Alpha-1a adrenergic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2-(2',6'-Dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane	IC50	1.0 [1]
	Tamsulosin	IC50	2.2 [1]
	Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	1.3 [1]
	Risperidone	IC50	10.0 [1], 10.9 [2]
	Risperidone	Ki	2.3 [1], 2.8 [2], 10.0 [3]
	Aripiprazole	IC50	170.0 [1]
	Aripiprazole	Ki	26.0 [1], 100.0 [2]
	Doxazosin	Ki	0.54 [1], 0.78 [2], 2.6 [3], 3.16 [4]
	Naftopidil	IC50	555.0 [1]
	Naftopidil	Ki	3.7 [1], 3.71 [2], 5.88 [3]
	3-[1-[4-(5-Chloro-1,1,3-trioxo-1,2-benzothiazol-2-yl)butyl]piperidin-4-yl]-1,3-benzoxazol-2-one	Ki	0.08 [1], 0.17 [2], 0.24 [3], 74.0 [4], 90.0 [5]
	Silodosin	IC50	1.8 [1], 1.9 [2]
	Silodosin	Ki	0.04 [1]
	Cyclazosin	Ki	5.5 [1], 12.3 [2], 25.12 [3]
	3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Ki	0.27 [1], 0.29 [2], 3.72e+18 [3]
	(4S,5S)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5-methyl-2-oxo-1,3-oxazolidine-3-carboxamide	Ki	0.17 [1], 0.23 [2]
	8-[(2R)-1-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dione	Ki	290.0 [1], 294.0 [2], 14000.0 [3], 14900.0 [4]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	3.1 [1], 3.16 [2], 4.47 [3]
	5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	1.3 [1], 1.86 [2], 1.87 [3]
	N-((1r,4r)-4-(4-(2-Cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	0.91 [1], 11.0 [2]
	N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	1.8 [1], 2.2 [2], 28.0 [3]
	3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide	Ki	1.8 [1], 21.0 [2]
	N-((1r,4r)-4-(4-(2-(2-Fluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide	Ki	8.5 [1], 11.0 [2], 69.0 [3]
	N-[4-[4-[2-(2,2-Difluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide	Ki	12.0 [1], 31.0 [2]
	3,4-Dimethoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	1.6 [1], 2.0 [2], 23.0 [3]
	Clozapine	Ki	10.0 [1], 19.0 [2]
	Olanzapine	Ki	60.0 [1], 1000.0 [2]
	Phentolamine	Ki	0.6 [1], 4.12 [2], 12.0 [3]
	Azelastine	Ki	50.12 [1]
	8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride	Ki	42.66 [1], 251.19 [2], 380.19 [3]
	Niguldipine	Ki	0.16 [1], 1.8 [2]
	Upidosin	Ki	0.34 [1], 1.0 [2]
	7-Chloro-2-ethenyl-3,4,5,6-tetrahydro-4-methylthieno(4,3,2-ef)(3)benzazepine	Ki	25.12 [1], 36.0 [2]
	Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate	IC50	590.0 [1]
	Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate	Ki	420.0 [1]
	CID 9872515	Ki	1.0 [1], 1.26 [2], 1.3 [3]
	2-[[(2R)-1-[4-[4-[3-(Azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one	Ki	39.81 [1]
	N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	0.41 [1]
	N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine	IC50	537.03 [1]
	Methyl 4-(3,4-difluorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	0.1 [1], 1.0 [2]
	5-N-[4-(4,4-Diphenylpiperidin-1-yl)butyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	1.86 [1], 1.87 [2], 1.9 [3]
	Methyl 5-[4-(4,4-diphenylpiperidin-1-yl)butylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	5.89 [1], 14.79 [2]
	Methyl 5-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	3.55 [1], 3.58 [2], 3.6 [3]
	1-(1,4-Dioxaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine	Ki	91.2 [1]
	N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethanamine;oxalic acid	Ki	37.15 [1]
	Methyl 1-[3-[[5-carbamoyl-6-ethyl-4-(4-nitrophenyl)-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	0.19 [1], 0.5 [2], 1.9 [3]
	Clonidine	Ki	512.86 [1], 977.24 [2]
	Quetiapine	Ki	20.0 [1], 100.0 [2]
	Corynanthine	Ki	29.0 [1], 142.0 [2]
	Mianserin	IC50	407.38 [1]
	Cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-	Ki	18.62 [1], 20.0 [2]
	Alfuzosin	Ki	8.2 [1], 10.0 [2]
	Rilmenidine	Ki	6025.6 [1], 8912.51 [2]
	1-(2-Methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine	Ki	0.26 [1], 2.0 [2]
	Indoramin	Ki	3.7 [1], 3.98 [2]
	5-Methylurapidil	Ki	0.63 [1], 2.3 [2]
	Dexniguldipine	Ki	0.16 [1], 4.7 [2]
	1-(5-Chloro-1H-indol-3-yl)-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-2-methylpropan-2-amine	Ki	0.6 [1], 0.63 [2]
	5-Methyl-3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-1H-pyrimidine-2,4-dione	Ki	0.25 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	Methyl (4R)-5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate	Ki	0.18 [1]
	5-[2-[(3Ar,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-thia-3,5,13-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),10,12-tetraene-4,6-dione	Ki	0.22 [1]
	2-(2-Biphenylyloxymethyl)-2-imidazoline	IC50	27.54 [1], 66.07 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-5-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione	Ki	2.6 [1], 2.63 [2]
	N-[2-(2,6-Dimethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine	Ki	0.47 [1]
	2-Bromo-7-chloro-11-methyl-3-oxa-11-azatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraene	Ki	3300.0 [1]
	2-(2-Oxopiperidin-1-yl)-N-[3-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]propyl]acetamide	Ki	0.65 [1], 0.66 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-5-(3-methylphenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione	Ki	4.17 [1], 4.2 [2]
	2,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-3,10-diol	Ki	616.0 [1], 630.0 [2]
	2-(2,6-Dimethoxyphenoxy)-N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine	Ki	165.96 [1], 338.84 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine	Ki	16.6 [1], 27.54 [2]
	N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine	Ki	128.82 [1], 169.82 [2]
	(4S)-2-(2-Aminoethoxymethyl)-3-N-[3-(4,4-diphenylpiperidin-1-yl)propyl]-6-ethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide	Ki	0.4 [1], 0.65 [2]
	N-[[(3R)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride	Ki	11.22 [1]
	JTH-601 free base	Ki	0.4 [1]
	Unii-M7ias8PR23	Ki	8.7 [1], 9.3 [2]
	2-(2-Oxoazepan-1-yl)-N-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]acetamide	Ki	18.0 [1], 22.0 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione	Ki	3.31 [1]
	Methyl 1-[3-[[2,6-dimethyl-5-(methylcarbamoyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	3.98 [1], 607.0 [2]
	(4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-6-(methoxymethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Ki	0.24 [1]
	Methyl 1-[3-[[5-carbamoyl-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	0.2 [1]
	1-(17-Chloro-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl)-N,N-dimethylmethanamine	IC50	14.45 [1]
	(4R)-4-(3,4-Difluorophenyl)-6-(methoxymethyl)-2-oxo-N-[3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-3,4-dihydro-1H-pyrimidine-5-carboxamide	Ki	0.45 [1]
	(4R)-N-[3-[4-(2-Cyanophenyl)piperidin-1-yl]propyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Ki	0.13 [1]
	(4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-1,3,6-trimethyl-2-oxo-4H-pyrimidine-5-carboxamide	Ki	0.14 [1], 0.18 [2]
	(4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Ki	0.17 [1]
	Methyl (4R)-4-(3,4-difluorophenyl)-5-[3-[4-(4-fluorophenyl)piperidin-1-yl]propylcarbamoyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-3-carboxylate	Ki	0.75 [1]
	Methyl 4-(3,4-difluorophenyl)-3-[5-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)pentyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate	Ki	0.1 [1]
	(4R)-N-[3-[4-(2-Cyano-4-fluorophenyl)piperidin-1-yl]propyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Ki	0.07 [1]
	(4R)-3-Acetyl-4-(3,4-difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-5-carboxamide	Ki	2.2 [1]
	Methyl 1-[3-[[5-carbamoyl-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	0.84 [1], 2.4 [2]
	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Ki	3.02 [1], 3.31e+17 [2]
	4-[(4-Chlorophenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one	Ki	25.12 [1], 31.62 [2]
	5-Chloro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide	Ki	1.0 [1], 3.8 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 94 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Alpha-1a adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/alpha-1a-adrenergic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Alpha-1a adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alpha-1a-adrenergic-receptor-inhibitors-ic50-ki.
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