 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 19.6 [1] |
| 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | Ki | 5.5 [1], 26.1 [2] |
 | 1-[4-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 77.0 [1] |
| 1-[4-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | Ki | 7.2 [1], 23.3 [2] |
 | 4-(Diethylamino)benzaldehyde | IC50 | 57.0 [1], 520.0 [2], 1700.0 [3], 3400.0 [4] |
 | Ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate | IC50 | 4600.0 [1], 6890.0 [2], 57000.0 [3] |
| Ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate | Ki | 230.0 [1] |
 | 7-Diethylamino-4-methylcoumarin | IC50 | 760.0 [1] |
| 7-Diethylamino-4-methylcoumarin | Ki | 870.0 [1], 1200.0 [2] |
 | 1-Benzyl-1H-indole-2,3-dione | IC50 | 10.0 [1], 20.0 [2], 4870.0 [3] |
 | 8-[6-Methoxy-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane | IC50 | 17.0 [1], 50.0 [2], 3430.0 [3] |
 | 6-[(3-Fluorobenzyl)thio]-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 900.0 [1] |
| 6-[(3-Fluorobenzyl)thio]-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | Ki | 380.0 [1] |
 | 8-[[4-(Furan-2-carbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione | IC50 | 800.0 [1] |
| 8-[[4-(Furan-2-carbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione | Ki | 720.0 [1], 800.0 [2] |
 | 7-Bromo-5-methyl-1H-indole-2,3-dione | IC50 | 720.0 [1] |
| 7-Bromo-5-methyl-1H-indole-2,3-dione | Ki | 290.0 [1], 900.0 [2] |
 | 2-[(2-Butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(2-methylphenyl)butanamide | IC50 | 119.0 [1], 390.0 [2], 1010.0 [3] |
 | 2-(3,4-Dimethoxyphenyl)-2-oxoethyl thiocyanate | IC50 | 1000.0 [1], 3100.0 [2] |
 | 1-[[1,3-Dimethyl-2,6-dioxo-7-(3-phenylpropyl)purin-8-yl]methyl]piperidine-4-carboxamide | IC50 | 2000.0 [1] |
| 1-[[1,3-Dimethyl-2,6-dioxo-7-(3-phenylpropyl)purin-8-yl]methyl]piperidine-4-carboxamide | Ki | 240.0 [1] |
 | 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione | IC50 | 41.0 [1], 6790.0 [2] |
 | 2,3,5-Trimethyl-6-[3-Oxo-3-(Piperidin-1-Yl)propyl]-7h-Furo[3,2-G][1]benzopyran-7-One | IC50 | 130.0 [1] |
| 2,3,5-Trimethyl-6-[3-Oxo-3-(Piperidin-1-Yl)propyl]-7h-Furo[3,2-G][1]benzopyran-7-One | Ki | 170.0 [1] |
 | Cyclopropyl-[4-[[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinolin-3-yl]methyl]piperazin-1-yl]methanone | IC50 | 28.0 [1], 12400.0 [2] |
 | [4-[6-Chloro-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 13.0 [1], 1970.0 [2] |
 | 1-[1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidin-4-yl]ethanone | IC50 | 11.0 [1], 106.0 [2] |
 | 1-[4-[6-Chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 7.0 [1], 53.0 [2] |
 | [4-[4-(6-Azaspiro[2.5]octan-6-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 67.0 [1], 4040.0 [2] |
 | 4-[4-[4-(1-Cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide | IC50 | 6.0 [1], 31.0 [2] |
 | 1-[4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 6.0 [1], 47.0 [2] |
 | 4-Methyl-1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]piperidine-4-carbonitrile | IC50 | 32.0 [1], 1210.0 [2] |
 | 1-[6-Fluoro-3-[4-(2-methylpropanoyl)piperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 27.0 [1], 1480.0 [2] |
 | 2-[3-Fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile | IC50 | 9.0 [1], 96.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-ethylpiperidine-4-carbonitrile | IC50 | 15.0 [1], 153.0 [2] |
 | 1-[4-[7-Methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 5.0 [1], 74.0 [2] |
 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(2-fluorophenyl)piperidine-4-carbonitrile | IC50 | 7.0 [1], 32.0 [2] |
 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(4-fluorophenyl)piperidine-4-carbonitrile | IC50 | 11.0 [1], 87.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 50.0 [1], 2460.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-dimethoxyquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 35.0 [1], 2220.0 [2] |
 | 2-[4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]-2-methylpropanenitrile | IC50 | 6.0 [1], 32.0 [2] |
 | 1'-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[1H-indene-3,4'-piperidine]-2-one | IC50 | 18.0 [1], 472.0 [2] |
 | 4-[4-(4-Cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide | IC50 | 24.0 [1], 1450.0 [2] |
 | 1-[3-Fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 16.0 [1], 486.0 [2] |
 | 1-[6-Fluoro-3-[(3R)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 388.0 [1], 5380.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,8-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 23.0 [1], 2880.0 [2] |
 | [4-[4-(2-Azaspiro[4.5]decan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 35.0 [1], 5610.0 [2] |
 | 4-Benzyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile | IC50 | 574.0 [1], 4510.0 [2] |
 | 1-[4-[6-Methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 7.0 [1], 42.0 [2] |
 | 1-[3-(4-Cyclopropylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 371.0 [1], 6340.0 [2] |
 | 1-[6,7-Difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 12.0 [1], 22.0 [2] |
 | [4-[4-(4-Tert-butylphenyl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 14.0 [1], 39.0 [2] |
 | 1'-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[2H-indene-3,4'-piperidine]-1-one | IC50 | 61.0 [1], 4680.0 [2] |
 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbaldehyde | IC50 | 10.0 [1], 94.0 [2] |
 | 1-[6-Chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 15.0 [1], 48.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-(cyclopropylmethyl)piperidine-4-carbonitrile | IC50 | 13.0 [1], 572.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 19.0 [1], 4090.0 [2] |
 | 2-[4-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile | IC50 | 9.0 [1], 24.0 [2] |
 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile | IC50 | 4830.0 [1], 57000.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 19.0 [1], 2420.0 [2] |
 | Cyclopropyl-[4-[4-(4,4-dimethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 46.0 [1], 2570.0 [2] |
 | 1-[4-[6-(4-Methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 20.0 [1], 507.0 [2] |
 | 1-[6-Chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 14.0 [1], 65.0 [2] |
 | [4-(4-Ethenylsulfonylpiperazin-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone | IC50 | 38.0 [1], 1590.0 [2] |
 | [4-[4-(2-Azaspiro[3.5]nonan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 113.0 [1], 11800.0 [2] |
 | 1-[6-(4-Methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 10.0 [1], 22.0 [2] |
 | 4-Methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)thieno[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile | IC50 | 60.0 [1], 2950.0 [2] |
 | Cyclopropyl-[4-[4-(4,4-diethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 86.0 [1], 4570.0 [2] |
 | [4-(4,4-Dimethylcyclohexen-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone | IC50 | 21.0 [1], 873.0 [2] |
 | 1-[3-(3,3-Dimethyl-4-methylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 4490.0 [1], 57000.0 [2] |
 | [4-[4-(Azepan-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 194.0 [1], 11600.0 [2] |
 | Cyclopropyl-[4-[6-fluoro-4-(1-oxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 43.0 [1], 3550.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile | IC50 | 23380.0 [1], 57000.0 [2] |
 | 4-Methyl-1-[1-methyl-5-(4-methylsulfonylpiperazine-1-carbonyl)pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile | IC50 | 87.0 [1], 5230.0 [2] |
 | Cyclopropyl-[4-[4-(4,4-difluoropiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 2330.0 [1], 57000.0 [2] |
 | Cyclopropyl-[4-[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 13.0 [1], 112.0 [2] |
 | 4-[4-(4-Cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide | IC50 | 14.0 [1], 40.0 [2] |
 | 4-Methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile | IC50 | 193.0 [1], 5440.0 [2] |
 | 1-[7-Methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 14.0 [1], 45.0 [2] |
 | [6-Fluoro-4-(4-hydroxy-4-phenylpiperidin-1-yl)quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone | IC50 | 199.0 [1], 7420.0 [2] |
 | 1-[4-[6-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile | IC50 | 17.0 [1], 319.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-methoxyquinolin-4-yl]piperidin-4-one | IC50 | 26410.0 [1], 57000.0 [2] |
 | 4-[4-[4-(1-Cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide | IC50 | 8.0 [1], 54.0 [2] |
 | 1-[6-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 12.0 [1], 71.0 [2] |
 | 4-Methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile | IC50 | 251.0 [1], 15600.0 [2] |
 | 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 94.0 [1], 5080.0 [2] |
 | Cyclopropyl-[4-[6-fluoro-4-(4-fluoropiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 1900.0 [1], 57000.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoro-8-methylquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 22.0 [1], 3930.0 [2] |
 | [6-Fluoro-4-[4-(hydroxymethyl)-4-phenylpiperidin-1-yl]quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone | IC50 | 80.0 [1], 4110.0 [2] |
 | [4-[4-(4-Benzylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone | IC50 | 2510.0 [1], 17300.0 [2] |
 | 1-[4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperazin-1-yl]ethanone | IC50 | 57000.0 [1] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-7-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 21.0 [1], 2430.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methylquinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 35.0 [1], 2270.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 8.0 [1], 63.0 [2] |
 | Cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 68.0 [1], 9760.0 [2] |
 | 1-[3-[4-(Cyclopropanecarbonyl)piperidine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 89.0 [1], 1570.0 [2] |
 | 1-[5-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[2,3-b]pyridin-4-yl]-4-methylpiperidine-4-carbonitrile | IC50 | 64.0 [1], 2450.0 [2] |
 | Cyclopropyl-[4-[6-fluoro-4-(4-phenylpiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone | IC50 | 597.0 [1], 13600.0 [2] |
 | 4-[4-(4-Cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide | IC50 | 6.0 [1], 40.0 [2] |
 | 1-[6-Methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile | IC50 | 12.0 [1], 32.0 [2] |
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