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Activin receptor type-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC503.26 [1], 17.0 [2], 40.7 [3]
4-[6-(4-Propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC50100.0 [1], 107.9 [2]
DorsomorphinIC5067.5 [1], 148.1 [2]
1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazineIC5024.0 [1], 27.0 [2]
(4S,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dioneIC50217.0 [1], 3353.0 [2]
StaurosporineIC5010005.0 [1]
Nvp-aew541IC502900.0 [1]
VactosertibIC5010000.0 [1]
3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]phenolIC5035.0 [1]
5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC5026.2 [1]
5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC5032.0 [1]
4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC505090.0 [1]
4-[2-[4-(3-Phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholineIC502570.0 [1]
4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC505130.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC5010000.0 [1]
4-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC5033.3 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
CID 60182364IC505.0 [1]
CID 60182389IC505.0 [1]
4-(4-(3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholineIC5053.4 [1]
TilfrinibIC50220.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC509.0 [1]
5-(3-Piperazin-1-ylphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amineIC5017.0 [1]
5-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylpyridin-2-amineIC50120.0 [1]
5-(4-Piperazin-1-ylphenyl)-3-(3-propan-2-yloxyphenyl)pyridin-2-amineIC50790.0 [1]
3-(4-Chloro-3-methoxyphenyl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC5063.0 [1]
3-(3,4-Dimethoxyphenyl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC5023.0 [1]
3-(3-Methoxy-4-methylphenyl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC50110.0 [1]
3-(3-Methoxyphenyl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC5086.0 [1]
6-(4-Piperazin-1-ylphenyl)-3-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidineIC5010.0 [1]
3-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamideIC50109.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzenesulfonamideIC50246.0 [1]
2-Amino-4-[6-[4-[(2R,6S)-2,6-dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamideIC50291.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5019.0 [1]
4-[6-[4-(2-Piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5063.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-dimethylnaphthalene-1-sulfonamideIC505990.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N-methylnaphthalene-1-sulfonamideIC50326.0 [1]
4-[6-[4-(2-Methyl-1-piperidin-1-ylpropan-2-yl)oxyphenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5047.0 [1]
6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]-3-(4-methylsulfonylphenyl)pyrazolo[1,5-a]pyrimidineIC501971.0 [1]
4-[6-(6-Piperazin-1-ylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC50422.0 [1]
4-[6-[4-(2-Aminopropan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5029.0 [1]
4-[6-[6-(2-Piperidin-1-ylethoxy)pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC50738.0 [1]
N-[4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalen-1-yl]methanesulfonamideIC50796.0 [1]
4-[6-[4-(Pyrrolidin-1-ylmethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5027.0 [1]
4-[6-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5048.0 [1]
4-[6-[4-(1-Aminocyclobutyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5016.0 [1]
4-[6-[6-[2-(Dimethylamino)ethoxy]pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC501026.0 [1]
4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamideIC50526.0 [1]
5-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5054.0 [1]
4-[6-(4-Piperidin-4-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5093.0 [1]
4-[6-[4-(1-Aminoethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamideIC5025.0 [1]
5-(3-Piperazin-1-ylphenyl)-3-quinolin-4-ylpyridin-2-amineIC50110.0 [1]
5-(4-Piperazin-1-ylphenyl)-3-quinolin-5-ylpyridin-2-amineIC50270.0 [1]
N-[3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]methanesulfonamideIC506.0 [1]
3-(3,5-Dimethoxyphenyl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC5014.0 [1]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(4-piperazin-1-ylphenyl)pyridin-2-amineIC501870.0 [1]
3-(4-Morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-oneIC5032.0 [1]
5-Methyl-6-quinolin-5-yl-3~{H}-quinazolin-4-oneIC50194.0 [1]
2,5-Dimethyl-6-quinolin-4-yl-3~{H}-quinazolin-4-oneIC5042.0 [1]
6-Quinolin-5-yl-3H-quinazolin-4-oneIC50344.0 [1]
6-(1-Methylpyrazol-4-yl)-3H-quinazolin-4-oneIC5018200.0 [1]
6-(1H-Pyrazol-4-yl)-3H-quinazolin-4-oneIC508200.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
Alk2-IN-2IC509.0 [1]
3-[4-(Dimethylamino)phenyl]-6-quinolin-4-ylquinazolin-4-oneIC5068.0 [1]
6-(3,5-Dimethyl-1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC50293.0 [1]
2-Benzyl-5-methyl-6-quinolin-4-yl-3H-quinazolin-4-oneIC50439.0 [1]
6-(5-Methyl-1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC502300.0 [1]
5-Methyl-6-quinolin-4-yl-3H-quinazolin-4-oneIC50220.0 [1]
3-Cyclohexyl-6-quinolin-4-ylquinazolin-4-oneIC501525.0 [1]
3-(3-Morpholin-4-ylpropyl)-6-quinolin-4-ylquinazolin-4-oneIC50165.0 [1]
6-(5-Ethyl-1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-Methyl-6-quinolin-5-yl-3H-quinazolin-4-oneIC50138.0 [1]
3-Methyl-6-quinolin-4-ylquinazolin-4-oneIC50186.0 [1]
6-Pyrazolo[1,5-a]pyridin-3-yl-3H-quinazolin-4-oneIC50653.0 [1]
6-Quinolin-4-yl-3H-quinazolin-4-oneIC50167.0 [1]
3-Phenyl-6-quinolin-4-ylquinazolin-4-oneIC50431.0 [1]
3,8-Dimethyl-7-quinolin-4-yl-2H-isoquinolin-1-oneIC5010.0 [1]
2-Methyl-6-quinolin-4-yl-3H-quinazolin-4-oneIC50248.0 [1]
2-Ethyl-5-methyl-6-quinolin-4-yl-3H-quinazolin-4-oneIC5091.0 [1]
3-Methyl-6-quinolin-5-ylquinazolin-4-oneIC50383.0 [1]
6-(5-Cyclopropyl-1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC50386.0 [1]
4-[2-[4-(3-Quinolin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholineIC5042.77 [1]
6-(4-Methoxyphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidineIC50110.0 [1]
6-(4-Piperazin-1-ylphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidineIC5043.0 [1]
3-Phenyl-6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidineIC5040.72 [1]
2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-DiamineIC5010000.0 [1]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
1-{4-[5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]phenyl}piperazineIC5015.0 [1]
4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-CarboxamideIC507.0 [1]
5-(4-Piperazin-1-ylphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amineIC5010.0 [1]
N-[4-[(6-Chloro-[1,3]dioxolo[4,5-B]pyridin-7-Yl)amino]-2-Pyridyl]cyclopropanecarboxamideIC501.2 [1]
N,N-Dimethyl-3-[4-(3-quinolin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]propan-1-amineIC5026.68 [1]
Items per page: 1 - 10 of 95
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References

This online tool may be cited as follows

MLA

"Quest Database™ Activin receptor type-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/activin-receptor-type-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Activin receptor type-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/activin-receptor-type-1-inhibitors-ic50-ki.
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