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Apelin Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]pentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi0.04 [1]
5-[12-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi430.0 [1]
5-[6-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]hexylsulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi310.0 [1]
5-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi400.0 [1]
5-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzenesulfonate;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi89.0 [1]
5-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-benzylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi270.0 [1]
5-[12-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonateKi690.0 [1]
(2S)-6-Acetamido-N-[(2S)-3-(1-benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]-2-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]hexanamide;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi100000.0 [1]
[9-[4-[12-[[(5S)-6-[[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(1,1-dimethylpiperidin-1-ium-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi3000.0 [1]
[9-[4-[12-[[(5S)-6-[[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi1500.0 [1]
[9-[4-[12-[[(5S)-5-[[2-(2-Amino-1,3-thiazol-4-yl)acetyl]amino]-6-[[(2S)-3-(1-benzylimidazol-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi9000.0 [1]
[9-[4-[[(5S)-6-[[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi960.0 [1]
[9-[4-[4-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]amino]butylsulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi100000.0 [1]
[9-[4-[[(5S)-6-[[(2S)-1-[[(2S)-1-Amino-1-oxopropan-2-yl]amino]-3-(1-benzyl-3-methylimidazol-1-ium-4-yl)-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi970.0 [1]
[6-(Diethylamino)-9-[4-[[(5S)-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-[[(2S)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]xanthen-3-ylidene]-diethylazaniumKi450.0 [1]
[9-[4-[[(5S)-5-Acetamido-6-[[(2S)-3-(1-benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi1200.0 [1]
[9-[4-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-(oxan-4-ylamino)-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi980.0 [1]
[9-[4-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)methylamino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi180.0 [1]
[9-[4-[[(5S)-5-[[2-(2-Amino-1,3-thiazol-4-yl)acetyl]amino]-6-[[(2S)-3-(1-benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1-methylpiperidin-4-yl)amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]sulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi850.0 [1]
[9-[4-[12-[[(5S)-6-[[(2S)-3-(1-Benzyl-3-methylimidazol-1-ium-4-yl)-1-[(1,1-dimethylpiperidin-1-ium-4-yl)amino]-1-oxopropan-2-yl]amino]-5-[[2-(2-imino-3-methyl-1,3-thiazol-4-yl)acetyl]amino]-6-oxohexyl]carbamoylamino]dodecylsulfamoyl]-2-sulfophenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazaniumKi1400.0 [1]
Items per page: 1 - 10 of 20
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References

This online tool may be cited as follows

MLA

"Quest Database™ Apelin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/apelin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Apelin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/apelin-inhibitors-ic50-ki.
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