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Alpha-galactosidase A Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
2,5-Dideoxy-2,5-imino-D-altritolIC50690.0 [1], 750.0 [2], 1000.0 [3]
2,5-Dideoxy-2,5-imino-D-altritolKi500.0 [1]
MigalastatIC5013.0 [1], 42.0 [2], 70.0 [3]
5-Cyclohexyl-N-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]pentanamideIC502100.0 [1], 10400.0 [2]
5-Cyclohexyl-N-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]pentanamideKi2000.0 [1], 7700.0 [2]
(2R,3R,4S,5R)-2-(Aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diolIC5053.0 [1], 670.0 [2]
(2S,3R,4S,5R)-2-(Aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diolIC5010600.0 [1], 34200.0 [2]
(2R,3R,4S,5S)-2-(Aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diolIC5014000.0 [1], 266000.0 [2]
(E)-N-[[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamideIC501100.0 [1], 5000.0 [2]
N-[[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3-(2,4,5-trimethoxyphenyl)propanamideIC507700.0 [1], 30400.0 [2]
(E)-3-(5-Bromo-2-methoxyphenyl)-N-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]prop-2-enamideIC503000.0 [1], 32800.0 [2]
N-[[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3-(3-methoxyphenyl)propanamideIC5013000.0 [1], 19100.0 [2]
1-DeoxynojirimycinKi18000.0 [1]
D-Galacto-IsofagomineKi2000000.0 [1]
Piperidine-3,4,5-triolIC5040000.0 [1]
(2R,3S,5S,6R)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triolIC5080000.0 [1]
(3As,6S,6aS)-3-(hydroxymethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,2]oxazole-5,6-diolIC50805000.0 [1]
Dideoxy-Imino-LyxitolIC509500.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3S,4S,5S)-IC50920000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3S,4S,5R)-IC50390000.0 [1]
(3R,4S,5R,6R)-6-(4-Aminobutyl)-5-(hydroxymethyl)piperidine-3,4-diolKi2000000.0 [1]
(3R,4S,5R,6R)-6-(2-Hydroxyethyl)-5-(hydroxymethyl)piperidine-3,4-diolKi2000000.0 [1]
N-[4-[(2R,3R,4S,5R)-4,5-Dihydroxy-3-(hydroxymethyl)piperidin-2-yl]butyl]-5-(dimethylamino)naphthalene-1-sulfonamideKi2000000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4S,5R)-IC5045000.0 [1]
(E)-3-(5-Bromo-2-methoxyphenyl)-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]prop-2-enamideIC503500.0 [1]
5-Cyclohexyl-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]pentanamideIC503100.0 [1]
(E)-3-[4-(Trifluoromethyl)phenyl]-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]prop-2-enamideIC501200.0 [1]
(E)-3-(3-Bromophenyl)-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]prop-2-enamideKi3500.0 [1]
3,7-Dimethyl-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]oct-6-enamideIC5013000.0 [1]
(2R,3S,4R)-2-[[4-[4-(Hydroxymethyl)phenyl]triazol-1-yl]methyl]pyrrolidine-3,4-diolIC50159000.0 [1]
(2R,3S,4R)-2-[[4-(4-Methoxyphenyl)triazol-1-yl]methyl]pyrrolidine-3,4-diolIC50185000.0 [1]
3-Cyclopentyl-N-[[(2R,3S,4R,5S)-3,4,5-trihydroxypiperidin-2-yl]methyl]propanamideIC504100.0 [1]
(2R,3S,4R)-2-[(4-Phenyltriazol-1-yl)methyl]pyrrolidine-3,4-diolIC50171000.0 [1]
N-[[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]acetamideIC5022100.0 [1]
(R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triolIC506400.0 [1]
beta-1-C-Butyl-1-deoxygalactonojirimycinIC5015000.0 [1]
(2R,3S,4R,5S,6S)-6-But-3-enyl-2-(hydroxymethyl)-5-methylpiperidine-3,4-diolIC5039000.0 [1]
(2R,3R,4S,5S,6R)-2-[[(2R,3R,6S)-6-Ethyl-3-hydroxypiperidin-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50224000.0 [1]
(2S,3R)-2-Amino-3-[[(2R,3S,4R,5R,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy]butanoic acidKi300000.0 [1]
2-Amino-3-(3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethoxy)-propionic acidKi400000.0 [1]
5-Methylpiperidine-3,4-diolIC501000000.0 [1]
(3s,4r,5r,6s)-Azepane-3,4,5,6-TetrolKi67000.0 [1]
5-Methylene-piperidine-3,4-diolIC501000000.0 [1]
1-Butyl-5-methyl-piperidine-3,4-diolIC501000000.0 [1]
5-Methoxy-piperidine-3,4-diolIC501000000.0 [1]
1-Butyl-piperidine-3,4,5-triolIC50725000.0 [1]
Items per page: 1 - 10 of 46
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References

This online tool may be cited as follows

MLA

"Quest Database™ Alpha-galactosidase A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/alpha-galactosidase-a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Alpha-galactosidase A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-galactosidase-a-inhibitors-ic50-ki.
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