 | 5-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 64.0 [1], 110.0 [2] |
 | 2-Fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 30.0 [1], 49.0 [2], 110.0 [3] |
 | 5-[(1R)-1-Hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 29.0 [1], 41.0 [2] |
 | 4-(2-{4-[2-(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)benzonitrile | IC50 | 300.0 [1] |
 | 6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 18.0 [1], 140.0 [2] |
 | 4-Methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 72.0 [1], 190.0 [2] |
 | 1,4-Bis(4-Nitrophenethyl)Piperazine | IC50 | 24.0 [1], 52.0 [2], 66.0 [3] |
 | 6-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 57.0 [1], 60.0 [2], 80.0 [3] |
 | 2,2'-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole) | IC50 | 240.0 [1], 794.33 [2] |
 | 6-[8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile | IC50 | 10.0 [1] |
 | 6-[8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile | IC50 | 10.0 [1], 10.5 [2] |
 | 2-Methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 89.0 [1] |
 | 4-(2-{4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl}ethyl)benzonitrile | IC50 | 79.0 [1] |
 | 5-[(3S,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 88.0 [1], 100.0 [2] |
 | 5-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 65.0 [1], 160.0 [2] |
 | 5-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]thiazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 100.0 [1], 380.0 [2] |
 | 5-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 105.0 [1], 160.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 50.0 [1], 226.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 43.0 [1], 53.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 34.0 [1], 74.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 37.0 [1], 44.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 8.0 [1], 37.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 12.0 [1], 18.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 4.0 [1], 8.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one | IC50 | 11.0 [1], 64.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 17.0 [1], 35.0 [2] |
 | 4-Cyclopropyl-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 46.0 [1], 54.0 [2] |
 | 4-Ethoxy-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile | IC50 | 29.0 [1], 40.0 [2] |
 | 6-[1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-(trideuteriomethoxy)pyridine-3-carbonitrile | IC50 | 13.0 [1], 23.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 17.0 [1], 23.0 [2] |
 | 8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 5.0 [1], 14.0 [2] |
 | 3-[(4-Chlorophenyl)sulfamoyl]-4-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]benzamide | IC50 | 62.0 [1], 100.0 [2] |
 | 3-[(4-Chlorophenyl)sulfamoyl]-4-methoxy-N-[1-(2-methyltriazol-4-yl)ethyl]benzamide | IC50 | 61.0 [1], 12589.25 [2] |
 | 4-Methyl-N-[(1-methyltriazol-4-yl)methyl]-3-[[4-(1,2-oxazol-5-yl)phenyl]sulfamoyl]benzamide | IC50 | 104.0 [1], 251.19 [2] |
 | 5-[2-[4-[2-(1-Oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 26.0 [1], 89.0 [2] |
 | 2-(Methylamino)-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 410.0 [1], 430.0 [2] |
 | 2-Cyclopropyloxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile | IC50 | 81.0 [1], 280.0 [2] |
 | 6-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3,4-dihydroisochromen-1-one | IC50 | 61.0 [1], 240.0 [2] |
 | 6-[1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methylpyridine-3-carbonitrile | IC50 | 12.0 [1], 49.0 [2] |
 | 6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile | IC50 | 27.0 [1], 32.0 [2] |
 | 4-Fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one | IC50 | 38.0 [1], 110.0 [2] |
 | 1-[(3R,9As)-3-(4-methyl-2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 72.0 [1], 250.0 [2] |
 | 1-[(3S,9As)-3-(2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 104.0 [1], 590.0 [2] |
 | 5-[(3R,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 70.0 [1], 86.0 [2] |
 | 6-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 120.0 [1], 165.0 [2] |
 | 1-[(3S,9As)-3-(4-methyl-2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 83.0 [1], 200.0 [2] |
 | 1-[(3R,9As)-3-(2,1,3-benzoxadiazol-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 45.0 [1], 180.0 [2] |
 | 6-[(3R,9As)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 240.0 [1], 260.0 [2] |
 | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 120.0 [2] |
 | 5-[(1R)-1-Methoxy-2-[2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 30.0 [1], 200.0 [2] |
 | 2-(2,4-Dimethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 60.0 [1], 490.0 [2] |
 | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-3-one | IC50 | 50.0 [1], 170.0 [2] |
 | 2-(4-Ethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 80.0 [2] |
 | 8-[(2S)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 30.0 [1], 140.0 [2] |
 | 2-(2,4-Dimethyl-5-oxo-2H-furan-3-yl)-8-[(2S)-2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 100.0 [1], 380.0 [2] |
 | 1-[(3R,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[5-(tetrazol-1-yl)pyridin-2-yl]ethanone | IC50 | 70.0 [1], 120.0 [2] |
 | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[5-(tetrazol-1-yl)pyridin-2-yl]ethanone | IC50 | 90.0 [1], 100.0 [2] |
 | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 40.0 [1], 50.0 [2] |
 | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 40.0 [1], 100.0 [2] |
 | 1-[(3R,9As)-3-(3-isocyano-4-methoxy-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 80.0 [1], 130.0 [2] |
 | 1-[(3R,9As)-3-(2-fluoro-5-isocyano-4-methoxyphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 190.0 [1], 210.0 [2] |
 | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methoxyphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 70.0 [1], 130.0 [2] |
 | 1-[(3S,9As)-3-(4-fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[4-methyl-2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 90.0 [1], 120.0 [2] |
 | 1-[(7R,9Ar)-7-(4-fluoro-3-isocyano-2-methylphenyl)-1,3,4,6,7,8,9,9a-octahydropyrazino[1,2-a]pyrazin-2-yl]-2-[6-(tetrazol-1-yl)pyridin-3-yl]ethanone | IC50 | 60.0 [1] |
 | 1-[3-(4-Fluoro-3-isocyano-2-methylphenyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-2-[2-(tetrazol-1-yl)pyrimidin-5-yl]ethanone | IC50 | 30.0 [1], 80.0 [2] |
 | (3R)-3-Methyl-6-[(3S)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one | IC50 | 70.0 [1], 150.0 [2] |
 | 6-[1-Hydroxy-2-[3-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,6-diazabicyclo[3.2.0]heptan-6-yl]ethyl]pyridine-3-carbonitrile | IC50 | 540.0 [1], 1800.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[5-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 36.0 [1], 117.3 [2] |
 | 6-[1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 566.0 [1], 2404.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 76.0 [1], 184.0 [2] |
 | 6-[1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 53.0 [1], 91.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[1-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 57.0 [1], 105.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[2-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 94.0 [1], 728.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[1-[3-methyl-4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 125.0 [1], 294.0 [2] |
 | 5-[(1S)-1-Hydroxy-2-[1-[4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 66.0 [1], 284.7 [2] |
 | 5-[(1R)-1-Hydroxy-2-[5-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 62.0 [1], 120.3 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,9-diazaspiro[4.5]decan-9-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 117.0 [1], 274.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,9-diazaspiro[4.5]decan-9-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 348.0 [1], 737.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 201.0 [1], 358.6 [2] |
 | 6-[1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 47.0 [1], 152.5 [2] |
 | 4-[[1-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]sulfonyl]benzonitrile | IC50 | 62.0 [1], 402.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 11.0 [1], 91.0 [2] |
 | 6-[1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]pyridine-3-carbonitrile | IC50 | 39.0 [1], 93.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[1-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 40.0 [1], 82.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 31.0 [1], 86.33 [2] |
 | 5-[(1R)-1-Hydroxy-2-[7-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,7-diazaspiro[4.5]decan-2-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 108.0 [1], 241.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[5-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 103.0 [1], 200.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[5-[5-(tetrazol-1-yl)pyridine-2-carbonyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 602.2 [1], 850.0 [2] |
 | 5-[(1R)-1-Hydroxy-2-[5-[6-(tetrazol-1-yl)pyridine-3-carbonyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 270.0 [1], 542.7 [2] |
 | 5-[(1R)-1-Hydroxy-2-[1-[3-methyl-4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 79.0 [1], 137.7 [2] |
 | 5-[(1R)-1-Hydroxy-2-[1-[4-(tetrazol-1-yl)phenyl]sulfonyl-1,7-diazaspiro[4.4]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 46.0 [1], 289.7 [2] |
 | 5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridine-3-carbonyl)-2,8-diazaspiro[5.5]undecan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one | IC50 | 319.4 [1], 1000.0 [2] |
 | 8-[(2R)-2-Methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 310.0 [2] |
 | 2-(5-Oxo-2H-furan-3-yl)-8-[(3-oxo-1,6,8,9-tetrahydrofuro[3,4-f]isochromen-6-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 60.0 [1], 350.0 [2] |
 | 3-Ethyl-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 20.0 [2] |
 | 3-Cyclopropyl-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 20.0 [1], 30.0 [2] |
 | 8-[2-(4-Ethyl-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 30.0 [2] |
 | 8-[2-(4-Cyclopropyl-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 240.0 [2] |
 | 8-[2-(4-Chloro-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 3.0 [1], 10.0 [2] |
 | 8-[2-(4-Fluoro-1-oxo-3H-2-benzofuran-5-yl)-2-hydroxyethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 10.0 [1], 190.0 [2] |
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