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Acetyl-CoA carboxylase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50126.0 [1]
1-[4-[4-[4-[2,6-Bis(4-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5076.0 [1]
(3R)-1'-(9-Anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidineIC50116.0 [1]
1-[4-[4-[4-[2,6-Bis(4-hydroxyphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5052.0 [1]
1-[4-[4-[4-[2-(4-Hydroxyphenyl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5047.0 [1]
1-[4-[4-[4-[2,6-Bis(4-methoxyphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5068.0 [1]
1-[4-[4-[4-[2,6-Bis[4-(hydroxymethyl)phenyl]pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5032.0 [1]
Tert-butyl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5024.0 [1]
1-[3-[4-(1-Acetylpiperidin-4-yl)piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC501864.0 [1]
(2,6-Diphenylpyridin-4-yl)-[4-[1-(morpholine-4-carbonyl)piperidin-4-yl]piperazin-1-yl]methanoneIC50869.0 [1]
(2,6-Diphenylpyridin-4-yl)-[4-[1-(piperidine-1-carbonyl)piperidin-4-yl]piperazin-1-yl]methanoneIC50434.0 [1]
[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]-phenylmethanoneIC50693.0 [1]
Cyclohexyl-[4-[4-(2,6-diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]methanoneIC50244.0 [1]
[4-[1-(2,5-Dimethylfuran-3-carbonyl)piperidin-4-yl]piperazin-1-yl]-(2,6-diphenylpyridin-4-yl)methanoneIC50157.0 [1]
[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]-(4-methoxycyclohexyl)methanoneIC50155.0 [1]
1-[4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]propan-1-oneIC50115.0 [1]
(1-Benzoylpiperidin-4-yl)-[4-[4-(2,6-diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]methanoneIC50290.0 [1]
1-[4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]-2-methoxyethanoneIC50169.0 [1]
1-[4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]-2-hydroxyethanoneIC50102.0 [1]
Methyl 4-[4-[4-(2,6-diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidine-1-carboxylateIC50102.0 [1]
Propan-2-yl 4-[4-[4-(2,6-diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidine-1-carboxylateIC50411.0 [1]
4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]piperidine-1-carboxamideIC50151.0 [1]
4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]-N-methylpiperidine-1-carboxamideIC5095.0 [1]
4-[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidine-1-carbonyl]-N,N-dimethylpiperidine-1-carboxamideIC50169.0 [1]
[4-[4-(2,6-Diphenylpyridine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanoneIC50248.0 [1]
1-[4-[4-[4-[2,6-Bis(3-fluorophenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50131.0 [1]
1-[4-[4-[4-[2-(4-Fluorophenyl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50184.0 [1]
3-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-(3-carbamoylphenyl)pyridin-2-yl]benzamideIC5073.0 [1]
4-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-(4-carbamoylphenyl)pyridin-2-yl]benzamideIC5067.0 [1]
Anthracen-9-yl-[4-[1-(morpholine-4-carbonyl)piperidin-4-yl]piperazin-1-yl]methanoneIC50239.0 [1]
Anthracen-9-yl-[4-[1-(piperidine-1-carbonyl)piperidin-4-yl]piperazin-1-yl]methanoneIC50121.0 [1]
[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-phenylmethanoneIC5066.0 [1]
1-[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-2-phenylethanoneIC502112.0 [1]
[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-cyclohexylmethanoneIC5091.0 [1]
[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-cyclopentylmethanoneIC5095.0 [1]
[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-(furan-2-yl)methanoneIC50161.0 [1]
[4-[4-(Anthracene-9-carbonyl)piperazin-1-yl]piperidin-1-yl]-(2,5-dimethylfuran-3-yl)methanoneIC5060.0 [1]
5-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrileIC509.7 [1]
1-[4-[4-[4-[2-[2-[(Dimethylamino)methyl]-3-methyl-1H-indol-5-yl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC508.4 [1]
1-[4-[4-[4-[2-(1,3-Dimethylindol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50127.0 [1]
1-[4-[4-[4-[2-(2,3-Dimethyl-1H-indol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5033.0 [1]
1-[4-[4-[4-[2-Phenyl-6-(1,2,3-trimethylindol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50105.0 [1]
1-[4-[4-[4-[2-(3-Ethyl-2-methyl-1H-indol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50169.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5072.0 [1]
1-[4-[4-[4-[2-(3-Fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5049.0 [1]
1-[4-[4-[4-[2-(3-Fluoro-4-methoxyphenyl)-6-(1H-indazol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5061.0 [1]
1-[4-[4-[4-[2-(3,4-Dimethoxyphenyl)-6-(1H-indazol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5030.0 [1]
1-[4-[4-[4-[2-(1-Methylindol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5069.0 [1]
1-[4-[4-[4-[2-(2-Methyl-1H-indol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5059.0 [1]
1-[4-[4-[4-[2-(3-Methyl-1H-indol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5036.0 [1]
1-[4-[4-[4-[2-(1,2-Dimethylindol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50117.0 [1]
1-[4-[4-[4-[2-(1H-Indazol-6-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5057.0 [1]
5-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydroindol-2-oneIC5054.0 [1]
1-[4-[4-[4-[2-(3-Fluorophenyl)-6-(1H-indol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5033.0 [1]
1-[4-[4-[4-[2-(4-Fluorophenyl)-6-(1H-indol-5-yl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5048.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-(3-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5037.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-(4-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5030.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-(3-methoxyphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5032.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-(4-methoxyphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5021.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50100.0 [1]
4-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-phenylpyridin-2-yl]benzamideIC5080.0 [1]
1-[4-[4-[4-[2-[4-(2-Hydroxyethyl)phenyl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5027.0 [1]
2-[4-[4-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-6-phenylpyridin-2-yl]phenyl]acetic acidIC5075.0 [1]
1-[4-[4-[4-[2-[4-(2-Hydroxyethoxy)phenyl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5047.0 [1]
1-[4-[4-[4-[2-[4-(3-Hydroxypropyl)phenyl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5070.0 [1]
1-[4-[4-[4-[2-(1H-Indol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5055.0 [1]
1-[4-[4-[4-[2-(1H-Indol-6-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5047.0 [1]
1-[4-[4-[4-[2-(1H-Indazol-5-yl)-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5042.0 [1]
1-[4-[4-[4-[2-[3-(Hydroxymethyl)phenyl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5047.0 [1]
1-[4-[4-[4-[2-[4-(Hydroxymethyl)phenyl]-6-phenylpyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5042.0 [1]
Ethyl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5055.0 [1]
N-Tert-butyl-4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxamideIC50119.0 [1]
(1,1,1-Trifluoro-2-methylpropan-2-yl) 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5031.0 [1]
1-Ethyl-3-[6-methyl-3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC5058.0 [1]
1-Ethyl-3-[3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]thieno[3,2-c]pyridin-2-yl]ureaIC50117.0 [1]
(1-Fluoro-2-methylpropan-2-yl) 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5017.0 [1]
1-Ethyl-3-[3-[4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC50131.0 [1]
1-Ethyl-3-[5-methyl-3-[4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC5032.0 [1]
Methyl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC50175.0 [1]
1-[4-[4-[4-[2-(2,3-Dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5033.0 [1]
1-Ethyl-3-[3-[4-(1-pentanoylpiperidin-4-yl)piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC50207.0 [1]
Cyclopentyl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5052.0 [1]
Cyclohexyl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5076.0 [1]
1-Ethyl-3-[3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-6-(trifluoromethyl)-1-benzothiophen-2-yl]ureaIC5098.0 [1]
1-Ethyl-3-[3-[4-[1-(3-fluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-6-methyl-1-benzothiophen-2-yl]ureaIC5032.0 [1]
1-Ethyl-3-[6-fluoro-3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC5062.0 [1]
1-Ethyl-3-[6-methyl-3-[4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC5060.0 [1]
1-Ethyl-3-[3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]thieno[3,2-b]pyridin-2-yl]ureaIC5012.0 [1]
1-Ethyl-3-[3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]thieno[2,3-c]pyridin-2-yl]ureaIC5041.0 [1]
1-Ethyl-3-[3-[4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC50144.0 [1]
1-Ethyl-3-[3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]thieno[2,3-b]pyridin-2-yl]ureaIC5045.0 [1]
1-[3-[4-[1-(Cyclohexanecarbonyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5081.0 [1]
Propan-2-yl 4-[4-[2-(ethylcarbamoylamino)-1-benzothiophene-3-carbonyl]piperazin-1-yl]piperidine-1-carboxylateIC5028.0 [1]
1-[3-[4-[1-(2,2-Dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC50109.0 [1]
1-[6-Chloro-3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5038.0 [1]
1-[3-[4-(1-Butanoylpiperidin-4-yl)piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC50242.0 [1]
1-Ethyl-3-[6-methoxy-3-[4-[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC5027.0 [1]
1-Ethyl-3-[3-[4-(1-propanoylpiperidin-4-yl)piperazine-1-carbonyl]-1-benzothiophen-2-yl]ureaIC50597.0 [1]
(Z)-But-2-enedioic acid;1-[3-[4-[1-(cyclopentanecarbonyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5049.0 [1]
1-[3-[4-[1-(1-Acetylpiperidine-4-carbonyl)piperidin-4-yl]piperazine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylurea;(Z)-but-2-enedioic acidIC5074.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetyl-CoA carboxylase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Acetyl-CoA carboxylase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-inhibitors-ic50-ki.
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