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Apoptosis regulator Bcl-2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Abt-737IC501.0 [1], 6.1 [2], 7.0 [3], 20.0 [4]
Abt-737Ki1.0 [1]
GossypolIC50260.0 [1], 500.0 [2], 600.0 [3], 2110.0 [4]
GossypolKi420.0 [1], 440.0 [2], 450.0 [3], 511.0 [4]
VenetoclaxIC507.39 [1], 7.4 [2]
VenetoclaxKi0.01 [1], 0.04 [2], 1.0 [3]
NavitoclaxIC5010.3 [1], 15.0 [2]
NavitoclaxKi0.04 [1], 1.0 [2]
8-Oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC50285.0 [1], 715.0 [2]
8-Oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi310.0 [1], 319.0 [2]
(2S)-N-(4-Methylphenyl)sulfonyl-2-[(5Z)-4-oxo-5-[(4-phenylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanamideKi500.0 [1], 620.0 [2], 660.0 [3], 760.0 [4], 940.0 [5]
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamideIC50200.0 [1], 700.0 [2]
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamideKi290.0 [1], 300.0 [2]
2,3,4-Trihydroxy-5-isopropyl-N-phenyl-benzamideIC507000.0 [1], 53100.0 [2]
2,3,4-Trihydroxy-5-isopropyl-N-phenyl-benzamideKi24100.0 [1], 31900.0 [2]
Antimycin A3IC502000.0 [1]
Antimycin A3Ki831.76 [1], 124000.0 [2]
4-(4-Fluorophenyl)-N-[3-nitro-4-(2-phenylsulfanylethylamino)phenyl]sulfonylbenzamideIC5093.0 [1], 6300.0 [2]
4-(4-Fluorophenyl)-N-[3-nitro-4-(2-phenylsulfanylethylamino)phenyl]sulfonylbenzamideKi433.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(4,4-dimethylpiperidin-1-yl)benzamideKi62.0 [1], 67.0 [2]
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenolIC509000.0 [1]
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenolKi169000.0 [1], 254000.0 [2]
5-Benzyl-2-(5-benzyl-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl)-3-methylnaphthalene-1,4,6,7-tetroneIC5031.0 [1], 290.0 [2]
5-Benzyl-2-(5-benzyl-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl)-3-methylnaphthalene-1,4,6,7-tetroneKi190.0 [1]
(3,4-Dihydroisoquinolin-2(1H)-yl)(2,3,4-trihydroxy-5-isopropylphenyl)methanoneIC5038200.0 [1]
(3,4-Dihydroisoquinolin-2(1H)-yl)(2,3,4-trihydroxy-5-isopropylphenyl)methanoneKi3100.0 [1]
N-Phenyl-2,3,4-trihydroxy-5-benzyl-benzamideIC505000.0 [1], 7200.0 [2]
N-Phenyl-2,3,4-trihydroxy-5-benzyl-benzamideKi8300.0 [1]
N-[4-(Benzenesulfonyl)phenyl]-5-benzyl-2,3,4-trihydroxybenzamideIC501600.0 [1], 4000.0 [2]
N-[4-(Benzenesulfonyl)phenyl]-5-benzyl-2,3,4-trihydroxybenzamideKi930.0 [1]
(-)-EpicatechinKi100000.0 [1]
(-)-Epigallocatechin gallateKi234.42 [1], 335.0 [2]
EpigallocatechinKi100000.0 [1]
(-)-Epicatechin gallateKi229.09 [1], 400.0 [2]
(2Z)-2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indoleIC501110.0 [1]
L-EpicatechinKi100000.0 [1]
ApogossypoloneIC50370.0 [1]
ApogossypoloneKi250.0 [1]
ApogossypolIC5080000.0 [1]
ApogossypolKi2800.0 [1]
2,3,5-Trihydroxy-7-methyl-N-(2-phenylpropyl)-6-[1,6,7-trihydroxy-3-methyl-5-(2-phenylpropylcarbamoyl)naphthalen-2-yl]naphthalene-1-carboxamideIC50320.0 [1], 660.0 [2]
Nvp-cgm097IC5050000.0 [1]
CID 59447577Ki74.0 [1], 80.0 [2]
AnthragallolKi583.0 [1], 1325.0 [2]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoic acidKi14200.0 [1]
Isopropyl-3-(4-isopropylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC50739.0 [1]
Isopropyl-3-(4-isopropylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi252.0 [1]
5-(4-Chlorophenyl)-4-[3-[4-[4-[[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-1,2-dimethylpyrrole-3-carboxylic acidIC501.3 [1]
5-(4-Chlorophenyl)-4-[3-[4-[4-[[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-1,2-dimethylpyrrole-3-carboxylic acidKi1.0 [1]
3,4,5-Trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-6-oneKi690.0 [1], 691.83 [2]
3-(4-Aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC50302.0 [1], 331.0 [2]
4-Benzamido-N-[3-nitro-4-(2-phenylsulfanylethylamino)phenyl]sulfonylbenzamideKi1670.0 [1], 1700.0 [2]
5-(4-Chlorophenyl)-1-ethyl-4-[3-[4-[4-[[4-[[(2R)-4-(4-hydroxypiperidin-1-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-2-methylpyrrole-3-carboxylic acidIC505.4 [1]
5-(4-Chlorophenyl)-1-ethyl-4-[3-[4-[4-[[4-[[(2R)-4-(4-hydroxypiperidin-1-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-2-methylpyrrole-3-carboxylic acidKi1.2 [1]
N-(2-Phenylethyl)-2-[2,3,4-trihydroxy-5-[methyl(3-phenylpropyl)sulfamoyl]benzoyl]-3,4-dihydro-1H-isoquinoline-7-sulfonamideIC50330.0 [1]
N-(2-Phenylethyl)-2-[2,3,4-trihydroxy-5-[methyl(3-phenylpropyl)sulfamoyl]benzoyl]-3,4-dihydro-1H-isoquinoline-7-sulfonamideKi110.0 [1]
4-[4-[[2-(4-Chlorophenyl)-6-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5010.0 [1], 45.0 [2]
4-[4-[[2-(4-Chlorophenyl)-5-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5010.0 [1], 187.0 [2]
4-[4-[[2-(4-Chlorophenyl)-6-[2-(dimethylamino)ethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC504.0 [1], 10.0 [2]
4-[4-[[2-(4-Chlorophenyl)-5-[2-(dimethylamino)ethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5010.0 [1], 22.0 [2]
2-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylpyrimidine-5-carboxamideIC5018.0 [1], 340.0 [2]
4-[4-[(R)-[2-(4-Chlorophenyl)phenyl]sulfinyl]piperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5019.0 [1], 434.0 [2]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]-4-cyanopiperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5010.0 [1], 545.0 [2]
1-(4-Phenoxyphenyl)-4-[(4-propan-2-yloxybenzoyl)amino]-5-(4-propan-2-yloxyphenyl)pyrazole-3-carboxylic acidIC505000.0 [1]
1-(4-Phenoxyphenyl)-4-[(4-propan-2-yloxybenzoyl)amino]-5-(4-propan-2-yloxyphenyl)pyrazole-3-carboxylic acidKi140.0 [1]
(5Z)-2,9-Dimethoxy-5,6-dioxido-11,12-dihydrobenzo[c][1,2]benzodiazocine-5,6-diiumIC504000.0 [1], 10400.0 [2]
N-[2-(4-Ethylphenyl)ethyl]-6-[5-[2-(4-ethylphenyl)ethylcarbamoyl]-3-methyl-1,4,6,7-tetraoxonaphthalen-2-yl]-2,3,5,8-tetrahydroxy-7-methylnaphthalene-1-carboxamideIC50210.0 [1]
N-[2-(4-Ethylphenyl)ethyl]-6-[5-[2-(4-ethylphenyl)ethylcarbamoyl]-3-methyl-1,4,6,7-tetraoxonaphthalen-2-yl]-2,3,5,8-tetrahydroxy-7-methylnaphthalene-1-carboxamideKi140.0 [1]
3-Methyl-5-(2-phenylacetyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-phenylacetyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneIC50220.0 [1]
3-Methyl-5-(2-phenylacetyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-phenylacetyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneKi150.0 [1]
2,3,5,8-Tetrahydroxy-7-methyl-6-[3-methyl-1,4,6,7-tetraoxo-5-(2-phenylpropylcarbamoyl)naphthalen-2-yl]-N-(2-phenylpropyl)naphthalene-1-carboxamideIC50230.0 [1]
2,3,5,8-Tetrahydroxy-7-methyl-6-[3-methyl-1,4,6,7-tetraoxo-5-(2-phenylpropylcarbamoyl)naphthalen-2-yl]-N-(2-phenylpropyl)naphthalene-1-carboxamideKi150.0 [1]
5-(Cyclopentylmethyl)-2-[5-(cyclopentylmethyl)-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneIC502270.0 [1]
5-(Cyclopentylmethyl)-2-[5-(cyclopentylmethyl)-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneKi1530.0 [1]
5-(2-Cyclohexylethyl)-2-[5-(2-cyclohexylethyl)-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneIC506730.0 [1]
5-(2-Cyclohexylethyl)-2-[5-(2-cyclohexylethyl)-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneKi4470.0 [1]
3-Methyl-5-(2-phenylethyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-phenylethyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneIC502570.0 [1]
3-Methyl-5-(2-phenylethyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-phenylethyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneKi1730.0 [1]
5-[(4-Chlorophenyl)methyl]-2-[5-[(4-chlorophenyl)methyl]-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneIC50340.0 [1]
5-[(4-Chlorophenyl)methyl]-2-[5-[(4-chlorophenyl)methyl]-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl]-3-methylnaphthalene-1,4,6,7-tetroneKi230.0 [1]
3-Methyl-5-(2-methylpropyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-methylpropyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneIC50250.0 [1]
3-Methyl-5-(2-methylpropyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(2-methylpropyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneKi170.0 [1]
3-Methyl-5-[2-(4-methylphenyl)ethyl]-2-[1,4,6,7-tetrahydroxy-3-methyl-5-[2-(4-methylphenyl)ethyl]naphthalen-2-yl]naphthalene-1,4,6,7-tetroneIC503120.0 [1]
3-Methyl-5-[2-(4-methylphenyl)ethyl]-2-[1,4,6,7-tetrahydroxy-3-methyl-5-[2-(4-methylphenyl)ethyl]naphthalen-2-yl]naphthalene-1,4,6,7-tetroneKi2080.0 [1]
3-Methyl-5-(3-phenylpropyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(3-phenylpropyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneIC502170.0 [1]
3-Methyl-5-(3-phenylpropyl)-2-[1,4,6,7-tetrahydroxy-3-methyl-5-(3-phenylpropyl)naphthalen-2-yl]naphthalene-1,4,6,7-tetroneKi1450.0 [1]
N-[4-(2-Tert-butylphenyl)sulfonylphenyl]-2,3,4-trimethoxy-5-[(2-propan-2-ylphenyl)methyl]benzamideIC50100000.0 [1]
N-[4-(2-Tert-butylphenyl)sulfonylphenyl]-2,3,4-trimethoxy-5-[(2-propan-2-ylphenyl)methyl]benzamideKi25000.0 [1]
N-(2-Phenylethyl)-2-(2,3,4-trihydroxy-5-propan-2-ylbenzoyl)-3,4-dihydro-1H-isoquinoline-7-sulfonamideIC506600.0 [1]
N-(2-Phenylethyl)-2-(2,3,4-trihydroxy-5-propan-2-ylbenzoyl)-3,4-dihydro-1H-isoquinoline-7-sulfonamideKi590.0 [1]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-4-chloro-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC5030.0 [1], 100.0 [2]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideIC5011.0 [1], 14.0 [2]
N,N-Dibutyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-5-methylpyrazole-3-carboxamideIC50230.0 [1], 2010.0 [2]
N,N-Dibutyl-4-chloro-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methylpyrazole-3-carboxamideIC50100.0 [1], 780.0 [2]
4-Bromo-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC5040.0 [1], 210.0 [2]
4-Chloro-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC5050.0 [1], 480.0 [2]
4-Bromo-N,N-diethyl-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methylpyrazole-3-carboxamideIC503670.0 [1], 17300.0 [2]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC5020.0 [1], 160.0 [2]
1-[4-Amino-2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC5090.0 [1], 700.0 [2]
1-[4-Benzamido-2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC50810.0 [1], 5660.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Apoptosis regulator Bcl-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/apoptosis-regulator-bcl-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Apoptosis regulator Bcl-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/apoptosis-regulator-bcl-2-inhibitors-ic50-ki.
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