Angiotensin-converting enzyme Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Captopril	IC50	20.0 [1]
	Captopril	Ki	2.0 [1]
	Enalaprilat	IC50	2.4 [1]
	Lisinopril	IC50	1.2 [1]
	Lisinopril	Ki	51.0 [1], 131.5 [2]
	Enalapril	IC50	140.0 [1]
	Ketoace	IC50	12.0 [1]
	Ketoace	Ki	45200.0 [1]
	(2S)-3-(4-Hydroxyphenyl)-2-[[(2R)-2-[[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoyl]amino]propanoic acid	Ki	4.0 [1]
	Omapatrilat	IC50	1.0 [1], 2.0 [2]
	Omapatrilat	Ki	0.01 [1], 0.02 [2], 6.0 [3]
	(2S)-2-[[(2R)-2-[[Hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid	Ki	3.6 [1], 36.0 [2], 500.0 [3], 1510.0 [4], 1520.0 [5]
	(2S)-2-[[(2R)-2-[[Hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoyl]amino]-3-phenylpropanoic acid	Ki	3.8 [1], 32.0 [2], 110.0 [3], 340.0 [4]
	Quinapril	IC50	8.3 [1]
	L-Alanyl-L-proline	IC50	42000.0 [1], 110000.0 [2], 229086.77 [3]
	L-Alanyl-L-proline	Ki	50000.0 [1]
	(4S,7S,10As)-4-[[(2S)-2-[[(2S)-1-[[(4S,7S,10aS)-7-carboxy-5-oxo-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepin-4-yl]amino]-1-oxo-3-phenylpropan-2-yl]disulfanyl]-3-phenylpropanoyl]amino]-5-oxo-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid	IC50	1800.0 [1], 2100.0 [2], 2200.0 [3], 2800.0 [4]
	Quinaprilat	IC50	2.8 [1], 2.9 [2], 280.0 [3]
	Val-trp	IC50	1584.89 [1], 1600.0 [2], 1700.0 [3]
	(2S)-1-[(2S)-3-[[(1R)-1-Benzamido-2-phenylethyl]-dihydroxysilyl]-2-methylpropanoyl]pyrrolidine-2-carboxylic acid	IC50	3.8 [1]
	2-[(3S)-2-Oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid	IC50	12.0 [1]
	Thiorphan	IC50	140.0 [1], 316.23 [2]
	(2-Mercaptomethyl-3-phenyl-propionyl)-glycine	IC50	140.0 [1], 860.0 [2]
	Moexipril	IC50	2.6 [1], 56.0 [2]
	Glycyl-L-proline	IC50	446683.59 [1]
	Glycyl-L-phenylalanine	IC50	602559.59 [1], 630957.34 [2]
	4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-	IC50	19.95 [1], 65.0 [2]
	Norathyriol	IC50	530800.0 [1]
	Norathyriol	Ki	250200.0 [1]
	Benzoylphenylalanyl-alanyl-proline	IC50	3.2 [1], 2700.0 [2]
	Val-pro	IC50	416869.38 [1]
	CID 9827219	Ki	7.0 [1], 7500.0 [2]
	3,4,5,6-Tetrahydroxyxanthone	IC50	238500.0 [1]
	3,4,5,6-Tetrahydroxyxanthone	Ki	126000.0 [1]
	1,3,5,6-Tetrahydroxyxanthone	IC50	69200.0 [1]
	1,3,5,6-Tetrahydroxyxanthone	Ki	34200.0 [1]
	Isoleucyl-Tyrosine	IC50	3700.0 [1], 3715.35 [2]
	Succinylproline	IC50	14500.0 [1], 33113.11 [2]
	N(alpha)-Phosphorylalanylproline	IC50	776.25 [1]
	N(alpha)-Phosphorylalanylproline	Ki	1.4 [1]
	L-Proline, 1-(3-mercapto-1-oxopropyl)-	IC50	16982.44 [1], 1800000.0 [2]
	1-(3-Mercaptopropanoyl)-6-methylpiperidine-2-carboxylic acid	IC50	1.0 [1], 20.0 [2]
	S-[3-(Benzylamino)-2-methyl-3-oxopropyl] ethanethioate	IC50	200000.0 [1], 500000.0 [2]
	N-Benzoylphenylalanyl-glycyl-proline	IC50	9400.0 [1]
	5-Bmopp	IC50	1.0 [1]
	(2S)-1-[(2R)-2-Methyl-3-sulfanylpropanoyl]-2,3-dihydroindole-2-carboxylic acid	IC50	3.7 [1], 6.03 [2]
	(2S)-1-[(2S)-2-[[(2S)-3-Phenyl-2-sulfanylpropanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acid	IC50	30.0 [1]
	(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-6-carboxylic acid	IC50	2000.0 [1], 8000.0 [2]
	1-(5-Benzoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid	IC50	70.0 [1]
	1-(5-Benzoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid	Ki	100.0 [1]
	S-(3-Anilino-2-methyl-3-oxopropyl) ethanethioate	IC50	300.0 [1], 2000.0 [2]
	1-(5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid	IC50	3.02 [1], 8.2 [2]
	1-(3-Mercapto-propionyl)-(R)-pyrrolidine-2-carboxylic acid	IC50	200.0 [1], 1819700.86 [2]
	1-(4-Carboxy-2-methyl-butyryl)-pyrrolidine-2-carboxylic acid	IC50	4897.79 [1], 4900.0 [2]
	L-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-5-oxo-	IC50	8.91 [1], 9.0 [2]
	(S)-1-((1S,5R)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid	IC50	3200.0 [1]
	Phe-Ala-Pro	IC50	1400.0 [1]
	2-Oxo-3-[(1-carboxy-3-phenylpropyl)amino]-2,3,4,5-tetrahydro-1H-1-benzazepine-1-acetic acid	IC50	1.7 [1], 10.0 [2]
	(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-6-carboxylic acid	IC50	4.0 [1], 1400.0 [2]
	(2S)-1-[(2S)-2-[[Hydroxy(2-phenylethyl)phosphoryl]amino]propanoyl]pyrrolidine-2-carboxylic acid	IC50	7.08 [1]
	(2S)-1-[(2S)-2-[[Hydroxy(2-phenylethyl)phosphoryl]amino]propanoyl]pyrrolidine-2-carboxylic acid	Ki	0.5 [1]
	2-(2-Benzyl-3-mercapto-5-phenyl-pentanoylamino)-propionic acid	IC50	4000.0 [1]
	(2S)-1-[(2R)-2-(Carboxymethylamino)propanoyl]pyrrolidine-2-carboxylic acid	IC50	2400.0 [1]
	(2S)-1-[(2R)-2-(1-Carboxyethylamino)propanoyl]pyrrolidine-2-carboxylic acid	IC50	90.0 [1]
	CID 44377139	IC50	688.0 [1]
	CID 44377139	Ki	520.0 [1]
	3-(4-Hydroxyphenyl)-2-(2-(3-mercapto-5-methylhexanamido)-3-phenylpropanamido)propanoic acid	IC50	2800.0 [1]
	2-(3-Mercapto-5-methylhexanamido)-3-phenylpropanoic acid	IC50	10000.0 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	490.0 [1]
	3,4,6,7-Tetrahydroxyxanthone	IC50	35400.0 [1]
	3,4,6,7-Tetrahydroxyxanthone	Ki	14200.0 [1]
	2-(1-Carboxymethyl-2-oxo-azonan-3-ylamino)-4-phenyl-butyric acid	IC50	8.1 [1], 1300.0 [2]
	2-(1-Carboxymethyl-2-oxo-azepan-3-ylamino)-4-phenyl-butyric acid	IC50	19.0 [1], 700.0 [2]
	[(1R)-1-[[(2S)-2-[[(2S,3S)-2-Acetamido-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-2-(4-hydroxyphenyl)ethyl]phosphonic acid	IC50	7.0 [1], 88.0 [2]
	N-Acetyl-L-Ile-L-Tyr-(R)-1-Amino-2-(4-Hydroxyphenyl)ethylphosphonic Acid	Ki	11.0 [1], 75.0 [2]
	2-(1-Carboxymethyl-2-oxo-azocan-3-ylamino)-4-phenyl-butyric acid	IC50	4.8 [1], 1700.0 [2]
	1-[5-[[6-Amino-2-(cyclobutanecarbonylamino)hexanoyl]amino]-4-oxo-6-phenylhexanoyl]pyrrolidine-2-carboxylic acid	IC50	7.0 [1], 7.6 [2]
	2-(1-Carboxymethyl-2-oxo-pyrrolidin-3-ylamino)-4-phenyl-butyric acid	IC50	12000.0 [1], 19000.0 [2]
	2-(1-Carboxymethyl-2-oxo-piperidin-3-ylamino)-4-phenyl-butyric acid	IC50	430.0 [1], 1700.0 [2]
	(S)-3-Biphenyl-4-yl-2-((S)-2-mercapto-3-phenyl-propionylamino)-propionic acid	IC50	80.0 [1]
	(S)-3-Biphenyl-4-yl-2-((S)-2-mercapto-3-phenyl-propionylamino)-propionic acid	Ki	30.0 [1]
	(2S)-2-[[(1S,2R)-2-[Hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]cyclopentanecarbonyl]amino]-3-(1H-indol-3-yl)propanoic acid	Ki	3.0 [1], 2500.0 [2]
	(2S)-2-[[(1S)-2-[Hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]cyclopentanecarbonyl]amino]-3-(1H-indol-3-yl)propanoic acid	Ki	3.0 [1], 10000.0 [2]
	[(1R)-1-[[(2S)-2-[[(2S,3S)-2-Acetamido-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-2-(4-hydroxyphenyl)ethyl]phosphonic acid	IC50	76.0 [1]
	[(1R)-1-[[(2S)-2-[[(2S,3S)-2-Acetamido-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-2-(4-hydroxyphenyl)ethyl]phosphonic acid	Ki	21.0 [1]
	Edetic acid	IC50	14000.0 [1]
	Proline	Ki	86000.0 [1]
	Losartan	IC50	19.0 [1]
	Gallic acid	IC50	7700000.0 [1]
	Ramipril	IC50	4.0 [1]
	Dasatinib	Ki	715000.0 [1]
	Perindopril	IC50	1.5 [1]
	Sitagliptin	IC50	11000.0 [1]
	Novobiocin	Ki	167000.0 [1]
	Ellagic acid	IC50	5000000.0 [1]
	Benazepril	IC50	1.7 [1]
	Trandolapril	IC50	0.93 [1]
	Glycylglycine	IC50	7244359.6 [1]
	Teprotide	IC50	220.0 [1]
	Fosinopril	IC50	1.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Angiotensin-converting enzyme Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/angiotensin-converting-enzyme-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Angiotensin-converting enzyme Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/angiotensin-converting-enzyme-inhibitors-ic50-ki.
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