Arachidonate 15-lipoxygenase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nordihydroguaiaretic acid	IC50	1100.0 [1]
	5-(Methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile	IC50	200.0 [1], 50000.0 [2]
	5-(Methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile	Ki	100.0 [1], 1200.0 [2]
	6,11-Dihydro[1]benzothiopyrano[4,3-b]indole	IC50	810.0 [1]
	6,11-Dihydro[1]benzothiopyrano[4,3-b]indole	Ki	3810.0 [1]
	1H-Imidazole-5-carboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester	Ki	870.0 [1], 1400.0 [2], 8100.0 [3]
	Ethyl 6-chloro-3-[(3S)-3,7-dimethyloctanoyl]-1H-indole-2-carboxylate	IC50	90.0 [1]
	Ethyl 6-chloro-3-[(3S)-3,7-dimethyloctanoyl]-1H-indole-2-carboxylate	Ki	30.0 [1], 36.0 [2]
	Baicalein	IC50	9100.0 [1]
	Baicalein	Ki	600.0 [1]
	alpha-Mangostin	IC50	3100.0 [1], 50000.0 [2]
	Indolizine	IC50	25000.0 [1]
	Indolizine	Ki	25000.0 [1]
	Puupehenone	IC50	760.0 [1], 6000.0 [2]
	12-Oxo-ETE	IC50	3000.0 [1]
	12-Oxo-ETE	Ki	36800.0 [1]
	Phenol, 2,3,5-tribromo-6-(3,5-dibromo-2-hydroxyphenoxy)-	IC50	2200.0 [1], 2500.0 [2]
	2,3,4,5-Tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol	IC50	790.0 [1], 1300.0 [2]
	Jaspaquinol	IC50	300.0 [1], 19000.0 [2]
	4-Fluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester	Ki	10.0 [1]
	N-(2-Chlorophenyl)-1H-pyrazole-3-carboxamide	IC50	618.0 [1], 645.0 [2]
	Tribromobisphenol A	IC50	5000.0 [1], 7000.0 [2]
	Phenol, 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)-	IC50	700.0 [1], 1800.0 [2]
	Jaspic acid	IC50	1400.0 [1], 4700.0 [2]
	CID 24825377	Ki	73.0 [1]
	4-[2-(3-Carboxy-4-hydroxynaphthalen-1-yl)-2-oxoacetyl]-1-hydroxynaphthalene-2-carboxylic acid	IC50	25000.0 [1], 50000.0 [2]
	4-Ethyl-6-(4-phenoxy-1H-pyrazol-3-yl)-1,3-Benzenediol	IC50	9200.0 [1]
	2-[4-[2-[[Ethyl-[(3S)-1-[1-(4-fluorophenyl)ethyl]pyrrolidin-3-yl]sulfamoyl]amino]ethyl]-5-thiophen-2-yl-1H-pyrazol-3-yl]pyrazine	Ki	1.0 [1]
	2,6-Dichloro-4-[1,2,2-tris(3,5-dichloro-4-hydroxyphenyl)ethyl]phenol	IC50	9400.0 [1], 50000.0 [2]
	Isojaspic acid	IC50	5300.0 [1], 16000.0 [2]
	3-N-(2-Chloro-4-fluorophenyl)-1-N-hexyl-5-methylpyrazole-1,3-dicarboxamide	IC50	85.0 [1], 395.0 [2]
	N-Quinolin-3-yl-1H-pyrazole-5-carboxamide	IC50	92.0 [1], 180.0 [2]
	1h-Pyrazole-3-carboxamide,n-6-quinolinyl-	IC50	837.0 [1], 970.0 [2]
	N-Quinolin-2-yl-1H-pyrazole-5-carboxamide	IC50	334.0 [1], 3740.0 [2]
	1-N-(1,3-Benzodioxol-5-yl)-3-N-(2-chloro-4-fluorophenyl)pyrazole-1,3-dicarboxamide	IC50	47.0 [1], 109.0 [2]
	N-(2-Chloro-4-fluorophenyl)-1-[3-(trifluoromethyl)phenyl]sulfonylpyrazole-3-carboxamide	IC50	1062.0 [1], 1944.0 [2]
	4-Bromo-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxamide	IC50	39.0 [1], 290.0 [2]
	4-Bromo-5-chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide	IC50	1.0 [1], 10.0 [2]
	N-(2-Chloro-4-fluorophenyl)-4-iodo-1H-pyrazole-5-carboxamide	IC50	184.0 [1], 551.0 [2]
	N-(2-Chloro-4-fluorophenyl)-5-iodo-1H-pyrazole-3-carboxamide	IC50	27.0 [1], 150.0 [2]
	N-(2-Chloro-4-fluorophenyl)-4-nitro-1H-pyrazole-5-carboxamide	IC50	616.0 [1], 5900.0 [2]
	6-Chloro-2-(5-chloro-1H-pyrazol-3-yl)-1,3-benzoxazole	IC50	4.0 [1], 131.0 [2]
	6-Chloro-2-(4,5-dichloro-1H-pyrazol-3-yl)-1,3-benzoxazole	IC50	2.0 [1], 34.0 [2]
	3-Acetyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	2310.0 [1]
	3-Acetyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	930.0 [1]
	3-Propanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	1780.0 [1]
	3-Propanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	720.0 [1]
	3-Butanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	730.0 [1]
	3-Butanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	290.0 [1]
	Ethyl 6-chloro-3-[(3R)-3,7-dimethyloctanoyl]-1H-indole-2-carboxylate	IC50	300.0 [1]
	Ethyl 6-chloro-3-[(3R)-3,7-dimethyloctanoyl]-1H-indole-2-carboxylate	Ki	120.0 [1]
	3-Dodecanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	430.0 [1]
	3-Dodecanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	170.0 [1]
	3-Decanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	200.0 [1]
	3-Decanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	80.0 [1]
	3-Octanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	270.0 [1]
	3-Octanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	100.0 [1]
	3-Hexanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	540.0 [1]
	3-Hexanoyl-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	210.0 [1]
	3-(p-Methylphenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	2080.0 [1]
	3-(p-Methylphenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	830.0 [1]
	3-(p-Chlorophenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	1190.0 [1]
	3-(p-Chlorophenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	480.0 [1]
	3-(p-Fluorophenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	770.0 [1]
	3-(p-Fluorophenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	310.0 [1]
	3-(3-Phenylpropanoyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	560.0 [1]
	3-(3-Phenylpropanoyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	220.0 [1]
	4-Chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxamide	IC50	33.0 [1], 85.0 [2]
	5-Chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide	IC50	22.0 [1], 71.0 [2]
	N-(2-Chloro-4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide	IC50	112.0 [1], 1000.0 [2]
	4,5-Dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide	IC50	14.0 [1], 32.0 [2]
	N-Quinolin-3-yl-2H-triazole-4-carboxamide	IC50	1020.0 [1], 1400.0 [2]
	N-(2-Chloro-4-fluorophenyl)-1H-1,2,3-triazole-5-carboxamide	IC50	68.0 [1], 571.0 [2]
	N-(2,4-Dichlorophenyl)-1H-1,2,3-triazole-4-carboxamide	IC50	56.0 [1], 99.0 [2]
	N-(4-Fluorophenyl)-2H-triazole-4-carboxamide	IC50	947.0 [1], 2426.0 [2]
	N-(2-Chlorophenyl)-2H-triazole-4-carboxamide	IC50	392.0 [1], 6976.0 [2]
	N-(2,5-Dichlorophenyl)-1H-1,2,3-triazole-5-carboxamide	IC50	79.0 [1], 22530.0 [2]
	N-(5-Fluoropyridin-2-yl)-2H-triazole-4-carboxamide	IC50	3110.0 [1], 3965.0 [2]
	N-(5-Fluoropyridin-2-yl)-1H-pyrazole-5-carboxamide	IC50	118.0 [1], 550.0 [2]
	N-(5-Chloropyridin-2-yl)-1H-pyrazole-5-carboxamide	IC50	26.0 [1], 43.0 [2]
	N-[4-(Trifluoromethyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	448.0 [1], 519.0 [2]
	Benzoxazole, 2-(1H-pyrazol-3-yl)-	IC50	638.0 [1], 3273.0 [2]
	6-Chloro-2-(1H-pyrazol-5-yl)-1,3-benzoxazole	IC50	13.0 [1], 20.0 [2]
	5-Chloro-2-(1H-pyrazol-5-yl)-1,3-benzoxazole	IC50	124.0 [1], 443.0 [2]
	N-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxamide	IC50	180.0 [1], 1320.0 [2]
	(1R,3R)-5-[3-[5-[(1R,3R)-6,8-Dihydroxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-5-yl]-1-hydroxy-8-methoxy-6-methylnaphthalen-2-yl]-4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol	IC50	7600.0 [1], 50000.0 [2]
	2-Amino-N-butyl-5-phenylthiophene-3-carboxamide	IC50	12400.0 [1]
	2-Amino-N-butyl-5-phenylthiophene-3-carboxamide	Ki	3300.0 [1]
	3-(Phenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	IC50	600.0 [1]
	3-(Phenylacetyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester	Ki	250.0 [1]
	4-Amino-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxamide	IC50	69.0 [1], 641.0 [2]
	3-Amino-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxamide	IC50	334.0 [1], 5980.0 [2]
	N-Pyridin-2-yl-1H-pyrazole-5-carboxamide	IC50	1207.0 [1], 3410.0 [2]
	3-N-(2-Chloro-4-fluorophenyl)-1-N-pentylpyrazole-1,3-dicarboxamide	IC50	130.0 [1], 408.0 [2]
	6-{[3-(2-Chloro-4-fluorophenylcarbamoyl)pyrazole-1-carbonyl]-amino}-hexanoic acid ethyl ester	IC50	141.0 [1], 250.0 [2]
	N-(2-Chloro-4-fluorophenyl)-1H-pyrazole-5-carboxamide	IC50	24.0 [1], 81.0 [2]
	N-[4-Fluoro-2-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	94.0 [1], 168.0 [2]
	2-(2,3-Dichlorophenyl)-5-(methylamino)-1,3-oxazole-4-carbonitrile	IC50	460.0 [1], 50000.0 [2]
	2-(3,4-Dichlorophenyl)-5-(methylamino)-1,3-oxazole-4-carbonitrile	IC50	810.0 [1], 50000.0 [2]
	5-(Methylamino)-2-naphthalen-1-yl-1,3-thiazole-4-carbonitrile	IC50	550.0 [1], 50000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Arachidonate 15-lipoxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/arachidonate-15-lipoxygenase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ Arachidonate 15-lipoxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/arachidonate-15-lipoxygenase-inhibitors-ic50-ki.
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