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Aldehyde reductase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SorbinilIC504600.0 [1], 5400.0 [2]
TolrestatIC50720.0 [1], 1940.0 [2]
EpalrestatIC502600.0 [1]
ZopolrestatIC502700.0 [1], 38600.0 [2]
FidarestatIC501200.0 [1]
Valproic acidIC5050100.0 [1]
ZenarestatIC509900.0 [1]
LidorestatIC5027000.0 [1]
Idd594IC5033000.0 [1]
MinalrestatIC506.7 [1]
(2Z)-7-Hydroxy-2-[(4-methoxyphenyl)imino]-N-(pyridin-2-yl)-2H-chromene-3-carboxamideIC5025000.0 [1]
(2Z)-2-[(2,5-Dimethoxyphenyl)imino]-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamideIC5040000.0 [1]
2-Benzyl-9-(carboxymethyl)-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indole-6-carboxylic acidIC5053000.0 [1]
2-{5-Bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC504700.0 [1]
2-(5-Chloro-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-1H-indol-1-yl)acetic acidIC504900.0 [1]
2-{3-[(4-Fluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5011000.0 [1]
2-{3-[(7-Fluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5018000.0 [1]
2-{3-[(4,6-Difluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC505100.0 [1]
2-{3-[2-(4,5,7-Trifluoro-1,3-benzothiazol-2-yl)ethyl]-1H-indol-1-yl}acetic acidIC5011000.0 [1]
2-{3-[(5,6-Difluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5013000.0 [1]
(2Z)-2-[(3,4-Dimethoxyphenyl)imino]-7-hydroxy-N-(6-methylpyridin-2-yl)-2H-chromene-3-carboxamideIC5040000.0 [1]
(2Z)-2-[(2,4-Dimethoxyphenyl)imino]-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamideIC5038000.0 [1]
N-[3-(4-Fluorophenyl)propyl]-7-hydroxy-2-oxochromene-3-carboxamideIC501700.0 [1]
7-Hydroxy-N-[3-(4-hydroxyphenyl)propyl]-2-oxochromene-3-carboxamideIC501500.0 [1]
2-(2-Benzyl-5,7-difluoro-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC504700.0 [1]
2-Benzyl-1,2,3,4-tetrahydro-1-thioxo-9H-pyrido[3,4-b]indole-9-acetic acidIC509500.0 [1]
2-(2-Benzyl-6-fluoro-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5019000.0 [1]
2-[2-[(4-Bromophenyl)methyl]-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl]acetic acidIC5014000.0 [1]
2-(2-Benzyl-6-methoxy-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5012000.0 [1]
2-(2-Benzyl-6-iodo-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5011000.0 [1]
2-(2-Benzyl-6-propan-2-yl-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5016000.0 [1]
2-(2-Benzyl-6-bromo-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5011000.0 [1]
2-(2-Benzyl-6-chloro-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5015000.0 [1]
2-(2-Benzyl-5,7-dichloro-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5010000.0 [1]
2-(2-Benzyl-7-chloro-1-sulfanylidene-3,4-dihydropyrido[3,4-b]indol-9-yl)acetic acidIC5021000.0 [1]
2-{6-Fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC507500.0 [1]
2-[6-(Morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl]acetic acidIC5044000.0 [1]
2-{3-[(5-Fluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC506400.0 [1]
2-{3-[(6-Fluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC504500.0 [1]
2-(3-{[5-(Trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-1H-indol-1-yl)acetic acidIC505600.0 [1]
2-(5-Methyl-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-1H-indol-1-yl)acetic acidIC5010200.0 [1]
2-{6-Chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC502700.0 [1]
2-{6-Phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC506100.0 [1]
2-{5-Fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5021000.0 [1]
2-{6-Methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5012000.0 [1]
2-{7-Chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5019000.0 [1]
2-{5-Phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5010000.0 [1]
2-{5-Phenoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5011000.0 [1]
2-(6-Bromo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-1H-indol-1-yl)acetic acidIC503400.0 [1]
2-{3-[(4,5,7-Trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}propanoic acidIC506500.0 [1]
2-{5-Methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5021000.0 [1]
2-{2-Phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5016000.0 [1]
3-{3-[(4,5,7-Trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}propanoic acidIC5088000.0 [1]
2-{5-Chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5011000.0 [1]
2-[5-(Morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl]acetic acidIC5041000.0 [1]
2-{4-Chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5014000.0 [1]
2-[5-(Benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl]acetic acidIC504800.0 [1]
2-{2-Methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5013000.0 [1]
2-{5-Methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5034000.0 [1]
2-{7-Methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5021000.0 [1]
2-{7-Fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC507000.0 [1]
2-{3-[(6-Chloro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC502100.0 [1]
2-{6-Methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5013000.0 [1]
2-{7-Bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acidIC5018000.0 [1]
Items per page: 1 - 10 of 64
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References

This online tool may be cited as follows

MLA

"Quest Database™ Aldehyde reductase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/aldehyde-reductase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Aldehyde reductase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/aldehyde-reductase-inhibitors-ic50-ki.
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