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Acetyl-coenzyme A transporter 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-[2-[4-[[4-[4-(1,2-Oxazol-3-yloxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.8 [1], 2.2 [2]
3-[2-[4-[[7-Butyl-4-[(2R,6S)-2,6-dimethyloxan-4-yl]-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.3 [1], 1.7 [2]
3-[2-[4-[[4-[4-(2-Hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.3 [1], 2.5 [2]
3-[2-[4-[[4-[4-(2-Hydroxypropoxy)cyclohexyl]-5-oxo-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.6 [1], 2.0 [2]
3-[2-[4-[[4-(3-Methyl-1-oxa-2-azaspiro[4.5]dec-2-en-8-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.7 [1]
3-[2-[4-[[4-[4-(4-Acetylphenoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1], 2.7 [2]
3-[2-[3-Fluoro-4-[[4-[3-(2-hydroxy-2-methylpropoxy)cyclobutyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1], 2.7 [2]
3-[2-[4-[[4-[2-(Hydroxymethyl)-1-oxaspiro[4.5]decan-8-yl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1], 3.1 [2]
3-[2-[4-[[4-[4-(4-Hydroxyphenoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1], 2.2 [2]
3-[2-[4-[[4-(1-Oxaspiro[4.5]decan-8-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.4 [1], 1.6 [2]
3-[2-[4-[[4-[4-(4-Methoxyphenoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.4 [1], 2.8 [2]
3-[2-[4-[[4-[4-(2-Hydroxyethoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.0 [1], 1.6 [2]
3-[2-[3-Fluoro-4-[[4-(4-hydroxycyclohexyl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC500.8 [1], 1.3 [2]
3-[2-[4-[[4-[4-(2-Hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.6 [1]
3-[2-[3-Fluoro-4-[[4-[4-(3-hydroxy-3-methylbutan-2-yl)oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[7-Butyl-4-[4-(2-hydroxy-2-methylpropoxy)cyclohexyl]-5-oxopyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[[4-[4-(3-Hydroxypropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[[4-[4-(2-Hydroxy-2-methylpropoxy)cyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]-2-methylphenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.6 [1]
3-[2-[4-[[7-Butyl-4-[4-(3-hydroxy-3-methylbutan-2-yl)oxycyclohexyl]-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[5-Oxo-4-[4-(2-oxopropoxy)cyclohexyl]-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[4-[4-[(1-Hydroxycyclopropyl)methoxy]cyclohexyl]-5-oxo-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[(4-Cyclohex-2-en-1-yl-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[3-Fluoro-4-[[4-[4-[4-fluoro-3-(fluoromethyl)-3-hydroxybutan-2-yl]oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.8 [1]
3-[2-[4-[[5-Oxo-7-propyl-4-[4-(3,3,3-trifluoro-2-hydroxy-2-methylpropoxy)cyclohexyl]-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[4-[(2E)-2-Methoxyiminopropoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.6 [1]
3-[2-[4-[[4-[(3E)-3-Ethoxyiminobutan-2-yl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[4-[[4-[4-[3-Fluoro-2-(fluoromethyl)-2-hydroxypropoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.4 [1]
3-[2-[3-Fluoro-4-[[4-[4-(2-hydroxy-2-methylpropoxy)cyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[4-[[4-(Oxan-4-yl)-5-oxo-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[4-[4-(3-Hydroxy-3-methylbutan-2-yl)oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[3-Fluoro-4-[[5-oxo-4-(4-propan-2-yloxyphenyl)-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[[4-[4-[[1-(Hydroxymethyl)cyclobutyl]methoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.5 [1]
3-[2-[3-Fluoro-4-[[4-[4-(2-hydroxy-2-methylpentan-3-yl)oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
2-[4-[6-[[2-Fluoro-4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]cyclohexyl]oxypropanenitrileIC502.5 [1]
3-[2-[4-[[4-[3-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[[4-[4-(Oxan-4-yloxyimino)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.5 [1]
3-[2-[4-[[7-Butyl-4-(2,2-dimethyloxan-4-yl)-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.3 [1]
3-[2-[4-[[4-(Oxan-3-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[4-[(1-Hydroxycyclobutyl)methoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.6 [1]
3-[2-[4-[[7-Butyl-2-methyl-4-(oxan-4-yl)-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]-3-fluorophenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC500.9 [1]
3-[2-[4-[[4-[4-(3,3-Difluoro-2-hydroxypropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.4 [1]
3-[2-[4-[[4-[4-(2-Hydroxypropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[7-Butyl-4-(2-methyloxan-4-yl)-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.2 [1]
3-[2-[4-[[4-[4-(5-Methyl-1,3,4-oxadiazol-2-yl)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[4-[[4-[4-(2-Hydroxy-2-methylpropoxy)cyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[4-[[4-(2,2-Dimethylpropyl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[3-Fluoro-4-[[4-[4-(2-hydroxy-2-methylpropoxy)-4-methylcyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
3-[2-[4-[[4-[4-(2-Hydroxy-2-methylpentan-3-yl)oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[(4-Fluorophenyl)methyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.6 [1]
3-[2-[4-[[5-Oxo-7-propyl-4-[4-(3,3,3-trifluoro-2-hydroxypropoxy)cyclohexyl]pyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[(3Ar,6aS)-spiro[3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-2,4'-cyclohexane]-1'-yl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.3 [1]
3-[2-[4-[(5-Oxo-4,7-dipropyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC503.0 [1]
3-[2-[4-[[4-(4-Hydroxy-4-methylcyclohexyl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.5 [1]
3-[2-[4-[[4-[4-(2-Hydroxypropan-2-yl)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.2 [1]
3-[2-[3-Fluoro-4-[[4-[4-[(1-hydroxycyclobutyl)methoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.4 [1]
3-[2-[3-Fluoro-4-[[4-(oxan-4-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.3 [1]
1-[[4-[5-Oxo-6-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]cyclohexyl]oxymethyl]cyclobutane-1-carbonitrileIC502.5 [1]
3-[2-[3-Fluoro-4-[[2-methyl-5-oxo-4-(oxolan-3-yl)-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[4-[[4-[4-(3-Methyl-1,2,4-oxadiazol-5-yl)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.4 [1]
3-[2-[4-[[5-Oxo-4-(4-prop-2-enoxycyclohexyl)-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[(2,4-Dimethoxyphenyl)methyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]-3-fluorophenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.5 [1]
3-[2-[4-[[2-Methyl-4-(6-methyloxan-3-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.4 [1]
3-[2-[4-[[4-[4-(2-Ethyl-2-hydroxybutoxy)cyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[4-[[4-[(4-Fluorophenyl)methyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[4-[[4-[4-(3-Fluoro-2-hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[(6-Ethylpyridin-3-yl)methyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.4 [1]
3-[2-[3-Fluoro-4-[[4-[4-(2-hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propylpyrazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[3-Fluoro-4-[[4-[4-[1-(1-hydroxycyclobutyl)ethoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[[4-(2,2-Dimethyloxan-4-yl)-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]-3-fluorophenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.3 [1]
3-[2-[4-[[5-Oxo-7-propyl-4-[4-(3,3,3-trifluoro-2-hydroxypropoxy)cyclohexyl]-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[4-[1-[4-[4-(2-Hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.9 [1]
3-[2-[3-Fluoro-4-[[2-methyl-4-(oxan-4-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.5 [1]
3-[2-[3-Fluoro-4-[[4-[3-(2-hydroxy-2-methylpropoxy)cyclobutyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.2 [1]
Ethyl 4-[5-oxo-6-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]cyclohexane-1-carboxylateIC501.4 [1]
3-[2-[4-[[4-(3,3-Dimethyl-2-oxo-1,4-dioxaspiro[4.5]decan-8-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC503.2 [1]
3-[2-[3-Fluoro-4-[[4-[4-[1-(2-hydroxypropan-2-yl)cyclopropyl]oxycyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.5 [1]
3-[2-[4-[[5-Oxo-4-(4-propan-2-yloxyiminocyclohexyl)-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.0 [1]
3-[2-[4-[[4-[4-[4-(2-Hydroxypropan-2-yl)phenoxy]cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-(3-Methoxy-2,2-dimethylpropyl)-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.5 [1]
3-[2-[4-[(4-Butan-2-yl-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.7 [1]
3-[2-[4-[[4-[4-(2-Hydroxyethoxy)-4-methylcyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.5 [1]
2-[4-[5-Oxo-6-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]cyclohexyl]oxypropanenitrileIC502.3 [1]
3-[2-[4-[[4-[4-Hydroxy-4-(methoxymethyl)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.8 [1]
3-[2-[4-[[4-[4-(Hydroxymethyl)-4-methylcyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC503.1 [1]
3-[2-[4-[[4-[3-(2-Ethyl-2-hydroxybutoxy)cyclobutyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.3 [1]
3-[2-[4-[[4-[4-(3-Hydroxybutan-2-yloxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.8 [1]
3-[2-[4-[[7-Butyl-4-(4-methoxycyclohexyl)-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[4-(3-Fluoro-2-hydroxy-2-methylpropoxy)cyclohexyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.2 [1]
3-[2-[4-[[4-(3-Methylidene-1,5-dioxaspiro[5.5]undecan-9-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC503.1 [1]
3-[2-[4-[[4-(1,4-Dioxaspiro[4.5]decan-8-yl)-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[4-(2-Hydroxybutoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.8 [1]
3-[2-[4-[[4-[1-(4-Hydroxyphenyl)piperidin-4-yl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.9 [1]
3-[2-[4-[[4-[4-(2-Ethyl-2-hydroxybutoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.3 [1]
3-[2-[4-[[7-Butyl-4-[4-(2-hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.1 [1]
3-[2-[4-[(4-Cyclohexyl-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.8 [1]
3-[2-[3-Fluoro-4-[[4-[4-(2-hydroxy-2-methylpropoxy)cyclohexyl]-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[3-Fluoro-4-[[4-(oxan-3-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-[(2E)-2-Ethoxyimino-3,3,3-trifluoropropyl]-2-methyl-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC501.9 [1]
3-[2-[4-[[4-(1-Benzylpiperidin-4-yl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC503.2 [1]
3-[2-[4-[[4-(4-Methoxycyclohexyl)-5-oxo-7-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-oneIC502.4 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetyl-coenzyme A transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/acetyl-coenzyme-a-transporter-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Acetyl-coenzyme A transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetyl-coenzyme-a-transporter-1-inhibitors-ic50-ki.
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