Arachidonate 12-lipoxygenase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nordihydroguaiaretic acid	IC50	2600.0 [1]
	CID 70701426	IC50	340.0 [1]
	CID 70701426	Ki	350.0 [1], 720.0 [2]
	N-(1,3-Benzoxazol-2-yl)-4-[(2-hydroxy-3-methoxyphenyl)methylamino]benzenesulfonamide	IC50	790.0 [1]
	N-(1,3-Benzoxazol-2-yl)-4-[(2-hydroxy-3-methoxyphenyl)methylamino]benzenesulfonamide	Ki	530.0 [1], 620.0 [2]
	Baicalein	IC50	860.0 [1]
	Baicalein	Ki	1600.0 [1]
	Phenidone	IC50	100.0 [1]
	Puupehenone	IC50	2400.0 [1], 22000.0 [2]
	N-[(8-Hydroxy-5-nitro-quinolin-7-yl)-thiophen-2-yl-methyl]-propionamide	IC50	800.0 [1], 15000.0 [2]
	N-[(5-Bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide	IC50	13000.0 [1], 25000.0 [2]
	Tribromobisphenol A	IC50	5000.0 [1], 7000.0 [2]
	Phenol, 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)-	IC50	700.0 [1], 1800.0 [2]
	Jaspic acid	IC50	7600.0 [1], 7900.0 [2]
	4-Ethyl-6-(4-phenoxy-1H-pyrazol-3-yl)-1,3-Benzenediol	IC50	12300.0 [1]
	Isojaspic acid	IC50	3100.0 [1], 31000.0 [2]
	Quercetin	IC50	440.0 [1]
	2-Bromophenol	IC50	100000.0 [1]
	3-Hydroxyflavone	IC50	100000.0 [1]
	Fisetin	IC50	950.0 [1]
	Zileuton	IC50	55000.0 [1]
	Tetrabromobisphenol A	IC50	10000.0 [1]
	4-Bromophenol	IC50	100000.0 [1]
	alpha-Mangostin	IC50	580.0 [1]
	Hexylresorcinol	IC50	10000.0 [1]
	7-Hydroxyflavone	IC50	100000.0 [1]
	2,4-Dibromophenol	IC50	100000.0 [1]
	Morusin	IC50	100000.0 [1]
	6-Hydroxyflavone	IC50	100000.0 [1]
	2,6-Dibromophenol	IC50	100000.0 [1]
	Chloroxine	IC50	1900.0 [1]
	6,7,4'-Trihydroxyisoflavone	IC50	8700.0 [1]
	3,7-Dihydroxyflavone	IC50	100000.0 [1]
	3,6-Dihydroxyflavone	IC50	100000.0 [1]
	13-Keto-9Z,11E-octadecadienoic acid	IC50	100000.0 [1]
	Hydrazinocurcumin	IC50	7300.0 [1]
	3-Bromophenol	IC50	100000.0 [1]
	5-Oxo-ETE	IC50	15000.0 [1]
	Moracin C	IC50	210.0 [1]
	N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide	IC50	1000.0 [1]
	15-Oxo-ETE	IC50	1000.0 [1]
	3,5-Dihydroxyflavone	IC50	100000.0 [1]
	12-Oxo-ETE	IC50	8000.0 [1]
	Phenol, 2,3,5-tribromo-6-(3,5-dibromo-2-hydroxyphenoxy)-	IC50	6200.0 [1]
	2,3,4,5-Tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol	IC50	410.0 [1]
	4-{[5-(1-Naphthyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-butynyl 2-thiophenecarboxylate	IC50	100000.0 [1]
	Dysidenin	Ki	9000.0 [1]
	Spongiadioxin A	IC50	50000.0 [1]
	Jaspaquinol	IC50	50000.0 [1]
	(12E,25E,28E)-5,16,21,32-Tetrabromo-4,20-dihydroxy-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.214,17.13,7.119,23]octatriaconta-1(32),3,5,7(38),14,16,19,21,23(35),28,30,33,36-tridecaene-11,26-dione	IC50	2300.0 [1]
	N-(3-(2-Methoxybenzamido)phenyl)thiophene-2-carboxamide	IC50	100000.0 [1]
	Sodium;[(1S)-8-hydroxy-1-methyl-12,17-dioxo-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2,4,6,8,10,13(20),15-heptaen-5-yl] sulfate	IC50	200000.0 [1]
	N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]propanamide	IC50	150000.0 [1]
	N-[(5-Chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide	IC50	25000.0 [1]
	Texasin	IC50	100000.0 [1]
	4-[(2-Hydroxy-3-methoxybenzyl)amino]-N-1,3-thiazol-2-ylbenzenesulfonamide	IC50	5100.0 [1]
	Pyridine-2,6-dicarboxylic acid bis-(phenethyl-amide)	IC50	200000.0 [1]
	N-(3-(2-Methylbenzamido)phenyl)thiophene-2-carboxamide	IC50	100000.0 [1]
	N-Benzyl-3-((2,3-dihydro-1H-inden-5-yloxy)methyl)benzamide	IC50	500000.0 [1]
	N-[(5-Chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]acetamide	IC50	3000.0 [1]
	N-[(8-Hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide	IC50	3400.0 [1]
	CID 44142338	IC50	75000.0 [1]
	N-[(5-Chloro-8-methoxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide	IC50	75000.0 [1]
	N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)ethyl]propanamide	IC50	50000.0 [1]
	N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]propanamide	IC50	1200.0 [1]
	N-[(5-Chloro-8-hydroxyquinolin-7-yl)-cyclopropylmethyl]propanamide	IC50	1600.0 [1]
	N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)ethyl]acetamide	IC50	150000.0 [1]
	N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]acetamide	IC50	2600.0 [1]
	N-[(5-Chloro-8-hydroxy-7-quinolinyl)-cyclopropylmethyl]acetamide	IC50	3000.0 [1]
	N-[(2,5-Dichloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]acetamide	IC50	75000.0 [1]
	N-[1-(5-Fluoro-8-hydroxyquinolin-7-yl)ethyl]acetamide	IC50	75000.0 [1]
	N-[(5-Fluoro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]acetamide	IC50	5000.0 [1]
	N-[(5-Fluoro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide	IC50	2000.0 [1]
	4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl benzo[b]thiophene-2-carboxylate	IC50	100000.0 [1]
	N-[(5-Bromo-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide	IC50	2000.0 [1]
	4-Bromobenzyl alcohol	IC50	100000.0 [1]
	Ethyl 1-(3-(3,5-dimethylphenylamino)-3-oxopropyl)piperidine-4-carboxylate	IC50	100000.0 [1]
	4-Methyl-2-[5-(2-methylphenyl)-1H-pyrazol-3-yl]phenol	IC50	50000.0 [1]
	Chloropuupehenone	IC50	2400.0 [1]
	2,4-Dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol	IC50	12000.0 [1]
	[1,1'-Biphenyl]-2,4-diol	IC50	10000.0 [1]
	3-((N-(Aminocarbonyl)-N-hydroxyamino)methyl)-6-phenoxychromene	IC50	640.0 [1]
	N-[(5-Chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]acetamide	IC50	1000.0 [1]
	4-[2-(3-Carboxy-4-hydroxynaphthalen-1-yl)-2-oxoacetyl]-1-hydroxynaphthalene-2-carboxylic acid	IC50	150.0 [1]
	Spongiadioxin C	IC50	30000.0 [1]
	N-[2-[2-(1-Benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide	IC50	3000.0 [1]
	6,7,4'-Trihydroxyisoflavanone	IC50	3800.0 [1]
	6,7,4'-Trihydroxyisoflavan	IC50	17000.0 [1]
	Neodysidenin	IC50	100000.0 [1]
	6-Phenyl-[1,3]dioxolo[4,5-g]chromen-8-one	IC50	100000.0 [1]
	Dimethylnordihydroguarierate acid	IC50	3100.0 [1]
	4-[(2S,3R)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol	IC50	42000.0 [1]
	(4As,6aS,12bS)-10-methoxy-4,4,6a,12b-tetramethyl-1,2,3,4a,5,6-hexahydrobenzo[a]xanthen-9-ol	IC50	780.0 [1]
	4H-1-Benzopyran-4-one, 2-(1,1-dimethylethyl)-6-hydroxy-	IC50	100000.0 [1]
	3,4,6-Tribromo-2-(2,4-dibromophenoxy)phenol	IC50	6000.0 [1]
	(+)-(5S,8S,10S)-20-Methoxypuupehenol	IC50	280.0 [1]
	2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylthio)-N-phenethylacetamide	IC50	100000.0 [1]
	4-[(E)-2-[3-(4-Hydroxy-3-methoxyphenyl)-1H-pyrazol-5-yl]ethenyl]-2-methoxyphenol	IC50	7700.0 [1]
	2,3-Dihydro-6,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one	IC50	1600.0 [1]
	1-{[6-(4-Fluorophenoxy)-2h-chromen-3-yl]methyl}-1-hydroxy-3-methylurea	IC50	410.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Arachidonate 12-lipoxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 31 Mar. 2025, https://www.aatbio.com/data-sets/arachidonate-12-lipoxygenase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 31). Quest Database™ Arachidonate 12-lipoxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/arachidonate-12-lipoxygenase-inhibitors-ic50-ki.
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