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Acyl-CoA desaturase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1'-[6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]IC500.03 [1], 0.06 [2], 0.8 [3]
MK-8245IC501.0 [1], 5.0 [2], 1066.0 [3], 1070.0 [4]
N-(2-Hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamideIC5028.0 [1], 43.0 [2]
N-[5-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC500.2 [1], 0.3 [2], 26.0 [3]
N-[(2R)-2-Hydroxy-2-phenylethyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5015.0 [1], 25.0 [2], 71.0 [3]
N-[(2S)-2-Hydroxy-2-phenylethyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5060.0 [1], 81.0 [2], 90.0 [3]
N-(2-Hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamideIC507.0 [1], 15.0 [2], 51.0 [3]
N-(2-Hydroxy-2-phenylethyl)-6-(4-oxospiro[3H-chromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamideIC500.69 [1], 50.0 [2], 250.0 [3]
2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamideIC50254.0 [1], 300.0 [2]
3-(2-Hydroxyethoxy)-4-methoxy-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)benzamideIC503.0 [1]
N-Phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamideIC509.0 [1], 18.0 [2]
5-Fluoro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC500.3 [1], 0.7 [2]
N-Benzyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5041.0 [1], 750.0 [2]
N-(2-(7-(3,4-Dichlorobenzylamino)-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl)ethyl)acetamideIC508.6 [1]
N-[2-[3-(4-Methoxyphenyl)-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamideIC503.3 [1], 33.0 [2]
1'-[6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC501.0 [1], 4.0 [2]
N-(3-(4-Chloro-3-(trifluoromethyl)benzyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-2-hydroxyacetamideIC50110.0 [1]
N-[2-[7-[[4-Chloro-3-(trifluoromethyl)phenyl]methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamideIC500.05 [1]
1'-[6-[5-(Pyridin-2-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC504.0 [1], 9.0 [2]
1'-[6-[5-(Pyridin-4-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC506.0 [1], 7.0 [2]
6-(5-Fluorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamideIC506.0 [1], 7.0 [2]
5-Chloro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC500.06 [1], 1.0 [2]
6-(5-Chlorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamideIC501.0 [1], 2.0 [2]
N-(2-Hydroxy-2-pyridin-3-ylethyl)-6-[5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl]pyridazine-3-carboxamideIC500.45 [1], 3.0 [2]
5-{6-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}nicotinic acidIC507.0 [1], 6030.0 [2]
2-[5-[3-[3-(2-Bromo-5-fluorophenoxy)propoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acidIC5041.0 [1], 7740.0 [2]
N-[5-[(3-Chloro-4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC502.0 [1], 17.0 [2]
3-(2-Hydroxyethoxy)-4-methoxy-N-[5-[[3-(trifluoromethoxy)phenyl]methyl]-1,3-thiazol-2-yl]benzamideIC504.0 [1], 59.0 [2]
N-[5-[(3-Fluoro-4-methylphenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC5082.0 [1], 639.0 [2]
N-(5-(3-Chlorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamideIC504.0 [1], 9.0 [2]
N-[5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC501.0 [1], 13.0 [2]
N-[5-[(3,5-Difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC502.9 [1], 116.0 [2]
N-[5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC501.0 [1], 13.0 [2]
N-[5-[[4-Fluoro-3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC500.6 [1], 8.0 [2]
N-[5-[(3,4-Difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC509.0 [1], 34.0 [2]
N-(5-(3-Fluorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamideIC5011.0 [1], 34.0 [2]
N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamideIC50125.0 [1], 429.0 [2]
N-[2-(4-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC505.0 [1], 22.0 [2]
N-(2-Hydroxy-2-thiophen-3-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC507.0 [1], 21.0 [2]
6-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamideIC5080.0 [1], 118.0 [2]
N-(2-Hydroxy-2-pyridin-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC50180.0 [1], 390.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-[4-(2-methoxybenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC50311.0 [1], 1048.0 [2]
N-[2-(2-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC5022.0 [1], 60.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperidin-1-yl]pyridazine-3-carboxamideIC507.0 [1], 14.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethoxy)benzoyl]piperidin-1-yl]pyridazine-3-carboxamideIC5010.0 [1], 103.0 [2]
N-(2-Hydroxy-2-thiophen-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC5025.0 [1], 44.0 [2]
N-(2-Hydroxy-2-pyridin-4-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC50144.0 [1], 187.0 [2]
6-(4-Benzoylpiperidin-1-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamideIC50108.0 [1], 292.0 [2]
N-[2-(3-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamideIC506.0 [1], 11.0 [2]
N-(2-Hydroxy-2-pyridin-3-ylethyl)-6-(5-methylspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamideIC501.0 [1], 6.0 [2]
6-(5,8-Difluorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamideIC502.0 [1], 7.0 [2]
1-(Pyridin-3-ylmethyl)-3-[6-[5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl]pyridazin-3-yl]ureaIC5010.0 [1], 106.0 [2]
1'-[6-[5-(Pyridin-3-ylmethyl)-1H-1,2,4-triazol-3-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]IC501.0 [1], 4.0 [2]
1'-[6-[2-Methyl-5-(pyridin-3-ylmethyl)-1,2,4-triazol-3-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]IC5038.0 [1], 65.0 [2]
1'-[6-[5-(2-Pyridin-3-ylethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]IC5016.0 [1], 35.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-(4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamideIC500.48 [1], 16.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-(3-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamideIC500.56 [1], 49.0 [2]
N-(2-Hydroxy-2-phenylethyl)-6-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamideIC500.07 [1], 2.7 [2]
N-(2-Hydroxy-2-phenylethyl)-6-spiro[1,4-dihydroisochromene-3,4'-piperidine]-1'-ylpyridazine-3-carboxamideIC5076.0 [1], 400.0 [2]
6-(5-Fluoro-4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamideIC5017.0 [1], 157.0 [2]
2-[5-[3-[2-(2-Chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acidIC5027.0 [1], 9900.0 [2]
5,8-Difluoro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC500.1 [1], 1.0 [2]
5-Methyl-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine]IC500.2 [1], 0.7 [2]
N-(Pyridin-3-ylmethyl)-6-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamideIC5027.0 [1], 76.0 [2]
6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindoleIC5015.0 [1], 39.0 [2]
6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indoleIC5011.0 [1], 25.0 [2]
6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indazoleIC509.0 [1], 51.0 [2]
5-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N,N-dimethylpyridin-2-amineIC5012.0 [1], 30.0 [2]
[1-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-4-yl]methanolIC506.0 [1], 21.0 [2]
1-[1-[6-(1-Methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-(trifluoromethyl)-2,3-dihydroindoleIC5016.0 [1], 42.0 [2]
[4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]phenyl]methanolIC507.0 [1], 8.0 [2]
6-Fluoro-1-[1-[6-(6-methoxypyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindoleIC504.0 [1], 79.0 [2]
2-[4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]ethanolIC5017.0 [1], 21.0 [2]
2-[4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]-N-methylacetamideIC5011.0 [1], 12.0 [2]
6-Methyl-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindoleIC50241.0 [1], 422.0 [2]
6-Fluoro-1-[1-[6-[4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindoleIC5031.0 [1], 54.0 [2]
6-Fluoro-1-[1-[6-(4-methylpyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindoleIC5011.0 [1], 23.0 [2]
Sterculic acidIC50300.0 [1]
Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-(4-(2-(trifluoromethyl)phenoxy)-1-piperidinyl)-IC5021.0 [1]
2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazoleIC50670.0 [1]
[5-[6-[4-(Trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]piperidin-1-yl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl]methanolIC504.7 [1]
N-(2-Cyclopropylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamideIC5039.0 [1]
N-(2-Cyclopropylethyl)-6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5012.0 [1]
N-(3-(3,4-Dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-2-hydroxyacetamideIC50119.0 [1]
N-(3-Methylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5037.0 [1]
4-(Ethylamino)-3-(2-hydroxyethoxy)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)benzamideIC500.04 [1]
6-[5-(Cyclopropylmethyl)spiro[3,4-dihydro-1,5-benzoxazepine-2,4'-piperidine]-1'-yl]-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamideIC5010.0 [1]
N-Phenyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC50125.0 [1]
3-(4-Methoxyphenyl)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acrylamideIC503.0 [1]
6-[4-[2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamideIC505870.0 [1]
N-(2-Cyclopropylethyl)-6-[4-[3-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5066.0 [1]
N-(4-Cyclopropylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC50100.0 [1]
N-(2-Cyclopropylethyl)-6-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamideIC5024.0 [1]
N-Hexyl-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyrimidine-2-carboxamideIC506400.0 [1]
6-[4-[5-Chloro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamideIC5018.0 [1]
N-(3-Methylbutyl)-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridine-2-carboxamideIC502400.0 [1]
N-(2-Cyclopropylethyl)-6-[4-[5-methyl-2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamideIC5062.0 [1]
N-Phenethyl-5-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)picolinamideIC50250.0 [1]
N-(2-Cyclopropylethyl)-6-[4-(2,5-dichlorobenzoyl)piperazin-1-yl]pyridazine-3-carboxamideIC50101.0 [1]
N-(2-Cyclopropylethyl)-6-[4-[2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamideIC50290.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acyl-CoA desaturase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/acyl-coa-desaturase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Acyl-CoA desaturase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acyl-coa-desaturase-inhibitors-ic50-ki.
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