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Appetite-regulating hormone Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Ulimorelin hydrochlorideKi16.0 [1]
(6S,12R,16E)-12-Benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trioneKi86.0 [1]
(6S,9R,12R)-12-Benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi6.4 [1]
(6S,9R,12R)-6-[(2S)-Butan-2-yl]-12-[(4-chlorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi0.35 [1]
(6S,9R,12R)-6-Cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trioneKi2.6 [1]
(3R,6S,9R,12R)-12-[(4-Fluorophenyl)methyl]-3,8,9-trimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi34.0 [1]
(3R,6S,9R,12R)-6-Cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trioneKi61.0 [1]
(6S,9R,12R)-6-Cyclopropyl-8,9-dimethyl-12-[[4-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi7.0 [1]
(3R,6S,9R,12R)-12-[(4-Chlorophenyl)methyl]-6-cyclopropyl-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi15.0 [1]
(3R,6S,9R,12R)-12-[(4-Fluorophenyl)methyl]-3,8,9-trimethyl-6-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi104.0 [1]
(3R,6S,9R,12R)-12-Benzyl-6-cyclopropyl-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi34.0 [1]
(6S,9R,12R)-6-Cyclopropyl-8,9-dimethyl-12-[(4-methylphenyl)methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi5.0 [1]
(3R,6S,9R,12R)-6-Cyclohexyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi0.38 [1]
(7R,10R,13S,16R)-13-Cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-24-oxa-5,8,11,14-tetrazatricyclo[14.6.2.019,23]tetracosa-1(23),19,21-triene-6,9,12-trioneKi0.9 [1]
(7R,10R,13S,16S)-13-Cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-24-oxa-5,8,11,14-tetrazatricyclo[14.6.2.019,23]tetracosa-1(23),19,21-triene-6,9,12-trioneKi19.0 [1]
(6S,9R,12R)-6-Cyclopropyl-20-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trioneKi58.0 [1]
(2S)-2-[2-[2-[(E)-3-Acetamidoprop-1-enyl]phenoxy]ethylamino]-N-[2-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-N-methylpentanamideKi10000.0 [1]
(6S,12R)-12-Benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi68.0 [1]
(6R,12R)-12-Benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi1200.0 [1]
(6S,12S)-12-Benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi380.0 [1]
(6S,12R)-12-Benzyl-6-(hydroxymethyl)-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi10000.0 [1]
(6S,12R)-6-(4-Aminobutyl)-12-benzyl-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi1100.0 [1]
3-[(6S,12R)-12-Benzyl-8-methyl-7,10,13-trioxo-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-6-yl]propanoic acidKi10000.0 [1]
(6S,12R)-6,12-Dibenzyl-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi670.0 [1]
(6S,12R)-12-Butyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi400.0 [1]
(6S,12R)-12-[(4-Hydroxyphenyl)methyl]-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi120.0 [1]
(6S,12R)-12-(Hydroxymethyl)-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi10000.0 [1]
3-[(6S,12R)-8-Methyl-7,10,13-trioxo-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]propanoic acidKi10000.0 [1]
(6S,12R)-12-(3-Aminopropyl)-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi10000.0 [1]
(6S,9R,12R)-12-Benzyl-8,9-dimethyl-6-(2-methylpropyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi25.0 [1]
(6S,9R,12R)-12-Benzyl-6-cyclopropyl-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi4.4 [1]
(6S,9R,12R)-12-Benzyl-8,9-dimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi16.0 [1]
(6S,9S,12R)-12-Benzyl-8,9-dimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi580.0 [1]
(6S,9R,12R)-12-Benzyl-9-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi500.0 [1]
(3R,6S,9R,12R)-12-Benzyl-6-[(2S)-butan-2-yl]-9-ethyl-3-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi35.0 [1]
(3R,6S,9R,12R)-12-Benzyl-6-[(2S)-butan-2-yl]-3-methyl-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi380.0 [1]
(6S,9R,12R)-6-[(2S)-Butan-2-yl]-8,9-dimethyl-12-(2-phenylethyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi43.0 [1]
(3R,6S,9R,12R)-6-[(2S)-Butan-2-yl]-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi32.0 [1]
(6S,9R,12R)-6-Cyclopropyl-12-[(2-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi6.2 [1]
(6S,9R,12R)-6-Cyclopropyl-12-[(3-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi21.0 [1]
(6S,9R,12R)-6-Cyclopropyl-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi7.3 [1]
(3R,6R,9S)-3-Benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacycloheptadecane-2,5,8-trioneKi10000.0 [1]
(3R,6R,9S)-3-Benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacyclooctadecane-2,5,8-trioneKi1500.0 [1]
(3R,6R,9S,15E)-3-Benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacyclooctadec-15-ene-2,5,8-trioneKi160.0 [1]
(6R,9R,12S)-6-Benzyl-12-[(2S)-butan-2-yl]-9,10-dimethyl-4,7,10,13-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-5,8,11-trioneKi400.0 [1]
(6S,9R,12R)-12-Benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-7,10,13-trioneKi210.0 [1]
(7R,10R,13S)-7-Benzyl-13-[(2S)-butan-2-yl]-10,11-dimethyl-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trioneKi81.0 [1]
(6S,9R,12R)-12-Benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-5,8,11,14-tetrazabicyclo[17.4.0]tricosa-1(23),19,21-triene-7,10,13-trioneKi78.0 [1]
(6S,9R,12R)-6-Cyclopropyl-12-[(4-fluorophenyl)methyl]-4,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi9.0 [1]
(3S,6S,9R,12R)-6-Cyclopropyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi56.0 [1]
(6S,9R,12R)-6-Cyclopropyl-12-[(4-fluorophenyl)methyl]-3,3,8,9-tetramethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi12.0 [1]
(3R,6S,9R,12R)-6-Cyclopropyl-12-[(4-fluoro-3-methylphenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trioneKi75.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Appetite-regulating hormone Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/appetite-regulating-hormone-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Appetite-regulating hormone Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/appetite-regulating-hormone-inhibitors-ic50-ki.
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