7,8-dihydro-8-oxoguanine triphosphatase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine	IC50	5.0 [1], 7.0 [2], 10.0 [3]
	6-(2,3-Dichlorophenyl)-N~4~-Methylpyrimidine-2,4-Diamine	IC50	0.8 [1], 0.9 [2], 1.6 [3]
	(S)-Crizotinib	IC50	330.0 [1], 408.0 [2]
	Ras/Rac Transformation Blocker, SCH 51344	IC50	410.0 [1]
	N8,N8-Dimethyl-9H-purine-6,8-diamine	IC50	3500.0 [1]
	8-(Methylthio)-9H-purin-6-amine	IC50	24000.0 [1]
	4-Methylquinazolin-2-amine	IC50	5600.0 [1]
	6-Phenethylsulfanyl-7H-purin-2-amine	IC50	170.0 [1]
	N-Ethyl-4-[(3S)-3-methylmorpholin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.8 [1]
	Imidazo[1,2-a]pyrazin-8-amine	IC50	26000.0 [1]
	6-N-(2-Phenylethyl)-7H-purine-2,6-diamine	IC50	100.0 [1]
	6-(3,4-Dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	100000.0 [1]
	3-[(2-Amino-5-methylpyrimidin-4-yl)amino]-2,2-dimethylpropan-1-ol	IC50	3.1 [1]
	3-[(2-Aminopyrimidin-4-yl)amino]-2,2-dimethylpropan-1-ol	IC50	332.0 [1]
	17-(Methylamino)-8,11,14-trioxa-1,16,19,22-tetrazatetracyclo[13.5.2.13,7.018,21]tricosa-3(23),4,6,15,17,21-hexaen-20-one	IC50	0.5 [1]
	2-[4-(2-Aminoquinazolin-4-Yl)phenyl]-N,N-Dimethyl-Acetamide	IC50	9.0 [1]
	4-(3,3-Dimethylbutyl)-5-methylpyrimidin-2-amine	IC50	1.8 [1]
	4-(2,2-Dimethylpropoxy)-5-methylpyrimidin-2-amine	IC50	0.2 [1]
	3-(2-Amino-5-methylpyrimidin-4-yl)oxy-2,2-dimethylpropan-1-ol	IC50	0.6 [1]
	3-[(2-Amino-5-methylpyrimidin-4-yl)-methylamino]-2,2-dimethylpropan-1-ol	IC50	0.5 [1]
	[1-[(2-Aminopyrimidin-4-yl)oxymethyl]cyclopropyl]methanol	IC50	850.0 [1]
	3-(2-Amino-6-methylpyrimidin-4-yl)oxy-2,2-dimethylpropan-1-ol	IC50	302.0 [1]
	3-(2-Amino-5-methoxypyrimidin-4-yl)oxy-2,2-dimethylpropan-1-ol	IC50	10.0 [1]
	3-(2-Amino-5-chloropyrimidin-4-yl)oxy-2,2-dimethylpropan-1-ol	IC50	22.0 [1]
	4-(2,2-Dimethylpropoxy)pyrimidin-2-amine	IC50	53.0 [1]
	4-N-(3-Methoxy-2,2-dimethylpropyl)pyrimidine-2,4-diamine	IC50	120.0 [1]
	3-[(2-Amino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy]-2,2-dimethylpropan-1-ol	IC50	4.5 [1]
	4-Anilino-6,7-dimethoxy-N-methylquinoline-3-carboxamide	IC50	0.5 [1]
	4-(3-Chlorophenyl)-N-ethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	20.0 [1]
	N-Ethyl-4-[2-(2-methoxypropan-2-yl)pyrrolidin-1-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	5-[4-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,3-oxazole	IC50	10000.0 [1]
	[4-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]methanol	IC50	1400.0 [1]
	4-(2-Pyridin-3-ylpyrrolidin-1-yl)-1H-pyrazolo[3,4-b]pyridine	IC50	30.0 [1]
	4-(3-Chlorophenyl)-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	2700.0 [1]
	2-Phenyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)morpholine	IC50	700.0 [1]
	N-Ethyl-4-(2-pyridin-3-ylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(2-Phenylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	5.0 [1]
	4-(3-Cyclopropylmorpholin-4-yl)-N-ethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(2,3-Dihydropyrrolo[2,3-b]pyridin-1-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	300.0 [1]
	4-(2-Phenylpyrrolidin-1-yl)-1H-pyrazolo[3,4-b]pyridine	IC50	1.0 [1]
	N-Cyclopropyl-4-(2-pyridin-2-ylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	2500.0 [1]
	4-[2-(2-Methoxypropan-2-yl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine	IC50	5.0 [1]
	4-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carbonitrile	IC50	5600.0 [1]
	5-Methyl-7-phenyl-1,3-benzoxazol-2-amine	IC50	120.0 [1]
	N-(Oxetan-3-yl)-4-(2-pyridin-3-ylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	N-Ethyl-4-(3-phenylmorpholin-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(3-Chlorophenyl)-2-methyl-1H-pyrrolo[2,3-b]pyridine	IC50	10000.0 [1]
	4-(3-Chlorophenyl)-N-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	12.0 [1]
	N-Methyl-4-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	200.0 [1]
	4-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-2,3-dihydro-1,4-benzoxazine	IC50	40.0 [1]
	3-Phenyl-4-(1H-pyrazolo[3,4-b]pyridin-4-yl)morpholine	IC50	2.0 [1]
	4-(3-Chlorophenyl)-N-cyclopropyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	10.0 [1]
	N-(Oxetan-3-yl)-4-(2-pyridin-2-ylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	5800.0 [1]
	N-Ethyl-4-(2-phenylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	4-(3-Chlorophenyl)-1H-pyrazolo[3,4-b]pyridine	IC50	3000.0 [1]
	N-Ethyl-4-(2-pyridin-2-ylpyrrolidin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide	IC50	0.1 [1]
	6-(1,3,3-Trimethyl-6-azabicyclo[3.2.1]oct-6-yl)-9H-purine	IC50	100.0 [1]
	1H-Pyrrolo[2,3-b]pyridine, 4-(3-pyridinyl)-	IC50	3700.0 [1]
	8-Methyl-6-methylsulfanyl-7H-purin-2-amine	IC50	79000.0 [1]
	5,7-Dimethyl-1,3-benzoxazol-2-amine	IC50	23000.0 [1]
	Ethyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate	IC50	9900.0 [1]
	4-(2,2-Dimethylpropoxy)-6-methylpyrimidin-2-amine	IC50	112.0 [1]
	4-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	1900.0 [1]
	2-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-3,4-dihydro-1H-isoquinoline	IC50	200.0 [1]
	3-[(2-Aminopyrimidin-4-yl)amino]propan-1-ol	IC50	2980.0 [1]
	4-N-(2,2-Dimethylpropyl)pyrimidine-2,4-diamine	IC50	84.0 [1]
	4-N-(2,2-Dimethylpropyl)-5-methylpyrimidine-2,4-diamine	IC50	0.5 [1]
	4-N-(2,2-Dimethylpropyl)-4-N,5-dimethylpyrimidine-2,4-diamine	IC50	0.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 70 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 7,8-dihydro-8-oxoguanine triphosphatase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/7-8-dihydro-8-oxoguanine-triphosphatase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ 7,8-dihydro-8-oxoguanine triphosphatase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/7-8-dihydro-8-oxoguanine-triphosphatase-inhibitors-ic50-ki.
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