Alpha-2c adrenergic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Yohimbine	IC50	27.1 [1]
	Yohimbine	Ki	2.3 [1]
	Clonidine	Ki	9.33 [1], 30.0 [2], 56.23 [3], 160.0 [4]
	Terazosin	Ki	78.0 [1], 170.0 [2], 213.0 [3], 223.87 [4], 878.0 [5]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	0.5 [1], 4.8 [2], 6.2 [3], 8.8 [4]
	Mianserin	IC50	42.66 [1]
	Mianserin	Ki	3.8 [1], 26.0 [2]
	Idazoxan	IC50	53.7 [1]
	Idazoxan	Ki	17.78 [1], 19.0 [2]
	2-[1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	85.11 [1]
	Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	370.0 [1], 371.54 [2], 912.0 [3], 1320.0 [4]
	2-[1-(2-Biphenylyloxy)ethyl]-2-imidazoline	Ki	199.53 [1]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-2-methyl-3-phenylprop-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	0.1 [1], 0.2 [2]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-3-phenylbut-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	0.2 [1], 0.6 [2]
	Clozapine	Ki	1.14 [1], 2.9 [2], 100.0 [3]
	Risperidone	Ki	1.39 [1], 3.2 [2], 10.0 [3]
	Olanzapine	Ki	77.0 [1], 82.0 [2], 100.0 [3]
	Prazosin	Ki	24.0 [1], 94.0 [2], 95.0 [3]
	Phentolamine	Ki	8.4 [1], 16.0 [2], 80.3 [3]
	Oxymetazoline	Ki	1.0 [1], 58.88 [2], 383.0 [3]
	3-[2-[1-(4,5-Dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol	Ki	17.78 [1]
	2-[1-[2-(3-Nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	234.42 [1]
	2-[(1S)-1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	70.79 [1]
	2-[(1R)-1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	177.83 [1]
	2-[1-[2-(Cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	275.42 [1]
	N-(4,5-Dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amine	Ki	27.0 [1], 28.18 [2]
	(3R,3As)-7,8-dimethoxy-3-[[4-(naphthalen-2-ylmethyl)piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	0.8 [1], 3.1 [2]
	Quetiapine	Ki	61.1 [1], 100.0 [2]
	Rauwolscine	IC50	16.0 [1]
	Rauwolscine	Ki	1.0 [1]
	Mirtazapine	IC50	199.53 [1]
	Mirtazapine	Ki	18.0 [1]
	Brimonidine	Ki	44.0 [1], 83.18 [2]
	Rilmenidine	Ki	12.59 [1], 288.4 [2]
	Clemastine	Ki	14.0 [1], 223.87 [2]
	Cirazoline	Ki	549.54 [1]
	Niguldipine	Ki	330.0 [1], 370.0 [2]
	Unii-22xbk6DY1E	Ki	64.0 [1]
	N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine	Ki	27.99 [1], 28.0 [2]
	N,N-Diallyl-5-methoxytryptamine	Ki	501.19 [1], 1479.11 [2]
	2,6,3,5-Ethanediylidenepentaleno(1,6-bc)pyrrol-2(1H)-ol, octahydro-1-(phenylmethyl)-	Ki	682.0 [1]
	1H-Imidazole, 4,5-dihydro-2-(1-phenoxyethyl)-	Ki	263.03 [1]
	2-(1-Benzofuran-6-yl)-N-[[(1R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl]-N-methylethanamine	Ki	2.1 [1]
	9-Acridinamine, N-(4-(4-ethyl-1-piperazinyl)phenyl)-	Ki	36.98 [1], 37.0 [2]
	[4-(4-Methylpiperazinyl)phenyl]-4-quinolylamine	Ki	1698.24 [1], 1700.0 [2]
	2-[(1S)-1-(2-Phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	302.0 [1]
	N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine	IC50	1862.09 [1]
	4-(5-Fluoro-2-indanylmethyl)-2-imidazoline	Ki	19.0 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	323.0 [1], 323.59 [2]
	2-[(1R)-1-(2-Phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	977.24 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	165.0 [1], 323.59 [2]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(2,3,7-trimethylquinolin-4-yl)amine	Ki	15.0 [1]
	{4-[4-(3,4-Dimethylpiperazin-1-yl)phenylamino]-2-methylquinolin-3-yl}methanol	Ki	7.5 [1]
	N-[4-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)phenyl]-2,3-dimethylquinolin-4-amine	Ki	2.3 [1]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(2-methyl-3-phenylquinolin-4-yl)amine	Ki	5.0 [1]
	(3-Ethyl-2-methylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)-phenyl]amine	Ki	25.0 [1]
	(2,3-Dimethylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)phenyl] amine	Ki	34.99 [1], 35.0 [2]
	(3-Isopropyl-2-methylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)phenyl]amine	Ki	52.0 [1]
	{7-Chloro-4-[4-(3,3,4-trimethylpiperazin-1-yl)phenylamino]-quinolin-3-yl}methanol	Ki	5.9 [1]
	{4-[4-(3,4-Dimethylpiperazin-1-yl)phenylamino]-6-fluoroquinolin-3-yl}methanol	Ki	42.95 [1], 43.0 [2]
	7-Chloro-N-[4-(3,4-dimethylpiperazin-1-yl)phenyl]-2,3-dimethylquinolin-4-amine	Ki	8.3 [1]
	(2-Methyl-3-phenylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)-phenyl]amine	Ki	34.99 [1], 35.0 [2]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(2,3,7,8-tetramethylquinolin-4-yl)amine	Ki	5.0 [1]
	(3-Methylquinolin-4-yl)-[4-(3,3,4-trimethylpiperazin-1-yl)phenyl]amine	Ki	5.39 [1], 5.4 [2]
	{4-[4-(3,3,4-Trimethylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol	Ki	6.4 [1]
	{6-Fluoro-4-[4-(3,3,4-trimethylpiperazin-1-yl)phenylamino]-quinolin-3-yl}methanol	Ki	50.0 [1]
	1-Benzyl-4-chroman-2-ylmethyl-piperazine	Ki	19.6 [1], 21.1 [2]
	2-[1-[2-(3-Fluorophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	16.98 [1]
	3-[2-[1-(4,5-Dihydro-1H-imidazol-2-yl)ethoxy]phenyl]pyridine	Ki	64.57 [1]
	2-[1-(2-Thiophen-3-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	131.83 [1]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(2,3,5,7-tetramethylquinolin-4-yl)amine	Ki	132.0 [1], 132.13 [2]
	N-[4-[(3S)-3,4-Dimethylpiperazin-1-yl]phenyl]-2,3,7,8-tetramethylquinolin-4-amine	Ki	83.95 [1], 84.0 [2]
	N-[4-[(3R)-3,4-Dimethylpiperazin-1-yl]phenyl]-2,3,7-trimethylquinolin-4-amine	Ki	8.3 [1]
	N-[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-2,3,8-trimethylquinolin-4-amine	Ki	6.9 [1]
	N-[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-2,3,5,8-tetramethylquinolin-4-amine	Ki	389.94 [1], 390.0 [2]
	(5-Chloro-2,3-dimethylquinolin-4-yl)-[4-(3,4-dimethylpiperazin-1-yl)phenyl]amine	Ki	134.9 [1], 135.0 [2]
	2,3,8-Trimethyl-N-[4-(3-methyl-1,3-diazinan-1-yl)phenyl]quinolin-4-amine	Ki	770.0 [1], 5000.35 [2]
	4-N-(2,3-Dimethylquinolin-4-yl)-1-N-(2-pyrrolidin-1-ylethyl)benzene-1,4-diamine	Ki	100.0 [1]
	[4-[4-[(3R)-3,4-Dimethylpiperazin-1-yl]anilino]-3-methylquinolin-2-yl]methanol	Ki	8.99 [1], 9.0 [2]
	(R)-{4-[4-(3,4-Dimethylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol	Ki	9.2 [1]
	(3-Benzyl-2-methylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)-phenyl]amine	Ki	34.99 [1], 35.0 [2]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(3-methylquinolin-4-yl)amine	Ki	8.49 [1], 8.5 [2]
	N-[4-[(3R)-3,4-Dimethylpiperazin-1-yl]phenyl]-2,3,7,8-tetramethylquinolin-4-amine	Ki	7.69 [1], 7.7 [2]
	N-[4-[(3S)-3,4-Dimethylpiperazin-1-yl]phenyl]-2,3,7-trimethylquinolin-4-amine	Ki	76.0 [1], 76.03 [2]
	[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-(2,3,5-trimethylquinolin-4-yl)amine	Ki	87.0 [1], 87.1 [2]
	N-[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-6-fluoro-2,3-dimethylquinolin-4-amine	Ki	16.0 [1]
	1-N-[2-(Diethylamino)ethyl]-4-N-(3-ethyl-2,8-dimethylquinolin-4-yl)benzene-1,4-diamine	Ki	82.0 [1], 82.04 [2]
	(3-Ethyl-2,8-dimethylquinolin-4-yl)-[4-(4-methyl-[1,4]diazepan-1-yl)phenyl]amine	Ki	8.49 [1], 8.5 [2]
	[2-Methyl-4-[4-(3,3,4-trimethylpiperazin-1-yl)anilino]quinolin-3-yl]methanol	Ki	3.8 [1]
	1-[4-[4-(3,4-Dimethylpiperazin-1-yl)anilino]-2-methylquinolin-3-yl]ethanol	Ki	4.9 [1]
	(R)-{4-[4-(3-Methylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol	Ki	205.0 [1], 205.12 [2]
	[4-[4-[(3R)-3,4-Dimethylpiperazin-1-yl]anilino]-6-fluoroquinolin-3-yl]methanol	Ki	38.0 [1], 38.02 [2]
	(3,5-Dimethyl-pyridin-4-yl)-[4-(4-methylpiperazin-1-yl)phenyl]amine	Ki	769.13 [1], 5000.0 [2]
	N-[4-(3,4-Dimethylpiperazin-1-yl)phenyl]-3-ethyl-2-methyl-5,6,7,8-tetrahydroquinolin-4-amine	Ki	109.9 [1], 110.0 [2]
	(3R,3As)-3-[[4-[(E)-3-(4-fluorophenyl)-2-methylprop-2-enyl]piperazin-1-yl]methyl]-7,8-dimethoxy-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	0.7 [1]
	(R)-3-Nitrobiphenyline	Ki	257.04 [1], 363.08 [2]
	2-[(1S)-1-[2-(3-Nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	537.03 [1]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(Z)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	9.5 [1]
	2-[1-(2-Cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	79.43 [1]
	2-[(1S)-1-(2-Cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	63.1 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-2c adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/alpha-2c-adrenergic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Alpha-2c adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-2c-adrenergic-receptor-inhibitors-ic50-ki.
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