![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d9df6cb5b3ce07978c9872c6cce8fd49.svg) | 5-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 64.0 [1], 110.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_af3bfc7cec72a8e24393f52487a4366a.svg) | 2-Fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 30.0 [1], 49.0 [2], 110.0 [3] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_9ee71176e8098421aa2c24d060ce822f.svg) | 5-[(1R)-1-Hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 29.0 [1], 41.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_87939b4b74c1292e202f267b5ab06932.svg) | 4-(2-{4-[2-(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)benzonitrile | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_b48b7169cbe7cd895e1b51e4e44dfa23.svg) | 6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 18.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_f877dc3b6850cdb3fb8fd6aff7e36ae3.svg) | 4-Methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 72.0 [1], 190.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_425e78d9dddd404a9a33cb8ca28f3bba.svg) | 1,4-Bis(4-Nitrophenethyl)Piperazine | IC50 | 24.0 [1], 52.0 [2], 66.0 [3] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_97b52f660ef1926ae4e4027b2765fa29.svg) | 6-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 57.0 [1], 60.0 [2], 80.0 [3] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_fddd3bf4e628c467bfba9ac1ce965ba4.svg) | 2,2'-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole) | IC50 | 240.0 [1], 794.33 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_f81ad02967e3989af72191a48cb1433a.svg) | 6-[8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_b7504a1f9335e90ba85af6b7a63348dd.svg) | 6-[8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile | IC50 | 10.0 [1], 10.5 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_99fd61f11ffbdfe4b33a96940e731cb5.svg) | 2-Methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 89.0 [1] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_86bf250717043b121a8dd1a289a658bb.svg) | 4-(2-{4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl}ethyl)benzonitrile | IC50 | 79.0 [1] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_3f997adb3f0f9804ba4010f78e0e5b86.svg) | 5-[(3S,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 88.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_c0e2197e7c31fbeb8772765f450bff9a.svg) | 5-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 65.0 [1], 160.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_41539d3072a72412f91bad6755f491d2.svg) | 5-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]thiazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 100.0 [1], 380.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_301354afbc40cfc0a8cf612a11bda01e.svg) | 5-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 105.0 [1], 160.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_5d43d8b0c47558ff0d03aab6168045cc.svg) | 5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 50.0 [1], 226.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_8d81080aaeedc7104e9f0bed706fc81a.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 43.0 [1], 53.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_bcbae75a9874e5f1fa259c0fec59cd56.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 34.0 [1], 74.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_0c33a44a0625292b959b5ce43545ca33.svg) | 5-[(1R)-1-Hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 37.0 [1], 44.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_79ebc4b63a540d4c6819fec324fd5a1c.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 8.0 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_0f762e340b3de330c13abe30c56aedbc.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 12.0 [1], 18.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_a6b37a4dccb9bc8bce84778839ba97b2.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 4.0 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6e44bf08432ce5a4d960cf559c1a9d4b.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one | IC50 | 11.0 [1], 64.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_1d939e2239673e5db0f300e9057d3c35.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 17.0 [1], 35.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_a1e96c1a681f30f65ab37a348a7c9594.svg) | 4-Cyclopropyl-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 46.0 [1], 54.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_ce7010078c3adb1b86dcc2b631030337.svg) | 4-Ethoxy-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 29.0 [1], 40.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_469fd7e82dc5b2be149adc741008bb24.svg) | 6-[1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-(trideuteriomethoxy)pyridine-3-carbonitrile | IC50 | 13.0 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_38bb289e7453de8c149465aa2c5b17d1.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 17.0 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_83b8800f18ed820c95387d3c08bbcb76.svg) | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 5.0 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_c57b979c0580fac5d5bc68329508b343.svg) | 3-[(4-Chlorophenyl)sulfamoyl]-4-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]benzamide | IC50 | 62.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d71d69fd996848a0113747a89400184f.svg) | 3-[(4-Chlorophenyl)sulfamoyl]-4-methoxy-N-[1-(2-methyltriazol-4-yl)ethyl]benzamide | IC50 | 61.0 [1], 12589.25 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6f705d4d45fd79917a6727bf884fce22.svg) | 4-Methyl-N-[(1-methyltriazol-4-yl)methyl]-3-[[4-(1,2-oxazol-5-yl)phenyl]sulfamoyl]benzamide | IC50 | 104.0 [1], 251.19 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_f4b046080919188b6c804b0936957f19.svg) | 5-[2-[4-[2-(1-Oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 26.0 [1], 89.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_563bfef4c9237aa1ada1359b77576e90.svg) | 2-(Methylamino)-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 410.0 [1], 430.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_871b720eb4d0df2ea6660322cb7dd4c4.svg) | 2-Cyclopropyloxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 81.0 [1], 280.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6129a193d63606be8ce0a01982245192.svg) | 6-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3,4-dihydroisochromen-1-one | IC50 | 61.0 [1], 240.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_41f6ec860365838f74e978c2531e1c34.svg) | 6-[1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methylpyridine-3-carbonitrile | IC50 | 12.0 [1], 49.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_aca179036629e21a3701cfd23c84c71f.svg) | 6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile | IC50 | 27.0 [1], 32.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_b23b20bf77263f5da3275b2f5007d093.svg) | 4-Fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 38.0 [1], 110.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_aafad008e6c9f96a338cbf1d5d9d5d30.svg) | 1-[(3R,9As)-3-(4-methyl-2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 72.0 [1], 250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_23e93f95d50c901884bf07c3f0e3678a.svg) | 1-[(3S,9As)-3-(2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 104.0 [1], 590.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6d7802aa42c46ff83a98d0025320e230.svg) | 5-[(3R,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 70.0 [1], 86.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_63029c99010568d56af64788840de619.svg) | 6-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 120.0 [1], 165.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_8bbda14d82c4eba8007b19287800ab9a.svg) | 1-[(3S,9As)-3-(4-methyl-2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 83.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_50a6fdf516c2b74d9c0fc10b7d02851b.svg) | 1-[(3R,9As)-3-(2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 45.0 [1], 180.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_387640d74f09d023d1d3a6d5a658a0b1.svg) | 6-[(3R,9As)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 240.0 [1], 260.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_48cfe11217d576336850cbd7ab366f8b.svg) | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_5ff0eccd8db137f0ed4029e6bffcfeb2.svg) | 5-[(1R)-1-Methoxy-2-[2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 30.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_4712b3af795b183880fab0911a9e6328.svg) | 2-(2,4-Dimethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 60.0 [1], 490.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_0f142c7ce4e105bc5b96ef2d98b3d7e4.svg) | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 50.0 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_3bb8d099c03432d1626bce5a1489d6ce.svg) | 2-(4-Ethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 80.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_7186754a098fd162b5a410a3bb7d7d7c.svg) | 8-[(2S)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 30.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_3413907c290dfb10a55c9161162ffc71.svg) | 2-(2,4-Dimethyl-5-oxo-2H-furan-3-yl)-8-[(2S)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 100.0 [1], 380.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_917f480fa2fd2ebb8ad1dbb1178ae845.svg) | 1-[(3R,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[5-(tetrazol-1-yl)pyridin-2-yl]ethanone | IC50 | 70.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_49f3c2a77267d257ab9b646d6efd0784.svg) | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[5-(tetrazol-1-yl)pyridin-2-yl]ethanone | IC50 | 90.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d0528c24815254be0f331d7cc4793389.svg) | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 40.0 [1], 50.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_5f4b695dadf4997042e8970ea0f909cc.svg) | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 40.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_b41942268dd41b6e79bf536f45ff57f6.svg) | 1-[(3R,9As)-3-(3-isocyano-4-methoxy-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 80.0 [1], 130.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_dca63d4d83cd356e0f367bc6abbc729a.svg) | 1-[(3R,9As)-3-(2-fluoro-5-isocyano-4-methoxyphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 190.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_5c731ccdaa1683f30711c592be98da71.svg) | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methoxyphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 70.0 [1], 130.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_411cba9acf604ffa0ecfce96d8c7f1a6.svg) | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[4-methyl-2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 90.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_affcabdc3d8abfcd0b3bb01d3767a01d.svg) | 1-[(7R,9Ar)-7-(4-fluoro-3-isocyano-2-methylphenyl)-1,3,4,6,7,8,9,9a-octahydropyrazino[1,2-a]pyrazin-2-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 60.0 [1] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_413ee8000fab7b8be6b442f07ad9d65c.svg) | 1-[3-(4-Fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 30.0 [1], 80.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6175f51fd68078b7875dec98e69e4c88.svg) | (3R)-3-Methyl-6-[(3S)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 70.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_e0ef724313a127c792684b6755694d55.svg) | 6-[1-Hydroxy-2-[3-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,6-diazabicyclo[3.2.0]heptan-6-yl]ethyl]pyridine-3-carbonitrile | IC50 | 540.0 [1], 1800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_4a4d37edf148c95e9a65a27410e6c81a.svg) | 5-[(1S)-1-Hydroxy-2-[5-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 36.0 [1], 117.3 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_7859bbec374be9561f02c24668195ce9.svg) | 6-[1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 566.0 [1], 2404.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_68d9a9e9e66680a0eadf9696ff8656ab.svg) | 5-[(1S)-1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 76.0 [1], 184.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_1a250e6e45e6b8e92189c4a92cf37617.svg) | 6-[1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 53.0 [1], 91.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_8d82923c3dd4576c591db9f1179b334d.svg) | 5-[(1S)-1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 57.0 [1], 105.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6661e5301b6833c5fd817d6e6e2e3fbb.svg) | 5-[(1S)-1-Hydroxy-2-[2-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 94.0 [1], 728.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d43e3a571d3c749938703fd9b513c196.svg) | 5-[(1S)-1-Hydroxy-2-[1-[3-methyl-4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 125.0 [1], 294.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d20c8d4d92bdca3cf45773a2726b0c2a.svg) | 5-[(1S)-1-Hydroxy-2-[1-[4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 66.0 [1], 284.7 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_0e864922f40b6810b32fbbbec27048b8.svg) | 5-[(1R)-1-Hydroxy-2-[5-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 62.0 [1], 120.3 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_14d8ba0484181b6f4a51f0154ae71654.svg) | 5-[(1R)-1-Hydroxy-2-[2-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,9-diazaspiro[4.5]decan-9-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 117.0 [1], 274.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_758387373618076d60045f37f9a2c742.svg) | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,9-diazaspiro[4.5]decan-9-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 348.0 [1], 737.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_6dfb4adbaa8e316691bf45fa4311e2a9.svg) | 5-[(1R)-1-Hydroxy-2-[2-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 201.0 [1], 358.6 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_8eb34ccaf4b7e2d6e437a57086aa90c9.svg) | 6-[1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 47.0 [1], 152.5 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_822b6e38730023457953fc0756c9f076.svg) | 4-[[1-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]sulfonyl]benzonitrile | IC50 | 62.0 [1], 402.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_f692d3ede06c75dec60892bc634da434.svg) | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 11.0 [1], 91.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_9b11199f8cc10040b88567ba716c2ae8.svg) | 6-[1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 39.0 [1], 93.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_1bf1a5e6cb4efb5e555ccdf2cf16b1f3.svg) | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 40.0 [1], 82.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_4a43cb21a8be56b4d85d07da977c2e1a.svg) | 5-[(1R)-1-Hydroxy-2-[2-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 31.0 [1], 86.33 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_2e00633349384bdbd0f560821c7788ee.svg) | 5-[(1R)-1-Hydroxy-2-[7-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,7-diazaspiro[4.5]decan-2-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 108.0 [1], 241.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_09b43aa9d0950129cefed01cd042762f.svg) | 5-[(1R)-1-Hydroxy-2-[5-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 103.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_ae186522500c667f488816445051ccd9.svg) | 5-[(1R)-1-Hydroxy-2-[5-[5-(tetrazol-1-yl)pyridine-2-carbonyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 602.2 [1], 850.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_bcdd1c9712ae691869be8df2442589ec.svg) | 5-[(1R)-1-Hydroxy-2-[5-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 270.0 [1], 542.7 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_035009abbe836d22a9de6f2b88b7fe2a.svg) | 5-[(1R)-1-Hydroxy-2-[1-[3-methyl-4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 79.0 [1], 137.7 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_d739bc629959e74b589ffcdf70763e81.svg) | 5-[(1R)-1-Hydroxy-2-[1-[4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 46.0 [1], 289.7 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_91b36754eff937014d7d44e112c19b36.svg) | 5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridine-3-carbonyl)-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 319.4 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_05a0ee1aaafc300f18db4dd8d8d43c2c.svg) | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 310.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_a3e77ab896ea62fcb9d5db5a838e0e5d.svg) | 2-(5-Oxo-2H-furan-3-yl)-8-[(3-oxo-1,6,8,9-tetrahydrofuro[3,4-f]isochromen-6-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 60.0 [1], 350.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_09ad8a63f9dfd7e6419b3ccf3630565f.svg) | 3-Ethyl-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_ad07f8de93999cdf2047533e0d46064f.svg) | 3-Cyclopropyl-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_602651497ba2cae95e2c827102bcd578.svg) | 8-[2-(4-Ethyl-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_b6d1ddce5030e64b362bc9eff9e3ee09.svg) | 8-[2-(4-Cyclopropyl-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 240.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_78c79f3f7d76018657dcf3b58b89f6fd.svg) | 8-[2-(4-Chloro-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 3.0 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/atp-sensitive-inward-rectifier-potassium-channel-1_22e4f51294d758e3f069fd855302bf65.svg) | 8-[2-(4-Fluoro-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 190.0 [2] |