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Adrenergic receptor alpha-2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
YohimbineIC508.0 [1], 95.0 [2]
YohimbineKi3.8 [1]
OxymetazolineKi14.0 [1]
PrazosinKi540.0 [1]
RauwolscineKi1.2 [1]
ClonidineIC5021.0 [1]
ClonidineKi3.8 [1], 20.89 [2]
CorynanthineIC50211000.0 [1], 340000.0 [2], 871000.0 [3], 1038000.0 [4]
BrimonidineIC503.0 [1]
BrimonidineKi1.41 [1], 2.4 [2]
OlanzapineKi140.0 [1], 230.0 [2], 263.0 [3]
2-MethoxyidazoxanKi0.91 [1], 1.41 [2]
EpinephrineIC508.0 [1]
EpinephrineKi5.0 [1]
ClozapineKi51.0 [1], 160.0 [2]
RisperidoneKi1.8 [1], 7.5 [2]
QuetiapineKi87.0 [1], 1100.0 [2]
ZiprasidoneKi390.0 [1]
CisaprideIC504500.0 [1]
IdazoxanKi51.29 [1]
MedetomidineIC502900.0 [1], 3300.0 [2]
ZotepineKi180.0 [1], 960.0 [2]
1,2,3,4-Tetrahydroisoquinoline-7-sulfonamideKi100000.0 [1]
4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochlorideIC5010000.0 [1]
4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochlorideKi10000.0 [1]
4-(1-Naphthalen-1-yl-ethyl)-1H-imidazoleIC500.0 [1], 4300.0 [2]
4-Amino-N-[(4R)-1-azatricyclo[3.3.1.03,7]nonan-4-yl]-5-chloro-2-methoxybenzamideIC5010000.0 [1]
N-(4,5-Dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amineKi1.3 [1]
N-(4,5-Dihydro-1H-imidazol-2-yl)-5-methyl-1,2,3,4-tetrahydroquinoxalin-6-amineKi6.8 [1], 9.6 [2]
N-(4,5-Dihydro-1H-imidazol-2-yl)quinoxalin-6-amineKi41.0 [1], 64.0 [2]
5-O-[2-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl-methylamino]ethyl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylateIC501000.0 [1], 100000.0 [2]
NorepinephrineKi30.0 [1]
PhenylephrineKi390.0 [1]
HaloperidolKi5000.0 [1]
PhentolamineKi5.0 [1]
NicardipineIC5010000.0 [1]
ZafirlukastIC5010000.0 [1]
MoxonidineKi75.0 [1]
ApraclonidineIC504.0 [1]
SertindoleKi1680.0 [1]
RilmenidineKi180.0 [1]
IpsapironeIC501000.0 [1]
Naphazoline hydrochlorideIC500.0 [1]
XylometazolineKi500.0 [1]
EfaroxanKi51.29 [1]
GR-127935Ki1000.0 [1]
VilazodoneIC506000.0 [1]
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineKi21.0 [1]
BenalfocinKi16.7 [1]
6-FluoronorepinephrineKi12.0 [1]
1-(1-Methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)ureaKi1000.0 [1]
p-IodoclonidineIC501.5 [1]
N-DesmethylolanzapineKi1000.0 [1]
4-(2-Amino-1-hydroxyethyl)-3-fluorobenzene-1,2-diolKi700.0 [1]
[2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimethyl-amineKi300.0 [1]
3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamideKi1400000.0 [1]
5-Fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indoleKi400.0 [1]
4-N-(4,5-Dihydro-1H-imidazol-2-yl)-1-N-[4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl]benzene-1,4-diamineKi57.54 [1]
7-Bromo-1,2,3,4-tetrahydro-3-(trifluoromethyl)-isoquinolineKi1000000.0 [1]
Amino({4-[(4-{[amino(iminio)methyl]amino}phenyl)amino]phenyl}amino)methaniminiumKi1000.0 [1]
3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dioneKi1000.0 [1]
7-Iodo-1,2,3,4-tetrahydroisoquinolineKi220.0 [1]
1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazineKi181.0 [1]
1H-Imidazole, 2-(2-fluoro-5-methylphenyl)-4,5-dihydro-Ki10000.0 [1]
Guanidine, 4,4'-methylenediphenyldi-Ki416.87 [1]
N-[4-[[4-(4,5-Dihydro-1H-imidazol-2-ylamino)phenyl]methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amineKi1.58 [1]
N-(2-Chloro-4-iodophenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amineKi2500.0 [1]
7-Nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineKi1400000.0 [1]
3-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinolineKi31000.0 [1]
2-[4-[4-(Diaminomethylideneamino)benzoyl]phenyl]guanidineKi6309.57 [1]
3-[2-(Azepan-1-yl)ethyl]-6-propyl-1,3-benzothiazol-2-oneKi205.0 [1]
2-Oxazolamine, 5-[(2-bromophenoxy)methyl]-4,5-dihydro-Ki10000.0 [1]
Bis[4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl]methanoneKi1584.89 [1]
N-((Hexahydro-1H-pyrrolizin-1-yl)methyl)-6-chloroimidazo(1,2-a)pyridine-8-carboxamide hydrochlorideIC5010000.0 [1]
6-Chloro-3-methyl-9-prop-2-enoxy-1,2,4,5-tetrahydro-3-benzazepineKi48.0 [1]
3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineKi400000.0 [1]
2-(1,4-Benzodioxan-6-ylamino)-2-imidazolineKi3.1 [1]
7-Methanesulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinolineKi3900000.0 [1]
3-Fluoro-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatecholKi66.0 [1]
2-(2,6-Dichloro-4-nitrophenylimino)imidazolidineIC5010000.0 [1]
2-Hydroxymethyl OlanzapineKi783.0 [1]
Imidazolidine, 2-(2-methylphenylimino)-Ki7.8 [1]
3-[2-[4-(2-Chlorophenyl)-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dioneKi100000.0 [1]
7-Isoquinolinecarbonitrile, 1,2,3,4-tetrahydro-3-(trifluoromethyl)-Ki2900000.0 [1]
4-[1-Hydroxy-2-(methylamino)ethyl]-5-fluoropyrocatecholKi9.0 [1]
(E)-N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC501.3 [1]
N-(Dicyclopropylmethyl)-2,3-dimethyl-3,4-dihydro-2H-pyrrol-5-amineKi10000.0 [1]
N-(2,6-Dichlorophenyl)-5-methyl-4,5-dihydro-1H-imidazol-2-amineKi1949.0 [1]
2-Fluoro-3-[1-hydroxy-2-(methylamino)ethyl]phenolKi1200.0 [1]
Benzeneethanamine, 4-fluoro-beta,3-dihydroxy-N-methyl-Ki1000.0 [1]
1-[(Dimethylamino)methyl]-2,3-dihydro-1H-indene-4,5-diolKi25.0 [1]
1H-Indene-4,5-diol, 2,3-dihydro-1-[(methylamino)methyl]-Ki7.0 [1]
1H-Indene-4,5-diol, 1-(aminomethyl)-2,3-dihydro-Ki15.0 [1]
1-[(Dipropylamino)methyl]-2,3-dihydro-1H-indene-4,5-diolKi470.0 [1]
1H-Indene-5,6-diol, 1-(aminomethyl)-2,3-dihydro-Ki520.0 [1]
N-[4-[4-(4,5-Dihydro-1H-imidazol-2-ylamino)phenoxy]phenyl]-4,5-dihydro-1H-imidazol-2-amineKi100.0 [1]
N-[4-[4-(4,5-Dihydro-1H-imidazol-2-ylamino)phenyl]sulfanylphenyl]-4,5-dihydro-1H-imidazol-2-amineKi18.2 [1]
Benzeneethanamine, 2-fluoro-beta,5-dihydroxy-N-methyl-Ki230.0 [1]
2-[4-[4-(Diaminomethylideneamino)phenyl]sulfanylphenyl]guanidineKi269.15 [1]
7-Bromo-3-methyl-1,2,3,4-tetrahydroisoquinolineKi1100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Adrenergic receptor alpha-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 28 Mar. 2025, https://www.aatbio.com/data-sets/adrenergic-receptor-alpha-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, March 28). Quest Database™ Adrenergic receptor alpha-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/adrenergic-receptor-alpha-2-inhibitors-ic50-ki.
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