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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-oneIC5022900.0 [1], 25000.0 [2], 100000.0 [3]
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-oneKi25100.0 [1]
2-Amino-N-[4-(2-amino-3-cyano-1-ethylindol-5-yl)oxyphenyl]acetamideIC50514.0 [1], 30000.0 [2]
2-Amino-N-[4-[2-amino-3-cyano-1-[2-(dimethylamino)-2-oxoethyl]indol-5-yl]oxyphenyl]acetamideIC50343.0 [1], 30000.0 [2]
(2s)-2-Amino-N-[4-[(2-Amino-3-Cyano-1h-Indol-5-Yl)oxy]phenyl]-3-Hydroxy-PropanamideIC50575.0 [1], 30000.0 [2]
(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]-methylamino]phenyl]pyrrolidine-2-carboxamideIC5075.0 [1], 13700.0 [2], 30000.0 [3]
(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indol-5-yl]sulfonylphenyl]pyrrolidine-2-carboxamideIC5024700.0 [1], 30000.0 [2], 37700.0 [3]
(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]methyl]phenyl]pyrrolidine-2-carboxamideIC50199.0 [1], 30000.0 [2]
AZ Pfkfb3 26IC5023.0 [1], 343.0 [2], 5770.0 [3]
2-Amino-N-[4-[2-amino-3-cyano-1-(2-methylpropyl)indol-5-yl]oxyphenyl]acetamideIC50177.0 [1], 16400.0 [2], 30000.0 [3]
(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamideIC50112.0 [1], 3050.0 [2], 12000.0 [3]
(2S)-N-[4-[3-Cyano-1-[2-(methylamino)-2-oxoethyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC50111.0 [1], 14000.0 [2], 30000.0 [3]
(2S)-N-[4-[3-Cyano-1-[2-(dimethylamino)ethyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC50256.0 [1], 7480.0 [2], 30000.0 [3]
(2S)-N-[4-[3-Cyano-1-(oxan-4-ylmethyl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC5048.0 [1], 633.0 [2], 30000.0 [3]
(2S)-N-[4-[3-Cyano-1-(2-methyl-1-oxo-3H-isoindol-5-yl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC508.0 [1], 140.0 [2], 2180.0 [3]
(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indazol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC504.0 [1], 297.0 [2], 15400.0 [3]
2-Amino-N-[4-[[3-(1-methylpyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]acetamideIC50496.0 [1], 30000.0 [2]
(2S)-N-[4-[[3-(1-Methylpyrazol-4-yl)-1H-indol-5-yl]oxy]phenyl]pyrrolidine-2-carboxamideIC50114.0 [1], 30000.0 [2]
2-Amino-N-[4-(2-Amino-1-Benzyl-3-Cyano-Indol-5-Yl)oxyphenyl]acetamideIC50104.0 [1], 12600.0 [2], 30000.0 [3]
CID 91668554IC5011.0 [1], 281.0 [2], 30000.0 [3]
(2s)-N-[4-[1-Methyl-3-(1-Methylpyrazol-4-Yl)indol-5-Yl]oxyphenyl]pyrrolidine-2-CarboxamideIC5021.0 [1], 979.0 [2], 9710.0 [3]
5,6,7,8,4'-PentahydroxyflavoneIC502970.0 [1]
5,6,7,8,4'-PentahydroxyflavoneKi1290.0 [1]
1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-oneIC50207.0 [1], 1000000.0 [2]
2-Amino-N-[4-(2-amino-3-cyano-1-methylindol-5-yl)oxyphenyl]acetamideIC50815.0 [1], 30000.0 [2]
2-Amino-N-[4-(3-cyano-1-ethylindol-5-yl)oxyphenyl]acetamideIC50562.0 [1], 30000.0 [2]
5-(4-Acetyl-5-methyltriazol-1-yl)-4-bromo-2-phenylpyridazin-3-oneIC507400.0 [1]
(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]amino]phenyl]pyrrolidine-2-carboxamideIC501570.0 [1], 30000.0 [2]
(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indol-5-yl]sulfanylphenyl]pyrrolidine-2-carboxamideIC50111.0 [1], 14000.0 [2]
N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-2-(methylamino)acetamideIC50830.0 [1], 30000.0 [2]
N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-2-(dimethylamino)acetamideIC509830.0 [1], 30000.0 [2]
(2R)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamideIC5030000.0 [1], 70900.0 [2]
(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-N-methylpyrrolidine-2-carboxamideIC5023100.0 [1], 30000.0 [2]
(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]azetidine-2-carboxamideIC5086.0 [1], 19600.0 [2]
(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]piperidine-2-carboxamideIC502200.0 [1], 30000.0 [2]
(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-N-methyl-5-oxopyrrolidine-2-carboxamideIC50531.0 [1], 30000.0 [2]
(2S)-N-[4-(3-Cyano-1-phenylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamideIC5027.0 [1], 8710.0 [2]
(2S)-N-[4-(1-Benzyl-3-cyanoindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamideIC5020.0 [1], 6950.0 [2]
(2S)-N-[4-[3-Cyano-1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]indazol-5-yl]oxyphenyl]pyrrolidine-2-carboxamideIC503.0 [1], 67.0 [2]
2-Hydroxy-4-(naphthalen-1-ylsulfonylamino)benzoic acidIC50490.0 [1], 27000.0 [2]
6-(2-Chloro-3-methoxyphenyl)-N-[1-[3-[(2,5-dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(2-pyrazol-1-ylethoxy)phenyl]ethyl]pyrimidin-4-amineIC50500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]ethyl]pyrimidin-4-amineIC500.0 [1], 500.0 [2]
N-[1-[3-(Furan-3-yl)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1], 500.0 [2]
N-[1-[3-[3-(Dimethylamino)propoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
4-[2-Methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]benzamideIC500.0 [1]
Methyl 2-[[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]methyl]-1,3-oxazole-4-carboxylateIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[1-[5-[(2,5-dimethylpyrazol-3-yl)methoxy]pyridin-3-yl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1]
N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
N-[1-(2-Fluorophenyl)ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
1-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]-3-carbamoylureaIC50500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(6-fluoro-2-methylpyridin-3-yl)phenyl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1], 500.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(methylsulfonylmethoxy)phenyl]ethyl]pyrimidin-4-amineIC500.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-thiophen-3-ylphenyl)ethyl]pyrimidin-4-amineIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[1-(3-bromophenyl)ethyl]-2-methylpyrimidin-4-amineIC500.0 [1], 500.0 [2]
[3-[[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]methyl]piperidin-1-yl]-cyclopentylmethanoneIC50500.0 [1], 1000.0 [2]
Tert-butyl 3-[[3-[1-[[2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-yl]amino]ethyl]phenoxy]methyl]piperidine-1-carboxylateIC50500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(3-methyl-1,2-oxazol-5-yl)methoxy]phenyl]ethyl]pyrimidin-4-amineIC500.0 [1]
3-[1-[[6-(2-Fluoro-3-methoxyphenyl)-2-methylpyrimidin-4-yl]amino]ethyl]phenolIC501000.0 [1]
N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-6-(3-ethyl-1-benzofuran-5-yl)-2-methylpyrimidin-4-amineIC500.0 [1], 1000.0 [2]
[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]ureaIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(2-fluoropyrimidin-5-yl)phenyl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1]
N-[1-[3-(2-Imidazol-1-ylethoxy)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]-N-but-2-ynylbenzenesulfonamideIC500.0 [1]
Methyl 2-[3-[[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]methyl]-4-fluorophenoxy]acetateIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[[3-[(4-methylphenoxy)methyl]-1,2,4-oxadiazol-5-yl]methoxy]phenyl]ethyl]pyrimidin-4-amineIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-nitrophenyl)ethyl]pyrimidin-4-amineIC50500.0 [1]
N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-6-(3-methoxy-4-methylphenyl)-2-methylpyrimidin-4-amineIC500.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(2-methylsulfonylethoxy)phenyl]ethyl]pyrimidin-4-amineIC501000.0 [1]
N-[5-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]pyrimidin-2-yl]-N',N'-dimethylethane-1,2-diamineIC500.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(2-imidazol-1-ylethoxy)phenyl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1]
Ethyl 5-[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]pyridine-3-carboxylateIC50500.0 [1], 1000.0 [2]
N-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]-1-methylimidazole-4-sulfonamideIC501000.0 [1]
2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-1-pyrrolidin-1-ylethanoneIC50500.0 [1], 1000.0 [2]
2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-N-[2-(dimethylamino)ethyl]acetamideIC500.0 [1], 500.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(1H-pyrazol-5-ylmethoxy)phenyl]ethyl]pyrimidin-4-amineIC500.0 [1], 500.0 [2]
2-Methoxy-4-[2-methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]benzamideIC500.0 [1]
2-Methyl-6-(3-methyl-1-benzofuran-5-yl)-N-[1-(3-methylphenyl)ethyl]pyrimidin-4-amineIC500.0 [1], 500.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-prop-2-ynoxyphenyl)ethyl]pyrimidin-4-amineIC50500.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[(2-fluorophenyl)methyl]-2-methylpyrimidin-4-amineIC50500.0 [1], 1000.0 [2]
2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-N-(2-hydroxypropyl)acetamideIC50500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(5-methyl-1,2-oxazol-3-yl)methoxy]phenyl]ethyl]pyrimidin-4-amineIC50500.0 [1]
2-[3-[1-[[2-Methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-yl]amino]ethyl]phenoxy]-1-morpholin-4-ylethanoneIC500.0 [1]
2-Methyl-6-(3-methyl-1-benzofuran-5-yl)-N-[1-(2-methylphenyl)ethyl]pyrimidin-4-amineIC501000.0 [1]
4-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]butan-1-olIC500.0 [1]
6-(1-Ethylindol-6-yl)-2-methyl-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrimidin-4-amineIC500.0 [1]
3-[1-[[6-(3-Ethyl-1-benzofuran-5-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenolIC500.0 [1], 1000.0 [2]
N-[1-[3-(2-Aminopyrimidin-5-yl)-4-fluorophenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
6-(1,3-Benzothiazol-6-yl)-N-[1-(2-methoxypyridin-4-yl)ethyl]-2-methylpyrimidin-4-amineIC50500.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-propoxyphenyl)ethyl]pyrimidin-4-amineIC500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-N-[1-[3-[2-(dimethylamino)ethoxy]phenyl]ethyl]-2-methylpyrimidin-4-amineIC500.0 [1], 500.0 [2]
Methyl 2-[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]acetateIC501000.0 [1]
6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(1-methylpiperidin-3-yl)methoxy]phenyl]ethyl]pyrimidin-4-amineIC500.0 [1]
N,N-Diethyl-2-[3-[1-[[6-(2-fluoro-3-methoxyphenyl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]acetamideIC501000.0 [1]
N-[1-[2-(2-Aminopyrimidin-5-yl)pyridin-4-yl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
N-[(1S)-1-[3-(6-Chloropyridin-3-yl)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
N-[1-[3-[2-(Dimethylamino)ethoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1], 1000.0 [2]
6-(1,3-Benzothiazol-6-yl)-N-[(2-chloro-6-fluorophenyl)methyl]-2-methylpyrimidin-4-amineIC500.0 [1]
2-[2-Methyl-5-[2-methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]phenoxy]acetonitrileIC500.0 [1]
N-[(1S)-1-(4-Methoxyphenyl)ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amineIC500.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/6-phosphofructo-2-kinase-fructose-2-6-bisphosphatase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/6-phosphofructo-2-kinase-fructose-2-6-bisphosphatase-3-inhibitors-ic50-ki.
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