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Alpha-L-fucosidase I Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(2S,3R,4S,5R)-2-Methylpiperidine-3,4,5-triolIC50140.0 [1], 410.0 [2]
(2S,3R,4S,5R)-2-Methylpiperidine-3,4,5-triolKi6.2 [1]
(2S)-2-Amino-3-hydroxy-N-[[3,4,5-trihydroxy-2-(hydroxymethyl)-6-methylpiperidin-2-yl]methyl]propanamideIC5020.0 [1], 40.0 [2], 56.0 [3]
(2S)-2-Amino-3-hydroxy-N-[[3,4,5-trihydroxy-2-(hydroxymethyl)-6-methylpiperidin-2-yl]methyl]propanamideKi19.0 [1], 30.0 [2], 47.0 [3]
(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidin-1-yl)-acetaldehydeIC504.0 [1], 11.0 [2]
(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidin-1-yl)-acetaldehydeKi1.5 [1], 8.0 [2], 11.0 [3]
Ethyl 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoateIC50200000.0 [1], 300000.0 [2]
Ethyl 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoateKi9000.0 [1], 15000.0 [2]
5-[(2R,3S,4R)-3,4-Dihydroxypyrrolidin-2-yl]-N,N-diethyl-2-methyl-3-furamideIC5085000.0 [1], 220000.0 [2]
5-[(2R,3S,4R)-3,4-Dihydroxypyrrolidin-2-yl]-N,N-diethyl-2-methyl-3-furamideKi9100.0 [1], 20100.0 [2]
5-[(2R,3S,4R)-3,4-Dihydroxypyrrolidin-2-yl]-N-isopropyl-2-methyl-3-furamideIC5040000.0 [1], 80000.0 [2]
5-[(2R,3S,4R)-3,4-Dihydroxypyrrolidin-2-yl]-N-isopropyl-2-methyl-3-furamideKi3000.0 [1], 5300.0 [2]
Ethyl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateIC50200000.0 [1], 300000.0 [2]
Ethyl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateKi9000.0 [1], 15000.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-N,N-diethyl-2-methylfuran-3-carboxamideIC50110000.0 [1], 220000.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-N,N-diethyl-2-methylfuran-3-carboxamideKi9100.0 [1], 20100.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-2-methyl-N-propan-2-ylfuran-3-carboxamideIC5040000.0 [1], 80000.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-2-methyl-N-propan-2-ylfuran-3-carboxamideKi3000.0 [1], 5300.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-N-ethyl-2-methylfuran-3-carboxamideIC5040000.0 [1], 80000.0 [2]
5-(3,4-Dihydroxypyrrolidin-2-yl)-N-ethyl-2-methylfuran-3-carboxamideKi3200.0 [1], 4800.0 [2]
Propan-2-yl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateIC5050000.0 [1], 160000.0 [2]
Propan-2-yl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateKi4900.0 [1], 8600.0 [2]
Methyl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateIC50100000.0 [1], 150000.0 [2]
Methyl 5-(3,4-dihydroxypyrrolidin-2-yl)-2-methylfuran-3-carboxylateKi6500.0 [1], 13800.0 [2]
1-DeoxymannojirimycinIC50221000.0 [1]
1-DeoxymannojirimycinKi4700.0 [1], 30000.0 [2]
4-Methyl-6-octylamino-cyclohexane-1,2,3-triolIC50110.0 [1], 5500.0 [2]
4-Methyl-6-octylamino-cyclohexane-1,2,3-triolKi16.0 [1]
(1R,2R,3R,4S,6R)-4-Amino-6-methylcyclohexane-1,2,3-triolIC5025000.0 [1]
(1R,2R,3R,4S,6R)-4-Amino-6-methylcyclohexane-1,2,3-triolKi12.0 [1], 2900.0 [2]
(1R,2R,3R,4R,6R)-4-Amino-6-methylcyclohexane-1,2,3-triolIC509300.0 [1]
(1R,2R,3R,4R,6R)-4-Amino-6-methylcyclohexane-1,2,3-triolKi12.0 [1], 1000.0 [2]
(3R,4S,5R)-2-(Hydroxymethyl)-6-methylpiperidine-3,4,5-triolKi5.8 [1]
2-Aminomethylsulfanyl-6-methyl-tetrahydro-pyran-3,4,5-triolKi5900.0 [1], 6100.0 [2], 6800.0 [3]
N-(3,4,5-Trihydroxy-6-methyl-tetrahydro-pyran-2-ylsulfanylmethyl)-acetamideKi3900.0 [1], 4600.0 [2], 5600.0 [3]
3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidine-2-carbonitrileIC5075.0 [1], 110.0 [2], 122.0 [3]
2-Aminomethyl-2-hydroxymethyl-6-methyl-piperidine-3,4,5-triolIC5080.0 [1], 160.0 [2], 206.0 [3]
Benzyl N-[2-oxo-2-[[3,4,5-trihydroxy-2-(hydroxymethyl)-6-methylpiperidin-2-yl]methylamino]ethyl]carbamateIC5040.0 [1], 190.0 [2], 200.0 [3]
2-Amino-N-[[3,4,5-trihydroxy-2-(hydroxymethyl)-6-methylpiperidin-2-yl]methyl]acetamideIC5050.0 [1], 116.0 [2], 170.0 [3]
L-FucoseKi300000.0 [1]
1-DeoxynojirimycinIC5026000.0 [1]
1-DeoxynojirimycinKi100000000.0 [1]
(2S,3S,4R,5S)-2-(Hydroxymethyl)-5-methylpyrrolidine-3,4-diolKi1400.0 [1], 4000.0 [2]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4S,5R)-IC503500.0 [1]
(4R)-2-[(3R)-4,5-Dihydroxy-6-(hydroxymethyl)-2-prop-2-enoxyoxan-3-yl]oxy-6-methylthiane-3,4,5-triolKi210.0 [1], 30000.0 [2]
(4S,5R)-2-Methyl-piperidine-3,4,5-triolKi5.0 [1], 6.0 [2]
(1R,2S,3S)-4-Benzylamino-6-methyl-cyclohexane-1,2,3-triolIC501000.0 [1]
(1R,2S,3S)-4-Benzylamino-6-methyl-cyclohexane-1,2,3-triolKi69.0 [1]
(1R,2S,3S)-4-Butylamino-6-methyl-cyclohexane-1,2,3-triolIC50920.0 [1]
(1R,2S,3S)-4-Butylamino-6-methyl-cyclohexane-1,2,3-triolKi74.0 [1]
(1S,2S,3R)-4-Methyl-6-nonylamino-cyclohexane-1,2,3-triolIC50240.0 [1]
(1S,2S,3R)-4-Methyl-6-nonylamino-cyclohexane-1,2,3-triolKi110.0 [1]
4-Methyl-6-phenethylamino-cyclohexane-1,2,3-triolIC50240.0 [1]
4-Methyl-6-phenethylamino-cyclohexane-1,2,3-triolKi32.0 [1]
(1R,2S,3S)-4-Heptylamino-6-methyl-cyclohexane-1,2,3-triolIC50270.0 [1]
(1R,2S,3S)-4-Heptylamino-6-methyl-cyclohexane-1,2,3-triolKi48.0 [1]
(1R,2S,3S)-4-Ethylamino-6-methyl-cyclohexane-1,2,3-triolIC5021000.0 [1]
(1R,2S,3S)-4-Ethylamino-6-methyl-cyclohexane-1,2,3-triolKi180.0 [1]
5-Methylpiperidine-3,4-diolIC5026000.0 [1]
5-Methylpiperidine-3,4-diolKi8400.0 [1]
6-Methylthiane-2,3,4,5-tetrolKi42000.0 [1], 80000.0 [2]
2,6-Diiminohexane-1,3,4,5-tetrolKi7000.0 [1], 11000.0 [2]
(2R,3S,4S,5S,6S)-6-Methyl-5-sulfanyloxane-2,3,4-triolKi42000.0 [1], 84000.0 [2]
1-(4-Hydroxy-2-methyl-3,4-dihydro-2H-pyran-3-yl)-ethanoneKi90000.0 [1], 26000000.0 [2]
MigalastatKi34000000.0 [1]
N-Methyl-1-deoxynojirimycinKi5300000.0 [1]
FagomineIC50140000.0 [1]
Piperidine-3,4,5-triolIC501000000.0 [1]
3-Epi-fagomineIC501000000.0 [1]
2,5-Pyrrolidinedimethanol, 3,4-dihydroxy-Ki910000.0 [1]
(3R,4S)-Pyrrolidine-3,4-diolKi1000000.0 [1]
(2R,3R,4R,5R,6S)-2-(Hydroxymethyl)-6-methylpiperidine-3,4,5-triolKi80.0 [1]
1,6-DideoxynojirimycinKi1700000.0 [1]
(2R,3R,5R,6R)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triolIC5030000.0 [1]
(2R,3R,5R,6S)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triolIC502600.0 [1]
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-methylpyrrolidine-3,4-diolKi9000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4R,5R)-IC50150000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4S,5S)-Ki90000000.0 [1]
(2R,3S,4R,5S)-2-Methylpiperidine-3,4,5-triolKi7900000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4S,5S)-IC50194000.0 [1]
(R)-Azepane-3,4,5,6-tetraolKi28000.0 [1]
(3R,4R,6R)-5,5-Difluoro-6-(hydroxymethyl)piperidine-3,4-diolKi1000000.0 [1]
(3R,4R,6S)-5,5-Difluoro-6-(hydroxymethyl)piperidine-3,4-diolKi1000000.0 [1]
(3S,4R,6R)-5,5-Difluoro-6-(hydroxymethyl)piperidine-3,4-diolKi1000000.0 [1]
2-Benzylimino-5-methyl-3a,4,5,6,7,7a-hexahydro-3H-1,3-benzoxazole-6,7-diolIC5072000.0 [1]
2-Butylimino-5-methyl-3a,4,5,6,7,7a-hexahydro-3H-1,3-benzoxazole-6,7-diolIC50140000.0 [1]
(2S,3R,4R,5R,6R)-2-Ethyl-6-(hydroxymethyl)piperidine-3,4,5-triolIC5083000.0 [1]
(1S,2R,3R,5S,7S,8R)-3,5-Bis(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1H-pyrrolizine-1,2,7-triolIC5017000.0 [1]
(S)-5-Methyl-piperidine-3,4-diolKi8400.0 [1]
(2R,3R)-4-Amino-6-methyl-cyclohexane-1,2,3-triolKi230.0 [1]
(R)-4-Amino-5-methyl-cyclopentane-1,2,3-triolKi15000.0 [1]
(R)-4-Benzylamino-5-methyl-cyclopentane-1,2,3-triolKi680.0 [1]
(R)-2-Methyl-6-(4-nitro-phenylsulfanyl)-tetrahydro-thiopyran-3,4,5-triolKi3300.0 [1]
(R)-1-Benzyl-azepane-3,4,5,6-tetraolKi23400.0 [1]
(R)-6-Methyl-tetrahydro-thiopyran-2,3,4,5-tetraolKi42000.0 [1]
N-((3R,4R)-3,4,5-Trihydroxy-piperidin-2-ylmethyl)-acetamideKi4000.0 [1]
2-Methyl-pyrrolidine-3,4-diolKi2000.0 [1]
(4R,5R)-Piperidine-3,4,5-triolKi24000.0 [1]
5-(3,4-Dihydroxypyrrolidin-2-yl)-2-methyl-N-phenylfuran-3-carboxamideIC501000000.0 [1]
CID 44319866Ki160.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Alpha-L-fucosidase I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/alpha-l-fucosidase-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Alpha-L-fucosidase I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-l-fucosidase-i-inhibitors-ic50-ki.
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