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Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
NicotineIC501000.0 [1]
NicotineKi1480.0 [1], 5500.0 [2], 6270.0 [3]
BupropionIC507.9 [1], 7900.0 [2]
VareniclineIC501000.0 [1]
VareniclineKi8200.0 [1]
3-(2,4-Dimethoxybenzylidene)anabaseineKi3900.0 [1]
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-IC5060000.0 [1]
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-Ki60000.0 [1]
(S)-3-(Azetidin-2-ylmethoxy)pyridineKi314.0 [1]
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamideIC50100000.0 [1]
Philanthotoxin 343IC5011800.0 [1], 56700.0 [2]
Dideaza-philanthotoxin-12IC50790.0 [1], 15100.0 [2]
(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamideIC5013200.0 [1], 86900.0 [2]
(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC5022300.0 [1], 249000.0 [2]
N-[(2S)-1-(12-Aminododecylamino)-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamideIC502430.0 [1], 104000.0 [2]
(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(3-hydroxyphenyl)propanamideIC505330.0 [1], 59800.0 [2]
(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC5010100.0 [1], 98200.0 [2]
(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC5012600.0 [1], 35000.0 [2]
N-[(2S)-1-[3-[4-(3-Aminopropylamino)butylamino]propylamino]-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamideIC50117000.0 [1], 1000000.0 [2]
(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamideIC505690.0 [1], 25900.0 [2]
(2S)-N-(12-Aminododecyl)-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamideIC50151000.0 [1], 1000000.0 [2]
N-[(2S)-1-[3-[4-(3-Aminopropoxy)butoxy]propylamino]-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamideIC5042600.0 [1], 110000.0 [2]
(2S)-N-(12-Aminododecyl)-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC5017200.0 [1], 388000.0 [2]
(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC5025300.0 [1], 50900.0 [2]
N-[(2S)-1-[3-[4-(3-Aminopropoxy)butoxy]propylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamideIC5010900.0 [1], 72700.0 [2]
(2S)-N-(12-Aminododecyl)-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamideIC508050.0 [1], 105000.0 [2]
(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(3-hydroxyphenyl)propanamideIC504470.0 [1], 30700.0 [2]
TropisetronKi27000.0 [1]
CytisineKi250.0 [1]
Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, monohydrochlorideIC5060000.0 [1]
RadafaxineIC507600.0 [1]
3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octaneKi3000.0 [1]
(S)-1-(2-Fluorophenyl)ethyl (S)-quinuclidin-3-ylcarbamateIC50125892.54 [1]
(1R,2R,4S)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amineIC50300.0 [1]
Rac-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonaneKi5700.0 [1]
1H-1,4-Diazepine-1-pentanamide, 4-acetylhexahydro-N-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-IC5030000.0 [1]
3-(4-Chlorophenyl)-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazoleIC5095000.0 [1]
CID 10107234IC50100000.0 [1]
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamideIC50100000.0 [1]
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzothiophene-6-carboxamideIC50100000.0 [1]
2-(Tert-butyl(methyl)amino)-1-(3-chlorophenyl)propan-1-oneIC5016.0 [1]
2-(Tert-butylamino)-1-(3-fluorophenyl)propan-1-oneIC5032.0 [1]
LaburnamineKi10000.0 [1]
2-(Tert-butylamino)-1-(3-chlorophenyl)butan-1-oneIC503.9 [1]
2-(Tert-butylamino)-1-(3-chlorophenyl)pentan-1-oneIC502.0 [1]
1-(3-Bromophenyl)-2-(tert-butylamino)propan-1-oneIC5010.0 [1]
2-(Tert-butylamino)-1-(4-chlorophenyl)propan-1-oneIC5014.0 [1]
1-(3-Chlorophenyl)-2-(piperidin-1-yl)propan-1-oneIC5028.0 [1]
1-(3-Chlorophenyl)-2-(dimethylamino)propan-1-oneIC50100.0 [1]
3-(Tert-butylamino)-1-(3-chlorophenyl)-2-methylpropan-1-oneIC5016.0 [1]
1-(4-Bromophenyl)-2-(tert-butylamino)propan-1-oneIC507.6 [1]
2-(Tert-butylamino)-1-(3-chloro-4-methylphenyl)propan-1-oneIC505.7 [1]
2-(Tert-butylamino)-1-(3,5-dichlorophenyl)propan-1-oneIC5017.0 [1]
2-(Tert-butylamino)-1-(3,4-dichlorophenyl)butan-1-oneIC502.7 [1]
2-(N-Tert-Butylamino)-1-(2'-thienyl)-1-propanoneIC5069.0 [1]
2-(Tert-butylamino)-1-m-tolylpropan-1-oneIC5011.0 [1]
2-(Tert-butylamino)-1-(3,4-difluorophenyl)propan-1-oneIC5024.0 [1]
1-(4-Bromo-3-methylphenyl)-2-(tert-butylamino)propan-1-oneIC5012.0 [1]
1-(3-Chlorophenyl)-2-(cyclopentylamino)propan-1-oneIC50100.0 [1]
2-(Tert-butylamino)-1-(3,4-dichlorophenyl)pentan-1-oneIC501.5 [1]
2-(Tert-butylamino)-1-(3,4-dichlorophenyl)propan-1-oneIC509.8 [1]
2-(Tert-butylamino)-1-p-tolylpropan-1-oneIC5012.0 [1]
(2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-olIC50100000.0 [1]
(2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin-2-olIC5018000.0 [1]
(2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmorpholin-2-olIC5014000.0 [1]
(2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-morpholin-2-olIC5010000.0 [1]
(2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-olIC5057000.0 [1]
N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamideIC50100000.0 [1]
(R,R)-Hydroxy BupropionIC5028000.0 [1]
1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.1]heptane-7,3'-pyrrolidine]Ki580.0 [1]
1-(10-Azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl)ethanoneKi650.0 [1]
10-Azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-4-carbonitrileKi520.0 [1]
1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.2]octane-2,3'-pyrrolidine]Ki11000.0 [1]
1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.1]heptane-2,3'-pyrrolidine]Ki9900.0 [1]
3-Ethyl-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazoleIC509900.0 [1]
Methyl (1R,2S,3R,5S)-3-(3-fluoro-4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylateIC507300.0 [1]
5-[(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-3-(4-methoxyphenyl)-1,2-oxazoleIC5019000.0 [1]
DexmecamylamineIC50600.0 [1]
1-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-4-methyl-1,4-diazepaneIC5010000.0 [1]
2-[5-[5-(4-Methyl-1,4-diazepan-1-yl)pyridin-3-yl]-1,2-oxazol-3-yl]ethanolIC5010000.0 [1]
1-[5-[(1R,2S)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-1,4-diazepaneIC5010000.0 [1]
(1S,4S)-2-[5-[(1R,2S)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-2,5-diazabicyclo[2.2.1]heptaneIC5010000.0 [1]
(1S,4S)-2-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-2,5-diazabicyclo[2.2.1]heptaneIC5010000.0 [1]
1-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-1,4-diazepaneIC5010000.0 [1]
2-[5-[5-(1,4-Diazepan-1-yl)pyridin-3-yl]-1,2-oxazol-3-yl]ethanolIC5010000.0 [1]
N-[5-(4-Fluorophenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamideIC5030000.0 [1]
N-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]-5-morpholin-4-ylpentanamideIC5030000.0 [1]
N-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamideIC5031622.78 [1]
cis-1-Methyl-5-(phenylethynyl)-3-(piperidin-1-ylmethyl)pyrrolidin-2-oneIC5012589.25 [1]
(3R,5S)-5-[2-(1-Benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-oneIC50100000.0 [1]
(3R,5S)-1-Methyl-5-[2-(1-methylindol-5-yl)ethynyl]-3-(piperidin-1-ylmethyl)pyrrolidin-2-oneIC503981.07 [1]
(3R,5S)-5-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-oneIC506309.57 [1]
2-(Tert-butylamino)-1-(3-methoxyphenyl)propan-1-oneIC5016.0 [1]
2-(Tert-butylamino)-1-(3-nitrophenyl)propan-1-oneIC5041.0 [1]
2-(Cyclopentylamino)-1-(3-fluorophenyl)propan-1-oneIC5026.0 [1]
1-(3-Bromophenyl)-2-(cyclopentylamino)propan-1-oneIC506.5 [1]
2-(Cyclopentylamino)-1-(3-methylphenyl)propan-1-oneIC505.8 [1]
2-(Cyclopentylamino)-1-(3-methoxyphenyl)propan-1-oneIC509.2 [1]
2-(Cyclopentylamino)-1-(3-nitrophenyl)propan-1-oneIC5019.0 [1]
1-(3-Fluorophenyl)-2-piperidin-1-ylpropan-1-oneIC50100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/acetylcholine-receptor-alpha1-beta1-delta-gamma-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetylcholine-receptor-alpha1-beta1-delta-gamma-inhibitors-ic50-ki.
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