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Acetylcholinesterase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TacrineIC50250.0 [1]
TacrineKi36.0 [1]
DonepezilIC5016.0 [1]
DonepezilKi20.5 [1]
GalantamineIC501070.0 [1]
GalantamineKi61.9 [1], 61.96 [2], 250.0 [3], 300.0 [4]
PhysostigmineIC5040.0 [1]
RivastigmineIC503030.0 [1]
(1S,9R,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-oneIC5047.0 [1]
(1S,9R,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-oneKi47.0 [1]
Propidium iodideIC5032300.0 [1]
Propidium iodideKi7140.0 [1]
4,4'-(3-Oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenylbenzenaminium) dibromideIC5018.0 [1], 30.0 [2]
4,4'-(3-Oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenylbenzenaminium) dibromideKi10.0 [1]
EptastigmineIC5022.0 [1]
MemoquinIC501.55 [1]
MemoquinKi2.6 [1]
Edrophonium chlorideIC50200.0 [1], 500.0 [2], 5000.0 [3], 5170.0 [4]
Edrophonium chlorideKi790.0 [1], 800.0 [2], 4800.0 [3]
7-Methoxy-1,2,3,4-tetrahydroacridin-9-amineIC5010500.0 [1]
7-Methoxy-1,2,3,4-tetrahydroacridin-9-amineKi2090.0 [1], 6340.0 [2]
9-Amino-6-chloro-1,2,3,4-tetrahydro-acridineIC509.9 [1]
CaproctamineIC50169.82 [1]
CaproctamineKi0.1 [1], 104.0 [2]
Neostigmine bromideIC5041.0 [1]
Tacrine hydrochlorideIC50205.0 [1]
Tacrine hydrochlorideKi101.0 [1], 225.0 [2]
2H-1-Benzopyran-2-one, 6,7-dimethoxy-3-(4-((methyl(phenylmethyl)amino)methyl)phenyl)-IC5044.5 [1]
2H-1-Benzopyran-2-one, 6,7-dimethoxy-3-(4-((methyl(phenylmethyl)amino)methyl)phenyl)-Ki21.7 [1]
(2-Chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-dimethylazaniumyl]ethylamino]-2-oxoacetyl]amino]ethyl]-dimethylazaniumIC500.7 [1]
(2-Chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-dimethylazaniumyl]ethylamino]-2-oxoacetyl]amino]ethyl]-dimethylazaniumKi5.0 [1]
Ethopropazine hydrochlorideIC501020000.0 [1]
Ethopropazine hydrochlorideKi24700.0 [1], 25000.0 [2], 12100000.0 [3]
LipocrineIC500.25 [1]
Bis(7)-TacrineIC500.81 [1]
[(8Bs)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamateIC5024.0 [1], 349.95 [2], 350.0 [3]
XanthostigmineIC500.3 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazole-6-carboxamideIC508.79 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazole-6-carboxamideKi8.71 [1]
Acridine, 1,2,3,4-tetrahydro-9-amino-7-chloro-IC50550.0 [1]
Pralidoxime chlorideIC50366000.0 [1]
Asoxime chlorideIC5054000.0 [1], 66000.0 [2], 89000.0 [3], 203000.0 [4], 460000.0 [5]
Asoxime chlorideKi25000.0 [1]
BenzilIC50100000.0 [1]
BenzilKi100000.0 [1]
Huprine YIC500.69 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6-methoxybenzo[d]isoxazoleIC508.3 [1], 8.32 [2], 8.8 [3]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6-methoxybenzo[d]isoxazoleKi8.32 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6-bromobenzo[d]isoxazoleIC5050.0 [1], 50.12 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6-bromobenzo[d]isoxazoleKi50.12 [1]
N-[3-[2-(1-Benzylpiperidin-4-yl)ethyl]-1,2-benzoxazol-6-yl]acetamideIC502.8 [1], 2.82 [2]
N-[3-[2-(1-Benzylpiperidin-4-yl)ethyl]-1,2-benzoxazol-6-yl]acetamideKi2.82 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-7-methoxybenzo[d]isoxazoleIC507.08 [1], 7.1 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-7-methoxybenzo[d]isoxazoleKi7.08 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5-methoxybenzo[d]isoxazoleIC507.19 [1], 7.2 [2], 7.24 [3]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5-methoxybenzo[d]isoxazoleKi7.24 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-6-olIC5025.7 [1], 26.0 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-6-olKi25.7 [1]
N-{3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-benzo[d]isoxazol-6-yl}-benzamideIC509.33 [1], 9.4 [2]
N-{3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-benzo[d]isoxazol-6-yl}-benzamideKi9.33 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazoleIC5054.95 [1], 55.0 [2], 210.0 [3]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazoleKi208.93 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-6-amineIC5019.95 [1], 20.0 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-6-amineKi19.95 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5-methylbenzo[d]isoxazoleIC507.76 [1], 7.8 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5-methylbenzo[d]isoxazoleKi7.76 [1]
Benzo[d]isoxazol-3-yl-(1-benzyl-piperidin-4-ylmethyl)-amineIC50319.89 [1], 320.0 [2], 323.59 [3]
Benzo[d]isoxazol-3-yl-(1-benzyl-piperidin-4-ylmethyl)-amineKi323.59 [1]
1-(2-(1-Benzylpiperidin-4-yl)ethyl)isoquinolineIC50218.78 [1], 219.79 [2], 220.0 [3]
1-(2-(1-Benzylpiperidin-4-yl)ethyl)isoquinolineKi218.78 [1]
6-[Ethyl-[(2-methoxyphenyl)methyl]amino]-N-[8-[6-[ethyl-[(2-methoxyphenyl)methyl]amino]hexanoyl-methylamino]octyl]-N-methylhexanamideIC5016.1 [1], 16.22 [2], 17.38 [3], 18.62 [4]
6-[Ethyl-[(2-methoxyphenyl)methyl]amino]-N-[8-[6-[ethyl-[(2-methoxyphenyl)methyl]amino]hexanoyl-methylamino]octyl]-N-methylhexanamideKi12.2 [1]
4-Amino-alpha-diethylamino-o-cresol dihydrochlorideIC5017800.0 [1], 48300.0 [2]
4-Amino-alpha-diethylamino-o-cresol dihydrochlorideKi6300.0 [1], 16000.0 [2], 37400.0 [3], 37700.0 [4]
Donepezil hydrochlorideIC5011.6 [1], 20.0 [2], 32.0 [3], 120.0 [4]
Obidoxime chlorideIC50577000.0 [1], 870000.0 [2], 910000.0 [3], 2210000.0 [4]
ProfenamineIC50260.0 [1], 300.0 [2], 260000.0 [3]
(1R)-7-Chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amineIC500.32 [1], 1.1 [2]
(1R)-7-Chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amineKi0.03 [1], 0.67 [2]
3-(3-(1-Benzylpiperidin-4-yl)propyl)benzo[d]isoxazoleIC509.0 [1], 891.25 [2], 900.0 [3]
3-(3-(1-Benzylpiperidin-4-yl)propyl)benzo[d]isoxazoleKi891.25 [1]
7-Chloro-15-methyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine;hydrochlorideIC500.69 [1], 0.78 [2], 1.07 [3]
7-Chloro-15-methyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine;hydrochlorideKi0.03 [1]
N-{3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-benzo[d]isoxazol-6-yl}-benzenesulfonamideIC5014.0 [1]
N-{3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-benzo[d]isoxazol-6-yl}-benzenesulfonamideKi14.13 [1]
3-[2-(1-Benzyl-4-piperidinyl)ethyl]-1,2-benzisothiazoleIC5097.72 [1], 99.0 [2], 100.0 [3]
3-[2-(1-Benzyl-4-piperidinyl)ethyl]-1,2-benzisothiazoleKi100.0 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazole-6-carbonitrileIC50100.93 [1], 101.0 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)benzo[d]isoxazole-6-carbonitrileKi100.0 [1]
3-(1-Benzyl-piperidin-4-ylmethoxy)-benzo[d]isoxazoleIC502570.4 [1], 2582.26 [2], 2600.0 [3]
3-(1-Benzyl-piperidin-4-ylmethoxy)-benzo[d]isoxazoleKi2570.4 [1]
3-[2-[(1-Phenylmethyl)-4-piperidyl]Ethylamino]-1,2-benzisoxazoleIC50810.0 [1], 812.83 [2]
3-[2-[(1-Phenylmethyl)-4-piperidyl]Ethylamino]-1,2-benzisoxazoleKi812.83 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5,6-dihydroisoxazolo[4,5-g]quinolin-7(8H)-oneIC500.57 [1], 0.58 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-5,6-dihydroisoxazolo[4,5-g]quinolin-7(8H)-oneKi0.58 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6H-isoxazolo[5,4-e]indol-7(8H)-oneIC503.6 [1], 3.63 [2]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6H-isoxazolo[5,4-e]indol-7(8H)-oneKi3.63 [1]
Ethyl 5-amino-4-(4-methoxyphenyl)-2-methyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylateIC5045.0 [1], 105.0 [2], 110.0 [3]
Ethyl 5-amino-4-(4-methoxyphenyl)-2-methyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylateKi109.0 [1]
3-(2-(1-Benzylpiperidin-4-yl)ethyl)-6-morpholinobenzo[d]isoxazoleIC500.8 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetylcholinesterase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/acetylcholinesterase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Acetylcholinesterase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetylcholinesterase-inhibitors-ic50-ki.
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