Alpha-1d adrenergic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Prazosin	IC50	0.88 [1]
	Tamsulosin	IC50	1.4 [1]
	Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	1047.0 [1]
	Cyclazosin	Ki	0.17 [1], 3.24 [2], 31.62 [3]
	3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	0.36 [1], 2.75e+18 [2]
	N-((1r,4r)-4-(4-(2-Cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	2.0 [1], 34.0 [2]
	N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	0.77 [1], 1.7 [2], 40.0 [3]
	3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	2.2 [1], 23.0 [2]
	N-((1r,4r)-4-(4-(2-(2-Fluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	5.5 [1], 8.8 [2], 49.0 [3]
	N-[4-[4-[2-(2,2-Difluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	4.1 [1], 8.6 [2], 86.0 [3]
	3,4-Dimethoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	0.68 [1], 1.0 [2], 24.0 [3]
	Phentolamine	Ki	7.6 [1], 11.0 [2], 19.4 [3]
	Yohimbine	Ki	1.6 [1], 289.0 [2], 498.0 [3]
	Silodosin	IC50	6.3 [1], 27.3 [2]
	Silodosin	Ki	2.0 [1]
	Naftopidil	IC50	55.2 [1]
	Naftopidil	Ki	1.2 [1]
	8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride	Ki	1.05 [1], 1.29 [2], 6.31 [3]
	7-Chloro-2-ethenyl-3,4,5,6-tetrahydro-4-methylthieno(4,3,2-ef)(3)benzazepine	Ki	1.6 [1], 3.16 [2]
	Methyl 1-[3-[[5-carbamoyl-4-(3,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	340.0 [1], 350.0 [2]
	(4S,5S)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5-methyl-2-oxo-1,3-oxazolidine-3-carboxamide	Ki	122.0 [1], 133.0 [2]
	8-[(2R)-1-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dione	Ki	1.3 [1], 1.6 [2]
	N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	0.51 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	616.0 [1], 616.6 [2], 758.58 [3]
	N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethanamine;oxalic acid	Ki	11.48 [1], 11.75 [2]
	Rauwolscine	Ki	3.5 [1], 1320.0 [2]
	Brimonidine	Ki	846.0 [1], 933.25 [2]
	Oxymetazoline	Ki	1348.96 [1], 1398.0 [2]
	Alfuzosin	Ki	3.16 [1], 3.6 [2]
	Indoramin	Ki	110.0 [1], 158.49 [2]
	5-Methylurapidil	Ki	10.0 [1], 21.0 [2]
	Niguldipine	Ki	100.0 [1], 191.0 [2]
	Dexniguldipine	Ki	100.0 [1], 170.0 [2]
	Upidosin	Ki	1.5 [1], 2.51 [2]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	CID 9872515	Ki	63.1 [1], 100.0 [2]
	2-(2-Biphenylyloxymethyl)-2-imidazoline	IC50	323.59 [1], 549.54 [2]
	N-[2-(2,6-Dimethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine	Ki	0.07 [1]
	Methyl 4-(3,4-difluorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	140.0 [1]
	2-(2,6-Dimethoxyphenoxy)-N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine	Ki	56.23 [1], 66.07 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine	Ki	1.15 [1], 1.38 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine	Ki	3.24 [1], 3.63 [2]
	5-N-[4-(4,4-Diphenylpiperidin-1-yl)butyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	398.0 [1], 398.11 [2]
	N-[[(3R)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	10.47 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	346.0 [1], 602.56 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione	Ki	1.26 [1]
	Methyl 1-[3-[[5-carbamoyl-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	340.0 [1], 440.0 [2]
	Methyl 4-(3,4-difluorophenyl)-3-[5-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)pentyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	150.0 [1]
	Methyl 5-[4-(4,4-diphenylpiperidin-1-yl)butylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	144.54 [1], 331.13 [2]
	3-[2-[4-(4-Propan-2-ylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	35.48 [1], 2.82e+16 [2]
	3-[2-[4-(4-Butan-2-ylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	60.26 [1], 1.66e+16 [2]
	3-[2-[4-(4-Butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	245.47 [1], 4073800000000000.0 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Ki	0.41 [1], 2.45e+18 [2]
	3-[2-[4-(4-Tert-butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	19.95 [1], 5.01e+16 [2]
	5-Chloro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	0.75 [1], 11.0 [2]
	1-[3-(Di-p-tolylacetylamino)propyl]-4-phenylpiperidine-4-carbonitrile	Ki	1400.0 [1]
	N-[(6,6-Diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-methoxyphenoxy)ethanamine	Ki	1.15 [1]
	1-(1,4-Dioxaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine	Ki	1000.0 [1]
	1-[3-(Di-p-tolylacetylamino)propyl]-4-phenylpiperidine-4-carboxylic acid methyl ester	Ki	960.0 [1], 975.0 [2]
	1-[3-(4-Methylphenylacetylamino)propyl]-4-phenyl-4-piperidinecarboxylic acid methyl ester	Ki	3400.0 [1]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-[1]benzothiolo[3,2-d]pyrimidin-4-one	Ki	0.4 [1]
	N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-4-(methylsulfonyl)benzenesulfonamide	Ki	3.4 [1], 22.0 [2]
	2-Methoxy-5-methyl-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	7.0 [1], 31.0 [2]
	5-Fluoro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	5.0 [1], 66.0 [2]
	2,4-Dichloro-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	0.64 [1], 8.6 [2]
	[(4Ar,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone	Ki	0.17 [1], 3.89 [2]
	N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid	Ki	9.33 [1]
	N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2-methoxynaphthalen-1-yl)oxyethanamine;hydrochloride	Ki	6.61 [1]
	1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-4-phenylpiperidine-2,6-dione	Ki	2.0 [1], 15.85 [2]
	5-Methyl-1,5-diazapentacyclo[10.8.1.02,7.08,21.013,18]henicosa-2(7),8(21),9,11,13,15,17-heptaene	Ki	293.0 [1], 295.12 [2]
	[(4As,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone	Ki	0.06 [1], 3.24 [2]
	5-O-[3-(4,4-Diphenylpiperidin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	210.0 [1], 302.0 [2]
	N,N'-Bis(8-methylquinolin-4-yl)ethane-1,2-diamine	Ki	478.63 [1], 479.0 [2]
	Methyl 4-(3,4-difluorophenyl)-3-[5-(4,4-diphenylpiperidin-1-yl)pentyl]-2,6-dimethyl-4H-pyrimidine-5-carboxylate	Ki	110.0 [1], 180.0 [2]
	3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	0.35 [1], 8.3 [2]
	3,4-Difluoro-N-((1r,4r)-4-(4-(2-isopropoxyphenyl)piperidin-1-yl)cyclohexyl)benzenesulfonamide	Ki	7.3 [1], 87.0 [2]
	5-Chloro-N-[4-[4-(2-cyclopropyloxyphenyl)piperidin-1-yl]cyclohexyl]-2-methoxybenzenesulfonamide	Ki	2.6 [1], 47.0 [2]
	5-Chloro-N-((1r,4r)-4-(4-(2-cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-2-fluorobenzenesulfonamide	Ki	2.1 [1], 32.0 [2]
	N-[4-[4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide	Ki	3.0 [1], 26.0 [2]
	5-Chloro-2-methoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	1.6 [1], 36.0 [2]
	5-Chloro-2-fluoro-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	0.98 [1], 44.0 [2]
	3-(Difluoromethoxy)-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	5.9 [1], 70.0 [2]
	N-[4-[4-(4-Fluoro-2-propan-2-yloxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	12.0 [1], 60.0 [2]
	N-[4-[4-(5-Fluoro-2-propan-2-yloxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	1.6 [1], 53.0 [2]
	N,N'-Bis(6-methylquinolin-4-yl)ethane-1,2-diamine	Ki	489.78 [1], 490.0 [2]
	N,N'-Bis(7-methylquinolin-4-yl)ethane-1,2-diamine	Ki	204.0 [1], 204.17 [2]
	N,N'-Bis(7-methoxyquinolin-4-yl)ethane-1,2-diamine	Ki	213.8 [1], 214.0 [2]
	N,N'-Bis(6-methylquinolin-4-yl)heptane-1,7-diamine	Ki	478.63 [1], 479.0 [2]
	N,N'-Bis(6-methoxyquinolin-4-yl)heptane-1,7-diamine	Ki	371.54 [1], 372.0 [2]
	N,N'-Bis(7-methylquinolin-4-yl)heptane-1,7-diamine	Ki	489.78 [1], 490.0 [2]
	N,N'-Bis(7-methoxyquinolin-4-yl)heptane-1,7-diamine	Ki	229.0 [1], 229.09 [2]
	N,N'-Bis(8-methoxyquinolin-4-yl)heptane-1,7-diamine	Ki	758.58 [1], 759.0 [2]
	1,7-Heptanediamine, N,N'-di-4-quinolinyl-	Ki	309.0 [1], 309.03 [2]
	1,2-Ethanediamine, N,N-di-4-quinolinyl-	Ki	331.0 [1], 331.13 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 94 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-1d adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/alpha-1d-adrenergic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Alpha-1d adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-1d-adrenergic-receptor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan