Alpha-1b adrenergic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tamsulosin	IC50	4.8 [1]
	Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	269.0 [1]
	Doxazosin	Ki	0.63 [1], 0.74 [2], 0.81 [3], 1.0 [4]
	3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	1.82 [1]
	N-((1r,4r)-4-(4-(2-Cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	133.0 [1], 141.0 [2]
	N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	144.0 [1], 148.0 [2], 151.0 [3]
	3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	123.0 [1], 368.0 [2]
	N-((1r,4r)-4-(4-(2-(2-Fluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	354.0 [1], 401.0 [2], 4403.0 [3]
	N-[4-[4-[2-(2,2-Difluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	278.0 [1], 300.0 [2], 681.0 [3]
	3,4-Dimethoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	106.0 [1], 109.0 [2], 126.0 [3]
	Yohimbine	Ki	1.1 [1], 7.2 [2], 966.0 [3]
	Rauwolscine	Ki	0.6 [1], 4.6 [2], 2270.0 [3]
	Alfuzosin	Ki	2.8 [1], 10.0 [2], 12.0 [3]
	Azelastine	Ki	50.12 [1]
	Silodosin	IC50	116.0 [1], 541.4 [2]
	Silodosin	Ki	19.95 [1]
	Naftopidil	IC50	634.0 [1]
	Naftopidil	Ki	19.95 [1]
	Indoramin	Ki	25.0 [1], 29.0 [2], 39.81 [3]
	8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride	Ki	50.12 [1], 630.96 [2], 707.95 [3]
	5-Methylurapidil	Ki	39.81 [1], 92.0 [2], 535.0 [3]
	Niguldipine	Ki	25.01 [1], 55.0 [2], 85.0 [3]
	7-Chloro-2-ethenyl-3,4,5,6-tetrahydro-4-methylthieno(4,3,2-ef)(3)benzazepine	Ki	19.95 [1], 23.0 [2]
	Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate	IC50	8.8 [1], 5800.0 [2]
	Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate	Ki	2.0 [1]
	2-[[(2R)-1-[4-[4-[3-(Azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one	Ki	31.62 [1]
	Methyl 1-[3-[[5-carbamoyl-4-(3,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	250.0 [1], 260.0 [2]
	(4S,5S)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5-methyl-2-oxo-1,3-oxazolidine-3-carboxamide	Ki	119.0 [1], 121.0 [2]
	8-[(2R)-1-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dione	Ki	165.0 [1], 191.0 [2]
	N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	5.75 [1]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	416.0 [1], 416.87 [2], 489.78 [3]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	330.0 [1], 331.13 [2], 407.0 [3]
	N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethanamine;oxalic acid	Ki	63.1 [1]
	[(4As,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone	Ki	0.07 [1], 0.13 [2], 0.69 [3]
	Phentolamine	Ki	4.8 [1], 47.4 [2]
	Cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-	Ki	66.07 [1], 322.0 [2]
	Dexniguldipine	Ki	54.95 [1], 56.0 [2]
	Abanoquil	Ki	0.08 [1], 0.11 [2]
	Upidosin	Ki	3.9 [1], 31.62 [2]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	CID 9872515	Ki	79.43 [1]
	CID 9891980	IC50	1.2 [1]
	CID 9891980	Ki	0.45 [1]
	2-(2-Biphenylyloxymethyl)-2-imidazoline	IC50	741.31 [1], 2398.83 [2]
	N-[2-(2,6-Dimethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine	Ki	0.54 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	1995.26 [1]
	Methyl 4-(3,4-difluorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	45.0 [1]
	2-(2,6-Dimethoxyphenoxy)-N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine	Ki	194.98 [1], 323.59 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine	Ki	21.88 [1], 56.23 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine	Ki	52.48 [1], 120.23 [2]
	5-N-[4-(4,4-Diphenylpiperidin-1-yl)butyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	331.13 [1], 367.0 [2]
	N-[[(3R)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	72.44 [1]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione	Ki	8.91 [1]
	Methyl 1-[3-[[5-carbamoyl-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	220.0 [1], 340.0 [2]
	Methyl 4-(3,4-difluorophenyl)-3-[5-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)pentyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	140.0 [1]
	Methyl 1-[3-[[5-carbamoyl-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	2740.0 [1], 3700.0 [2]
	Methyl 5-[4-(4,4-diphenylpiperidin-1-yl)butylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	64.57 [1], 134.9 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Ki	20.89 [1]
	Methyl 5-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	700.0 [1]
	4-[(4-Chlorophenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one	Ki	10.0 [1], 12.59 [2]
	5-Chloro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	78.0 [1], 250.0 [2]
	1-[3-(Di-p-tolylacetylamino)propyl]-4-phenylpiperidine-4-carbonitrile	Ki	2000.0 [1]
	N-[(6,6-Diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-methoxyphenoxy)ethanamine	Ki	56.23 [1]
	1-(1,4-Dioxaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine	Ki	125.89 [1]
	1-[3-(Di-p-tolylacetylamino)propyl]-4-phenylpiperidine-4-carboxylic acid methyl ester	Ki	170.0 [1], 450.0 [2]
	1-[3-(4-Methylphenylacetylamino)propyl]-4-phenyl-4-piperidinecarboxylic acid methyl ester	Ki	3000.0 [1]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-[1]benzothiolo[3,2-d]pyrimidin-4-one	Ki	17.38 [1]
	N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-4-(methylsulfonyl)benzenesulfonamide	Ki	195.0 [1], 392.0 [2]
	2-Methoxy-5-methyl-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	162.0 [1], 218.0 [2]
	5-Fluoro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	162.0 [1], 714.0 [2]
	2,4-Dichloro-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	177.0 [1], 596.0 [2]
	[(4Ar,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone	Ki	0.42 [1], 1.41 [2]
	N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid	Ki	45.71 [1], 46.77 [2]
	N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2-methoxynaphthalen-1-yl)oxyethanamine;hydrochloride	Ki	15.85 [1]
	1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-4-phenylpiperidine-2,6-dione	Ki	3.98 [1], 23.99 [2]
	5-[(3,4-Dimethoxyphenyl)methyl]-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	2766.0 [1]
	8-{2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione	Ki	62.62 [1], 67.0 [2]
	8-{2-[4-(2,5-Difluorophenyl)piperazin-1-yl]ethyl)-8-azaspiro[4.5]decane-7,9-dione	Ki	5.88 [1], 54.0 [2]
	5-O-[3-(4,4-Diphenylpiperidin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	50.0 [1], 85.0 [2]
	N,N'-Bis(8-methylquinolin-4-yl)ethane-1,2-diamine	Ki	39.81 [1], 40.0 [2]
	4-Amino-6,7-dimethoxy-2-[(3S)-3-(t-butylcarbamoyl)-1-piperazinyl]quinazoline	IC50	31.0 [1]
	4-Amino-6,7-dimethoxy-2-[(3S)-3-(t-butylcarbamoyl)-1-piperazinyl]quinazoline	Ki	25.0 [1]
	3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	39.0 [1], 86.0 [2]
	3,4-Difluoro-N-((1r,4r)-4-(4-(2-isopropoxyphenyl)piperidin-1-yl)cyclohexyl)benzenesulfonamide	Ki	470.0 [1], 1385.0 [2]
	5-Chloro-N-[4-[4-(2-cyclopropyloxyphenyl)piperidin-1-yl]cyclohexyl]-2-methoxybenzenesulfonamide	Ki	82.0 [1], 305.0 [2]
	5-Chloro-N-((1r,4r)-4-(4-(2-cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-2-fluorobenzenesulfonamide	Ki	107.0 [1], 337.0 [2]
	N-[4-[4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide	Ki	91.0 [1], 92.0 [2]
	5-Chloro-2-methoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	216.0 [1], 703.0 [2]
	5-Chloro-2-fluoro-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	181.0 [1], 787.0 [2]
	3-(Difluoromethoxy)-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	261.0 [1], 355.0 [2]
	N-[4-[4-(4-Fluoro-2-propan-2-yloxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	639.0 [1], 690.0 [2]
	N-[4-[4-(5-Fluoro-2-propan-2-yloxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	299.0 [1], 1487.0 [2]
	N,N'-Bis(6-methylquinolin-4-yl)ethane-1,2-diamine	Ki	19.0 [1], 19.05 [2]
	N,N'-Bis(7-methylquinolin-4-yl)ethane-1,2-diamine	Ki	47.86 [1], 48.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 94 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-1b adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/alpha-1b-adrenergic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Alpha-1b adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-1b-adrenergic-receptor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan