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AICAR transformylase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
N-(4-((3-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acidIC50700.0 [1], 94000.0 [2]
LometrexolKi100000.0 [1]
2-[[4-[(2-Methyl-4-oxo-3H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acidIC5060000.0 [1]
1,5-Dihydroimidazo[4,5-C][1,2,6]thiadiazin-4(3h)-One 2,2-DioxideKi130.0 [1], 100000.0 [2]
N-(4-{[(2-Amino-4-oxo-3,4-dihydroquinazolin-6-YL)amino]sulfonyl}benzoyl)glutamic acidIC501000.0 [1]
N-(4-{[(2-Amino-4-oxo-3,4-dihydroquinazolin-6-YL)amino]sulfonyl}benzoyl)glutamic acidKi6.0 [1]
7-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,2-dioxo-1H-imidazo[4,5-c][1,2,6]thiadiazin-4-oneKi230.0 [1], 100000.0 [2]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(2,2,4-trioxo-1H-imidazo[4,5-c][1,2,6]thiadiazin-7-yl)oxolan-2-yl]methyl dihydrogen phosphateKi150.0 [1], 100000.0 [2]
MethotrexateIC5020000.0 [1]
VeratridineIC50231300.0 [1]
AICA ribonucleotideIC5025000.0 [1]
Yellow 2GIC5020100.0 [1]
3,20-Dioxopregn-4-en-21-yl 4-bromobenzenesulfonateIC5013900.0 [1]
FaicarKi400.0 [1]
DdathfIC50130000.0 [1]
2-{4-[(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acidIC506400.0 [1]
Dideazaacyclotetrahydrofolic acidKi20000.0 [1]
4-[2-(3-Carboxy-4-hydroxynaphthalen-1-yl)-2-oxoacetyl]-1-hydroxynaphthalene-2-carboxylic acidIC508800.0 [1]
2-[[4-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acidIC5030000.0 [1]
1-Naphthalenesulfonic acid, 3-((4-sulfo-2-naphthalenyl)-NNO-azoxy)-IC507800.0 [1]
2-[[4-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methylamino]benzoyl]amino]pentanedioic acidIC5030000.0 [1]
2-[[4-[6-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl]benzoyl]amino]-4-(2H-tetrazol-5-yl)butanoic acidKi46000.0 [1]
(2S)-2-[[4-[(2-Amino-4-oxo-3H-quinazolin-6-yl)sulfonylamino]benzoyl]amino]pentanedioic acidKi8.0 [1]
Benzenesulfonic acid, 2-[(4-aminobenzoyl)amino]-5-(6-methyl-2-benzothiazolyl)-IC5016900.0 [1]
4-{[(5-Aminonaphthalen-2-yl)sulfonyl]amino}benzoic acidIC504100.0 [1]
4-Cyano-N-phenylbenzenesulfonamideIC50100000.0 [1]
N-[4-(Quinoxalin-2-ylsulfamoyl)phenyl]acetamideIC5054700.0 [1]
3-Iodo-N-[2-[[2-[(4-methoxyphenyl)methylamino]-2-oxoethyl]-[2-oxo-2-(2-phenylethylamino)ethyl]amino]-2-oxoethyl]benzamideKi3100.0 [1]
5-[(4R)-3,3-Difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC5012.0 [1]
5-[(3R,4S)-3-Fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC5020.0 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-(4-hydroxypiperidin-1-yl)thiophene-2-sulfonamideIC5013.0 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamideIC5016.0 [1]
5-(5-Ethyl-5-methyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC505.0 [1]
5-[(4S)-3,3-Difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC5013.0 [1]
5-[(3S,4R)-3-Fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC507.8 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3S)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamideIC5014.0 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3S)-3-hydroxypiperidin-1-yl]thiophene-2-sulfonamideIC5018.0 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3R)-3-hydroxypiperidin-1-yl]thiophene-2-sulfonamideIC5026.0 [1]
5-(5,5-Dimethyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamideIC505.0 [1]
7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-oneIC5095000.0 [1]
(2S)-2-[[4-[6-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
4-[6-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl]-N-(2H-tetrazol-5-ylmethyl)benzamideKi100000.0 [1]
2-[[4-[6-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl]benzoyl]amino]acetic acidKi100000.0 [1]
2-[[4-(11-Amino-13-oxo-4,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),2,5,7,10-pentaen-4-yl)benzoyl]amino]pentanedioic acidIC5017000.0 [1]
(2S)-2-[[4-[(1S)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methylsulfanylbutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
(2S)-2-[[4-[(1R)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methylsulfanylbutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
5-Chloro-2-[5-methyl-4-[[4-(4-methylphenoxy)sulfonylphenyl]diazenyl]-3-oxo-1H-pyrazol-2-yl]benzenesulfonic acidIC503300.0 [1]
2-[[4-[[(2-Amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acidIC5062800.0 [1]
2-[[4-[[(2-Amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acidIC50141000.0 [1]
2-[[4-[[(2-Amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)-formylamino]methyl]benzoyl]amino]pentanedioic acidIC5049900.0 [1]
2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acidIC50100000.0 [1]
2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acidIC50100000.0 [1]
(2S)-2-[[4-[(1S)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-hydroxybutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
(2S)-2-[[4-[(1R)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-hydroxybutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
(2S)-2-[[4-[(1R)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methoxybutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
(2S)-2-[[4-[2-[3-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)propyl]-1,3-dithian-2-yl]benzoyl]amino]pentanedioic acidKi20000.0 [1]
(2S)-2-[[4-[(1S)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methoxybutyl]benzoyl]amino]pentanedioic acidKi100000.0 [1]
10-Trifluoroacetyl-DDACTHFKi100000.0 [1]
2-[[4-[(2-Amino-4-oxo-3H-quinazolin-6-yl)methyl-[(4-fluoro-3-nitrophenyl)methyl]amino]benzoyl]amino]pentanedioic acidKi17000.0 [1]
2-[[4-[(2-Amino-4-oxo-3H-quinazolin-6-yl)methyl-[(3-fluoro-4-nitrophenyl)methyl]amino]benzoyl]amino]pentanedioic acidKi52000.0 [1]
2-[[4-[2-(2-Amino-4-oxo-3H-pyrido[3,2-d]pyrimidin-6-yl)ethylamino]benzoyl]amino]pentanedioic acidIC5040000.0 [1]
2-[[4-[2-(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[3,2-d]pyrimidin-6-yl)ethylamino]benzoyl]amino]pentanedioic acidIC5020000.0 [1]
2-[[4-[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acidIC5020000.0 [1]
2-[[4-[2-(2-Amino-5-ethyl-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino]pentanedioic acidIC5020000.0 [1]
2-[[4-[2-(2-Amino-5-methyl-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino]pentanedioic acidIC5020000.0 [1]
2-[[4-(11-Amino-13-oxo-4,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10-dien-4-yl)benzoyl]amino]pentanedioic acidIC5040000.0 [1]
2,6-Diamino-5-[6-(1,3-benzoxazol-2-yl)-6-oxohexyl]pyrimidin-4(1H)-oneKi100000.0 [1]
4-Cyano-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)benzenesulfonamideIC50723.0 [1]
N-(2-Amino-4-oxo-3H-quinazolin-6-yl)-4-cyanobenzenesulfonamideIC5018100.0 [1]
N-(6-Fluoro-1-oxo-2H-isoquinolin-7-yl)-5-(6-oxo-1H-pyridin-3-yl)thiophene-2-sulfonamideIC505.0 [1]
4-Cyano-N-(1-oxo-2H-isoquinolin-7-yl)benzenesulfonamideIC50608.0 [1]
3-[(4-Cyanophenyl)sulfonylamino]benzamideIC5090000.0 [1]
5-[(5-Sulfamoylnaphthalen-2-yl)diazenyl]naphthalene-1-sulfonic acidKi154.0 [1]
4-[3-Methyl-4-[[3-methyl-4-(phenylsulfamoyl)phenyl]diazenyl]-5-oxo-4H-pyrazol-1-yl]benzenesulfonic acidIC5011600.0 [1]
5-Hydroxy-8-[4-(4-sulfo-phenylazo)-phenylazo]-naphthalene-1-sulfonic acidIC5011600.0 [1]
(2R)-2-[[4-[[(6R)-2-Amino-4-oxo-4a,5,6,7,8,8a-hexahydro-3H-pteridin-6-yl]methyl-formylamino]benzoyl]amino]pentanedioic acidIC5050000.0 [1]
(2R)-2-[[4-[(2-Amino-4-oxo-4a,8a-dihydro-3H-pyrido[3,2-d]pyrimidin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acidIC506400.0 [1]
3-Iodo-N-{[(phenethylcarbamoyl-methyl)-carbamoyl]-methyl}-benzamideKi8000.0 [1]
N-[(E)-[(8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]amino]-4-methylbenzenesulfonamideIC509600.0 [1]
4-Methyl-N-(7-nitro-1,3-benzothiazol-5-yl)benzenesulfonamideIC5036100.0 [1]
4-[(2Z)-2-(3-Carboxy-4-oxonaphthalen-1-ylidene)-1-phenylethyl]-1-hydroxynaphthalene-2-carboxylic acidIC50203700.0 [1]
(2S)-2-[[4-[(2-Amino-4-oxo-4a,8a-dihydro-3H-pyrido[3,2-d]pyrimidin-6-yl)methyl-[(E)-3-[5-carbamoyl-3-[(3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]prop-2-enoyl]amino]benzoyl]amino]pentanedioic acidIC50125.0 [1]
1,5-Naphthalenedisulfonic acid, 3-[(4-amino-2-methylphenyl)azo]-IC507600.0 [1]
4-Chloro-N-(1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)benzenesulfonamideIC5034800.0 [1]
Items per page: 1 - 10 of 84
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References

This online tool may be cited as follows

MLA

"Quest Database™ AICAR transformylase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/aicar-transformylase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ AICAR transformylase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/aicar-transformylase-inhibitors-ic50-ki.
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