3-Methyl-8-[[(3S,4S)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC5063095.73 [1]
8-[[(3S,4S)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
8-[[(3R,4R)-3-[[(3S)-1,1-Dioxothiolan-3-yl]methoxy]piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC505011.87 [1]
3-Methyl-8-[[(3R,4R)-3-propan-2-yloxypiperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC5063095.73 [1]
3-Methyl-8-[[(3R,4R)-3-propoxypiperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC5025118.86 [1]
3-Methyl-8-[[(3R,4R)-3-(2-methylpropoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-oneIC5015848.93 [1]
8-[[(3R,4R)-3-(Cyclopentylmethoxy)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC507943.28 [1]
8-[[(3R,4R)-3-(Cycloheptylmethoxy)piperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC501995.26 [1]
8-[[(1S,2R,3R,5R)-2-[2-(1,1-Dioxothian-4-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-oneIC50251.19 [1]
8-[[(1S,2R,3R,5R)-2-[2-(4,4-Difluorocyclohexyl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50100.0 [1]
8-[[(1S,2R,3R,5R)-2-[2-(1,1-Dioxothian-4-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50251.19 [1]
8-[[(3S,4R,5R)-3-Methoxy-5-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50199.53 [1]
8-[[(3R,5S)-3,5-Dimethoxypiperidin-4-yl]amino]-3-methyl-1H-1,7-naphthyridin-2-oneIC5025118.86 [1]
3-Methyl-5-(5-methylpyridin-3-yl)-8-[[(1S,2R,3R,5R)-2-[2-(oxan-4-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-1H-1,7-naphthyridin-2-oneIC50251.19 [1]
8-[[(3R,4R)-3-[(4,4-Difluorocyclohexyl)methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-oneIC5039.81 [1]
8-[[(3R,4R,5S)-3-[(1,1-Dioxothian-4-yl)methoxy]-5-methoxypiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC50125.89 [1]
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-4-(4-methylphenoxy)butanamideIC5023000.0 [1]
3-Butyl-8-[(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanylmethyl]-7-ethylpurine-2,6-dioneIC50100000.0 [1]
8-{[2-(Dimethylamino)ethyl]amino}-3-Methyl-1,2-Dihydroquinolin-2-OneIC50100000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ ATPase family AAA domain-containing protein 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/atpase-family-aaa-domain-containing-protein-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ ATPase family AAA domain-containing protein 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/atpase-family-aaa-domain-containing-protein-2-inhibitors-ic50-ki.
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