Angiotensin-converting enzyme 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(S,S)-2-{1-Carboxy-2-[3-(3,5-dichloro-benzyl)-3H-imidazol-4-YL]-ethylamino}-4-methyl-pentanoic acid	IC50	0.44 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	1.5 [1]
	CID 1382255	IC50	62000.0 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-4-methylpentanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	0.35 [1]
	CID 44377139	Ki	1400.0 [1]
	N-(2-Aminoethyl)-1-aziridineethanamine	IC50	57000.0 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamidopropanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	7.5 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-6-aminohexanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	6.5 [1]
	(4S)-4-Acetamido-5-[(2S)-2-[[(2S)-2-carboxy-3-phenylpropyl]-hydroxyphosphoryl]pyrrolidin-1-yl]-5-oxopentanoic acid	Ki	7.0 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	5.2 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-3-phenylpropanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	5.2 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-3-methylbutanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	6.6 [1]
	(2S)-2-[[[(2S)-1-[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	2.1 [1]
	(2S)-2-[[[(1S)-1-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-2-phenylethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	920.0 [1]
	(2S)-2-[[[(1S)-1-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	800.0 [1]
	(2S)-2-Benzyl-3-[hydroxy-[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]phosphoryl]propanoic acid	Ki	300.0 [1]
	(2S)-2-[[Hydroxy-[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]phosphoryl]methyl]-4-methylpentanoic acid	Ki	300.0 [1]
	(2S)-3-[Hydroxy-[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]phosphoryl]-2-methylpropanoic acid	Ki	3000.0 [1]
	(2S)-2-Benzyl-3-[hydroxy-[(1S)-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoic acid	Ki	10000.0 [1]
	(2S)-2-Benzyl-3-[hydroxy-[(1S)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoic acid	Ki	10000.0 [1]
	(2S)-2-Benzyl-3-[hydroxy-[(1S)-3-methyl-1-(phenylmethoxycarbonylamino)butyl]phosphoryl]propanoic acid	Ki	8000.0 [1]
	(2S)-2-[[[(1S)-1-Aminoethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	10000.0 [1]
	(2S)-2-[[[(1S)-1-Amino-2-phenylethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	10000.0 [1]
	(2S)-2-[[[(1S)-1-Amino-3-methylbutyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid	Ki	10000.0 [1]
	(2S)-2-Benzyl-3-[hydroxy-[(2S)-pyrrolidin-2-yl]phosphoryl]propanoic acid	Ki	10000.0 [1]
	(2S)-2-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	1.5 [1]
	(2S)-2-[[(2S)-4,4-Dimethyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	7.1 [1]
	(S)-3-Biphenyl-4-yl-2-((S)-2-mercapto-3-phenyl-propionylamino)-propionic acid	Ki	86.0 [1]
	2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]acetic acid	Ki	90.0 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	14.0 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-phenylpropanoic acid	Ki	1.5 [1]
	(2S)-3-(4-Hydroxyphenyl)-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	1.3 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-naphthalen-1-ylpropanoic acid	Ki	2.2 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-naphthalen-2-ylpropanoic acid	Ki	2.4 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(2-phenylphenyl)propanoic acid	Ki	37.0 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(3-phenylphenyl)propanoic acid	Ki	2.2 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(2-phenoxyphenyl)propanoic acid	Ki	0.9 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(3-phenoxyphenyl)propanoic acid	Ki	5.8 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenoxyphenyl)propanoic acid	Ki	2.2 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(2-phenylmethoxyphenyl)propanoic acid	Ki	6.0 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(3-phenylmethoxyphenyl)propanoic acid	Ki	2.4 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylmethoxyphenyl)propanoic acid	Ki	2.7 [1]
	(2S)-3-[4-[(4-Fluorophenyl)methoxy]phenyl]-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	2.5 [1]
	(2S)-3-[4-[(2,4-Difluorophenyl)methoxy]phenyl]-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	2.0 [1]
	(2S)-3-[4-[(3,4-Difluorophenyl)methoxy]phenyl]-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	0.85 [1]
	(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid	Ki	35.0 [1]
	(2S)-3-[4-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]phenyl]-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid	Ki	84.0 [1]
	(4S)-4-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-5-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(3S,6S,9S,12S,15S,21S,24S,27S,30R,35R,38S,41S)-27-(4-aminobutyl)-6-(3-carbamimidamidopropyl)-35-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-(2-oxopropylamino)propan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl]-38-(hydroxymethyl)-9,12-bis[(4-hydroxyphenyl)methyl]-21,24-bis(1H-indol-3-ylmethyl)-3-(2-methylpropyl)-2,5,8,11,14,20,23,26,29,37,40-undecaoxo-32,33-dithia-1,4,7,10,13,19,22,25,28,36,39-undecazatricyclo[39.3.0.015,19]tetratetracontan-30-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-carboxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid	IC50	10.0 [1]
	2-[[[(1S)-1-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutyl]-hydroxyphosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoic acid	Ki	220.0 [1]
	2-[[[(2S)-1-[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoic acid	Ki	0.4 [1]
	2-[[[(2S)-1-[(2S)-2-Acetamido-4-methylpentanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoic acid	Ki	1.25 [1]
	(2S)-2-[[(2S)-2-Cyclohexyl-2-sulfanylacetyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	65.0 [1]
	(2S)-2-[[(2S)-2-Cyclobutyl-2-sulfanylacetyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	2.4 [1]
	(2S)-2-[[(2S)-2-Cyclopentyl-2-sulfanylacetyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	1.8 [1]
	(2S)-2-[[(2S,3S)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	1.6 [1]
	(2S)-3-(4-Phenylphenyl)-2-[[(2S)-2-sulfanylhexanoyl]amino]propanoic acid	Ki	1.8 [1]
	(2S)-2-[(2-Methyl-2-sulfanylpropanoyl)amino]-3-(4-phenylphenyl)propanoic acid	Ki	2300.0 [1]
	(2S)-3-(4-Phenylphenyl)-2-[[(2S)-2-sulfanylbutanoyl]amino]propanoic acid	Ki	1.4 [1]
	(2S)-3-(4-Phenylphenyl)-2-[[(2S)-2-sulfanylpropanoyl]amino]propanoic acid	Ki	6.9 [1]
	(2S)-3-(4-Phenylphenyl)-2-[(2-sulfanylacetyl)amino]propanoic acid	Ki	320.0 [1]
	(2S)-3-(4-Phenylphenyl)-2-[[(2S)-4-phenyl-2-sulfanylbutanoyl]amino]propanoic acid	Ki	860.0 [1]
	(2S)-2-[[(2S)-3-Naphthalen-2-yl-2-sulfanylpropanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	550.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-2-sulfanylpropanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	420.0 [1]
	(2S)-3-(4-Phenylphenyl)-2-[[(2S)-2-phenyl-2-sulfanylacetyl]amino]propanoic acid	Ki	84.0 [1]
	(2S)-2-[[(2S)-4-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acid	Ki	1.4 [1]
	(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carboxylic acid	Ki	2.8 [1]
	N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 67 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Angiotensin-converting enzyme 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/angiotensin-converting-enzyme-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Angiotensin-converting enzyme 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/angiotensin-converting-enzyme-2-inhibitors-ic50-ki.
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