Alpha-2b adrenergic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Yohimbine	Ki	4.6 [1]
	Idazoxan	IC50	19.5 [1]
	Idazoxan	Ki	22.91 [1], 100.0 [2]
	Terazosin	Ki	26.0 [1], 30.9 [2], 195.0 [3], 418.0 [4]
	2-[1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	338.84 [1]
	Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	794.33 [1], 800.0 [2], 1088.0 [3], 1170.0 [4]
	2-[1-(2-Biphenylyloxy)ethyl]-2-imidazoline	Ki	501.19 [1]
	Clonidine	Ki	6.17 [1], 31.62 [2], 38.0 [3]
	Prazosin	Ki	13.0 [1], 133.0 [2], 365.0 [3]
	Phentolamine	Ki	7.6 [1], 8.23 [2], 48.0 [3]
	3-[2-[1-(4,5-Dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol	Ki	354.81 [1]
	2-[1-[2-(3-Nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	660.69 [1]
	2-[(1S)-1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	398.11 [1]
	2-[(1R)-1-(2-Prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	562.34 [1]
	2-[1-[2-(Cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	407.38 [1]
	Clozapine	Ki	11.0 [1], 100.0 [2]
	Risperidone	Ki	12.0 [1], 1000.0 [2]
	Olanzapine	Ki	100.0 [1], 192.0 [2]
	Quetiapine	Ki	45.8 [1], 1000.0 [2]
	Brimonidine	Ki	34.67 [1], 478.0 [2]
	Oxymetazoline	Ki	581.0 [1], 5370.32 [2]
	Rilmenidine	Ki	42.66 [1], 70.79 [2]
	Clemastine	Ki	142.0 [1], 478.63 [2]
	Cirazoline	Ki	524.81 [1]
	Niguldipine	Ki	420.0 [1], 5000.0 [2]
	Unii-22xbk6DY1E	Ki	142.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	1H-Imidazole, 4,5-dihydro-2-(1-phenoxyethyl)-	Ki	165.96 [1]
	2-(1-Benzofuran-6-yl)-N-[[(1R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl]-N-methylethanamine	Ki	11.0 [1]
	2-[(1S)-1-(2-Phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	588.84 [1]
	4-(5-Fluoro-2-indanylmethyl)-2-imidazoline	Ki	23.0 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	912.0 [1], 933.25 [2]
	2-[(1R)-1-(2-Phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	1258.93 [1]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	14.0 [1], 42.0 [2]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-2-methyl-3-phenylprop-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	3.0 [1]
	(3R,3As)-7,8-dimethoxy-3-[[4-[(E)-3-phenylbut-2-enyl]piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	14.0 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	275.0 [1], 416.87 [2]
	1-Benzyl-4-chroman-2-ylmethyl-piperazine	Ki	72.8 [1], 180.0 [2]
	2-[1-[2-(3-Fluorophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	269.15 [1]
	3-[2-[1-(4,5-Dihydro-1H-imidazol-2-yl)ethoxy]phenyl]pyridine	Ki	933.25 [1]
	2-[1-(2-Thiophen-3-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	416.87 [1]
	(R)-3-Nitrobiphenyline	Ki	741.31 [1]
	2-[(1S)-1-[2-(3-Nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	1584.89 [1]
	(3R,3As)-7,8-dimethoxy-3-[[4-(naphthalen-2-ylmethyl)piperazin-1-yl]methyl]-3a,4-dihydro-3H-chromeno[4,3-c][1,2]oxazole	Ki	14.0 [1]
	2-[1-(2-Cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	309.03 [1]
	2-[(1S)-1-(2-Cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	263.03 [1]
	2-[(1R)-1-(2-Cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	562.34 [1]
	2-(1-(2-Bromophenoxy)ethyl)-4,5-dihydro-1H-imidazole	Ki	354.81 [1]
	2-[1-(2-Cyclopropyloxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole	Ki	1047.13 [1]
	2-[(1R)-1-[2-(Cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	338.84 [1]
	2-[(1S)-1-[2-(Cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole	Ki	407.38 [1]
	5-O-[3-(4,4-Diphenylpiperidin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	570.0 [1], 758.0 [2]
	N-[2-[4-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-1,4-diazepan-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide	Ki	14.3 [1], 31.3 [2]
	1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-(2-methoxyphenyl)piperazine	Ki	17.0 [1], 194.0 [2]
	N-[2-[4-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide	Ki	49.0 [1], 132.0 [2]
	2-(3-Cyanophenoxy)-N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]pyridine-3-carboxamide	Ki	27.5 [1], 36.0 [2]
	2-(Tert-butylamino)-N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]pyridine-3-carboxamide	Ki	28.0 [1], 103.0 [2]
	2-Butoxy-N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]pyridine-3-carboxamide	Ki	10.5 [1], 13.3 [2]
	6-Butoxy-N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]pyridine-2-carboxamide	Ki	10.9 [1], 14.1 [2]
	1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-4-[2-[(2-phenoxypyridin-3-yl)methoxy]ethyl]-1,4-diazepane	Ki	69.5 [1], 132.0 [2]
	5-[[4-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]methyl]-3-(2-phenoxypyridin-3-yl)-1,2,4-oxadiazole	Ki	5.2 [1], 15.3 [2]
	Epinephrine	Ki	397.0 [1]
	Tamoxifen	Ki	1606.0 [1]
	Chlorpromazine	Ki	12.0 [1]
	Haloperidol	Ki	618.0 [1]
	Fluoxetine	Ki	698.0 [1]
	Chloroquine	Ki	31622.78 [1]
	Ticlopidine	Ki	139.0 [1]
	Amiodarone	Ki	5886.0 [1]
	Celecoxib	Ki	692.0 [1]
	Amitriptyline	Ki	3.69 [1]
	Ketoconazole	Ki	8239.0 [1]
	Diethylstilbestrol	Ki	5340.0 [1]
	Bromocriptine	Ki	16.0 [1]
	Dobutamine	Ki	1354.0 [1]
	Mifepristone	Ki	12082.0 [1]
	Sertraline	Ki	82.8 [1]
	Rauwolscine	Ki	4.7 [1]
	Corynanthine	Ki	455.0 [1]
	Raloxifene	Ki	1688.0 [1]
	Clomiphene	Ki	721.0 [1]
	Hydroxychloroquine	Ki	72443.6 [1]
	Carvedilol	Ki	43.0 [1]
	Aripiprazole	Ki	1000.0 [1]
	Clomipramine	Ki	46.0 [1]
	Candesartan	Ki	1754.4 [1]
	Quinacrine	Ki	833.0 [1]
	Disulfiram	Ki	1469.0 [1]
	Promethazine	Ki	24.0 [1]
	Isotretinoin	Ki	3019.0 [1]
	Mianserin	Ki	24.0 [1]
	Selegiline	Ki	172.0 [1]
	Danazol	Ki	10574.0 [1]
	Miconazole	Ki	1642.0 [1]
	Methysergide	Ki	2175.0 [1]
	Clotrimazole	Ki	3725.0 [1]
	Mirtazapine	IC50	223.87 [1]
	Droperidol	Ki	101.0 [1]
	Thioridazine	Ki	174.0 [1]
	Fluphenazine	Ki	13.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-2b adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 30 Mar. 2025, https://www.aatbio.com/data-sets/alpha-2b-adrenergic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 30). Quest Database™ Alpha-2b adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-2b-adrenergic-receptor-inhibitors-ic50-ki.
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