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Angiotensin II type 2 (AT-2) receptor Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
Angiotensin IIIC500.08 [1], 2.5 [2]
LosartanIC5019.0 [1], 10000.0 [2]
SaralasinIC500.53 [1], 1.32 [2]
SaralasinKi0.15 [1], 0.38 [2]
Butyl N-[3-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateIC502.0 [1]
Butyl N-[3-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateKi2.8 [1]
Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-propylphenyl]sulfonylcarbamateIC504.2 [1], 6.1 [2]
Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-propylphenyl]sulfonylcarbamateKi1.5 [1]
PD 123319 ditrifluoroacetateIC506.9 [1], 8.3 [2], 34.0 [3]
Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-(2-methylpropyl)phenyl]sulfonylcarbamateIC500.7 [1]
Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-(2-methylpropyl)phenyl]sulfonylcarbamateKi2.1 [1]
(3S)-3-Amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-3-(4-aminophenyl)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidKi0.7 [1], 0.9 [2], 1.4 [3], 2.1 [4]
OlodanriganIC500.58 [1], 0.6 [2]
OlodanriganKi39.5 [1]
Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-[(3-methoxyphenyl)methyl]phenyl]sulfonylcarbamateIC50101.0 [1]
Butyl N-[2-[4-(imidazol-1-ylmethyl)phenyl]-4-(2-methylpropyl)phenyl]sulfonylcarbamateKi0.6 [1], 0.7 [2]
Butyl N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateKi17.8 [1], 270.0 [2]
(Sar1,Ile8)-Angiotensin IIKi0.14 [1]
N-[4-Oxo-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]-N-pentylbenzamideIC500.7 [1], 7.0 [2]
Butyl N-[2-[3-(imidazol-1-ylmethyl)phenyl]-4-(2-methylpropyl)phenyl]sulfonylcarbamateKi12.3 [1]
Tert-butyl N-[2-[4-[[1-[2-bromo-5-(pentanoylamino)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC500.12 [1], 3.4 [2]
(3S)-3-Amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-4-[2-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-[(4-hydroxyphenyl)methyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-7-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidKi3.0 [1]
(3S)-3-Amino-4-[[(2S)-1-[[(2S)-4-[2-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-[(4-hydroxyphenyl)methyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-7-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
2-Propyl-5-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acidIC5060.0 [1]
Tert-butyl N-[2-[4-[[3-butyl-1-[2-chloro-5-[(2-ethoxyacetyl)amino]phenyl]-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC501.2 [1], 2.5 [2]
Tert-butyl N-[2-[4-[[3-butyl-5-oxo-1-[5-(pentanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC500.88 [1], 3.8 [2]
Tert-butyl N-[2-[4-[[1-(5-acetamido-2-chlorophenyl)-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]-4-propylphenyl]sulfonylcarbamateIC500.82 [1], 12.0 [2]
N-[2-[4-[[3-Butyl-5-oxo-1-[5-(propanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2-chlorobenzamideIC501.3 [1], 3.5 [2]
(2S,3S)-2-[[3-(Imidazol-1-ylmethyl)benzoyl]amino]-3-methylpentanoic acid;2,2,2-trifluoroacetic acidKi47000.0 [1], 110000.0 [2]
(2-Benzoylphenyl)methyl 5-ethyl-3-[[2-fluoro-4-[2-(3-methylbutoxycarbonylsulfamoyl)phenyl]phenyl]methyl]-2-propylimidazole-4-carboxylateIC500.69 [1], 0.7 [2]
N-[2-[4-[[1-(5-Acetamido-2-chlorophenyl)-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]-4-propylphenyl]sulfonyl-2-chlorobenzamideIC500.48 [1], 17.0 [2]
1,4-Di(diphenylcarbamoyl)-(2S)-hexahydro-2-pyrazinecarboxylic acidIC500.89 [1], 1.5 [2]
Losartan potassiumIC5010000.0 [1]
CandesartanKi10000.0 [1]
TelmisartanIC500.33 [1]
MiconazoleKi7779.0 [1]
(Sar1)-Angiotensin IIKi0.18 [1]
4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acidIC50200.0 [1]
2-Ethyl-5,7-dimethyl-3-((4-(2-(2H-tetrazol-5-yl)phenyl)phenyl)methyl)imidazo(4,5-b)pyridineIC500.2 [1]
Potassium;2-butyl-5-methylsulfanyl-3-[[4-[2-(propylcarbamoylsulfamoyl)phenyl]phenyl]methyl]imidazole-4-carboxylateIC50920.0 [1]
PratosartanIC5010000.0 [1]
(6S)-1-[(4-Amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acidIC5066.0 [1]
4-Ethyl-2-propyl-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylimidazole-5-carboxylic acidIC501000.0 [1]
2-[4-[[2-Butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acidKi480.0 [1]
2-[[4-[[2-Butyl-6-[methylcarbamoyl(pentyl)amino]benzimidazol-1-yl]methyl]phenyl]carbamoyl]-3,6-dichlorobenzoic acidKi730.0 [1]
CID 5311416Ki10000.0 [1]
(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acidIC501.74 [1]
2-(2,2-Diphenylacetyl)-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acidIC502.4 [1]
Nocathiacin acidIC501120.0 [1]
3-[2-Butyl-4-oxo-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]-1-methyl-1-propan-2-ylureaIC504500.0 [1]
N-Butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)-4-butoxybenzenesulfonamideKi0.5 [1]
2-Ethyl-7-methyl-5-(2-methylpropyl)-3-[(1S)-5-[2-(2H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]imidazo[4,5-b]pyridineKi10000.0 [1]
Angiotensin II, ala(8)-IC500.21 [1]
Tert-butyl N-[2-[4-[[3-butyl-1-[2-chloro-5-(propanoylamino)phenyl]-5-oxo-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylcarbamateIC505.8 [1]
Butyl N-[2-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)phenyl]sulfonylcarbamateKi8.2 [1]
N-(Benzenesulfonyl)-2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzamideIC50140.0 [1]
2-[(1S,18S,21E,28S,29S,30S)-30-[(2S,4S,5R,6S)-5-(Dimethylamino)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-9,52-dihydroxy-18-[(1R)-1-hydroxyethyl]-21-(1-methoxyethylidene)-16,19,26,31,42,46-hexaoxo-32,43,54-trioxa-3,13,23,49-tetrathia-7,17,20,27,45,51,52,55,56,57-decazadecacyclo[26.16.6.229,40.12,5.112,15.122,25.138,41.147,50.06,11.034,39]heptapentaconta-2(57),4,6,8,10,12(56),14,22(55),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-N-(3-morpholin-4-ylpropyl)-1,3-thiazole-4-carboxamideIC50260.0 [1]
3-Butyl-1-oxido-2-[4-[2-(2H-tetrazol-5-yl)phenyl]phenoxy]quinoxalin-1-iumKi4.5 [1]
(3R)-3-Amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidIC500.08 [1]
2-[(1S,18S,21E,28S,29S,30S)-30-[(2S,4S,5R,6S)-5-(Dimethylamino)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-52-hydroxy-18-[(1R)-1-hydroxyethyl]-9-methoxy-21-(1-methoxyethylidene)-16,19,26,31,42,46-hexaoxo-32,43,54-trioxa-3,13,23,49-tetrathia-7,17,20,27,45,51,52,55,56,57-decazadecacyclo[26.16.6.229,40.12,5.112,15.122,25.138,41.147,50.06,11.034,39]heptapentaconta-2(57),4,6,8,10,12(56),14,22(55),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-N-(3-morpholin-4-ylpropyl)-1,3-thiazole-4-carboxamideIC505070.0 [1]
(3S)-3-Amino-4-[[(2S)-1-[[(4R)-2-[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-4-[(4-hydroxyphenyl)methyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
2-[4-[[4-Methyl-6-(2-phenylethylcarbamoyl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acidIC5010000.0 [1]
5-Methylsulfanyl-2-propyl-3-[[4-[2-(propylcarbamoylsulfamoyl)phenyl]phenyl]methyl]imidazole-4-carboxylic acidIC50775.0 [1]
2-Butyl-5-methylsulfanyl-3-[[4-[2-(propylcarbamoylsulfamoyl)phenyl]phenyl]methyl]imidazole-4-carboxylic acidIC50920.0 [1]
Tert-butyl N-[2-[4-[[3-butyl-5-oxo-1-[5-(propanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylcarbamateIC5018.0 [1]
Methyl 5-ethyl-3-[[2-fluoro-4-[2-(3-methylbutoxycarbonylsulfamoyl)phenyl]phenyl]methyl]-2-propylimidazole-4-carboxylateIC501.0 [1]
2-Cyclopropylethyl N-[2-[4-[[2-ethyl-6-[[methyl(propan-2-yl)carbamoyl]amino]-4-oxoquinazolin-3-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC506.2 [1]
3-Butyl-1-chloro-5-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-5,6-dihydroimidazo[1,5-a]pyridine-7-carboxylic acidIC5010.0 [1]
Propan-2-yl N-[2-[4-[[3-butyl-5-oxo-1-[5-(propanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC502.7 [1]
Tert-butyl N-[2-[4-[[1-[2-bromo-5-(butylcarbamoyl)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC503.7 [1]
N-[2-[4-[[3-Butyl-1-[2-chloro-5-(propanoylamino)phenyl]-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2-chlorobenzamideIC503.1 [1]
Tert-butyl N-[2-[4-[[1-[2-bromo-5-(propanoylamino)phenyl]-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC502.3 [1]
Tert-butyl N-[2-[4-[[1-[5-(butylcarbamoyl)-2-(trifluoromethyl)phenyl]-5-oxo-3-propyl-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC502.6 [1]
N-[2-[4-[[1-[2-Bromo-5-(pentanoylamino)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2,5-difluorobenzamideIC501.5 [1]
(3S)-3-Amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-4-sulfanylbutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-4-sulfanylbutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acidKi2.1 [1]
Tert-butyl N-[2-[4-[[1-(5-benzamido-2-chlorophenyl)-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC5010.0 [1]
Propan-2-yl N-[2-[4-[[1-[2-bromo-5-(pentanoylamino)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC501.1 [1]
Tert-butyl N-[2-[4-[[3-butyl-1-[5-[(2-ethoxyacetyl)amino]-2-(trifluoromethyl)phenyl]-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC502.2 [1]
2-[4-[(2-Butyl-4-oxo-5H-imidazo[4,5-c]pyridin-3-yl)methyl]phenyl]benzoic acidIC5020.0 [1]
Tert-butyl N-[2-[4-[[1-[2-bromo-5-(propanoylamino)phenyl]-5-oxo-3-propyl-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC501.4 [1]
N-[2-[4-[[1-[2-Bromo-5-(pentanoylamino)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2-fluorobenzamideIC500.64 [1]
N-Butyl-3-[3-butyl-4-[[4-[2-[(2-chlorobenzoyl)sulfamoyl]phenyl]-2-fluorophenyl]methyl]-5-oxo-1,2,4-triazol-1-yl]-4-chlorobenzamideIC503.7 [1]
Tert-butyl N-[2-[4-[[1-[5-benzamido-2-(trifluoromethyl)phenyl]-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC506.3 [1]
N-Iso-Butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamideKi37.0 [1]
Tert-butyl N-[3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateKi63.0 [1]
N-Butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-butylthiophene-2-sulfonamideKi5.0 [1]
Ethyl N-[3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateKi10.0 [1]
N-Iso-propyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamideKi75.0 [1]
2-Butoxy-N-[3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylacetamideKi1.0 [1]
N-Butylsulfonyl-3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophene-2-carboxamideKi79.0 [1]
Butyl N-[3-[4-[(2-ethylbenzimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamateKi3.2 [1]
N-Butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-(2-Methoxy-ethyl)thiophene-2-sulfonamideKi86.0 [1]
1-Butyl-3-[3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylureaKi13.0 [1]
N-[2-[4-[[3-Butyl-5-oxo-1-[5-(propanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2-fluorobenzamideIC502.0 [1]
Tert-butyl N-[2-[4-[[1-[2-bromo-5-(pentanoylamino)phenyl]-5-oxo-3-propyl-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC502.2 [1]
Tert-butyl N-[2-[4-[[1-[5-benzamido-2-(trifluoromethyl)phenyl]-5-oxo-3-propyl-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamateIC505.3 [1]
4-Bromo-N-butyl-3-[4-[[4-[2-[(2,5-dichlorobenzoyl)sulfamoyl]phenyl]-2-fluorophenyl]methyl]-5-oxo-3-propyl-1,2,4-triazol-1-yl]benzamideIC502.0 [1]
l-Histidyl-l-prolyl-l-phenylalanineKi10000.0 [1]
N-Butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)-4-butylbenzenesulfonamideKi5.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ Angiotensin II type 2 (AT-2) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/angiotensin-ii-type-2-at-2-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Angiotensin II type 2 (AT-2) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/angiotensin-ii-type-2-at-2-receptor-inhibitors-ic50-ki.
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