Alpha-ketoglutarate-dependent dioxygenase FTO Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sodium	IC50	11000.0 [1]
	Glutamic acid	IC50	1000000.0 [1]
	D-Lactic acid	IC50	1000000.0 [1]
	D-Glutamic acid	IC50	1000000.0 [1]
	Citric acid	IC50	300000.0 [1]
	Pyruvic acid	IC50	1000000.0 [1]
	Malic acid	IC50	1000000.0 [1]
	Fumaric acid	IC50	150000.0 [1]
	(2R)-2-Hydroxypentanedioic acid	IC50	1000000.0 [1]
	N-Oxalylglycine	IC50	44000.0 [1]
	cis-Aconitic acid	IC50	1000000.0 [1]
	Pyridine-2,4-dicarboxylic acid	IC50	8300.0 [1]
	Roxadustat	IC50	9800.0 [1]
	8-Hydroxy-5-quinolinecarboxylic acid	IC50	3300.0 [1]
	N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycine	IC50	2800.0 [1]
	(2S)-2-Hydroxypentanedioic acid	IC50	320000.0 [1]
	(2s)-2-{[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)carbonyl]amino}propanoic Acid	IC50	110000.0 [1]
	(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid	IC50	60000.0 [1]
	(S)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid	IC50	160000.0 [1]
	(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid	IC50	120000.0 [1]
	N-[(3-Hydroxypyridin-2-Yl)carbonyl]glycine	IC50	15000.0 [1]
	(2R)-2-[(3-Hydroxypyridine-2-carbonyl)amino]-3-(naphthalen-2-ylmethylsulfanyl)propanoic acid	IC50	92000.0 [1]
	[[3-Hydroxy-5-(2-naphthyl)pyridine-2-yl]carbonylamino]acetic acid	IC50	43000.0 [1]
	(2R)-2-[(1-Chloro-4-hydroxyisoquinoline-3-carbonyl)amino]-3-phenylpropanoic acid	IC50	38000.0 [1]
	(2S)-2-[(1-Chloro-4-hydroxyisoquinoline-3-carbonyl)amino]-3-phenylpropanoic acid	IC50	84000.0 [1]
	8-Hydroxy-N-methylquinoline-5-sulfonamide	IC50	18000.0 [1]
	4-[2-[3-[[(2S)-4-[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4-oxobutanoic acid	IC50	1000000.0 [1]
	L-Threo-isocitric acid	IC50	1000000.0 [1]
	1,8-Dihydroxy-9,10-dioxoanthracene-2-carboxylic acid	IC50	9000.0 [1]
	[[3-Hydroxy-5-(6-hydroxy-2-naphthyl)pyridine-2-yl]carbonylamino]acetic acid	IC50	96000.0 [1]
	5-Quinolinesulfonamide, 8-hydroxy-	IC50	23000.0 [1]
	(E)-4-Oxo-4-[2-[5-(2-phenoxyphenyl)pyridine-2-carbonyl]hydrazinyl]but-2-enoic acid	IC50	120000.0 [1]
	(2R,3S)-3-(Dihydroxymethyl)-2-hydroxypentanedioic acid	IC50	1000000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 33 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-ketoglutarate-dependent dioxygenase FTO Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 29 Mar. 2025, https://www.aatbio.com/data-sets/alpha-ketoglutarate-dependent-dioxygenase-fto-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 29). Quest Database™ Alpha-ketoglutarate-dependent dioxygenase FTO Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-ketoglutarate-dependent-dioxygenase-fto-inhibitors-ic50-ki.
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