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6-O-methylguanine-DNA methyltransferase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
o6-BenzylguanineIC5039.0 [1], 180.0 [2], 620.0 [3], 2600.0 [4]
O6-AllylguanineIC502700.0 [1], 5100.0 [2], 8500.0 [3]
2-Amino-6-methoxypurineIC50248000.0 [1], 428000.0 [2]
LomeguatribIC503.0 [1], 9.0 [2]
9H-Purin-2-amine, 6-(2-propyn-1-yloxy)-IC5011900.0 [1], 20000.0 [2]
9H-Purin-2-amine, 6-[(2-methyl-2-propen-1-yl)oxy]-IC509900.0 [1], 25000.0 [2]
O6-Substituted Guanine Deriv. 19IC5039600.0 [1], 77000.0 [2]
O6-Substituted Guanine Deriv. 21IC50119000.0 [1], 192000.0 [2]
9H-Purin-2-amine, 6-(1-cyclopenten-1-ylmethoxy)-IC50200.0 [1], 390.0 [2]
2-Butanone, 1-[(2-amino-9H-purin-6-yl)oxy]-IC5093200.0 [1], 151000.0 [2]
6-[(1-Oxidopyridin-1-ium-3-yl)methoxy]-6,7-dihydro-3H-purin-2-amineIC501400.0 [1], 5400.0 [2]
6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC50120.0 [1], 200.0 [2]
6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC5033.0 [1], 60.0 [2]
6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC5070.0 [1]
6-(Pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC50130.0 [1], 200.0 [2]
6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC5040.0 [1], 50.0 [2]
6-(5-Bromo-pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC50200.0 [1], 250.0 [2]
6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,7-dihydro-3H-purin-2-amineIC5090.0 [1], 230.0 [2]
6-(Pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC50220.0 [1], 430.0 [2]
6-(Pyridin-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC506000.0 [1], 35000.0 [2]
6-[(3-Methylimidazol-4-yl)methoxy]-6,7-dihydro-3H-purin-2-amineIC508500.0 [1], 21000.0 [2]
6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC5080.0 [1], 120.0 [2]
6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC505.0 [1], 10.0 [2]
6-(Oxazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC50220.0 [1], 350.0 [2]
6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamineIC5018.0 [1], 30.0 [2]
6-EthylguanineIC501000000.0 [1]
6-O-Cyclohexylmethyl guanineIC501000000.0 [1]
6-Butoxy-9H-purin-2-amineIC50493000.0 [1]
2,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)-IC50130.0 [1]
Purine, 2-amino-6-propoxy-IC501000000.0 [1]
6-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-9H-purin-2-ylamineIC501000000.0 [1]
6-[[3-(Aminomethyl)phenyl]methoxy]-7H-purin-2-amineIC509.0 [1]
6-(4-Isopropenyl-cyclohex-1-enylmethoxy)-9H-purin-2-ylamineIC502600.0 [1]
1-[(2-Amino-6,9-dihydro-1H-purin-6-YL)oxy]-3-methyl-2-butanolIC501000000.0 [1]
6-Pentoxy-7H-purin-2-amineIC501006000.0 [1]
9H-Purin-2-amine, 6-(heptyloxy)-IC50100000.0 [1]
O6-Substituted Guanine Deriv. 11IC501000000.0 [1]
O6-Substituted Guanine Deriv. 17IC5016000.0 [1]
O6-Substituted Guanine Deriv. 18IC501000000.0 [1]
6-(Cyclopentylmethoxy)-9H-purin-2-amineIC501000000.0 [1]
9H-Purin-2-amine, 6-(1-cyclohexen-1-ylmethoxy)-IC501600.0 [1]
9H-Purin-2-amine, 6-(3-cyclohexen-1-ylmethoxy)-IC501000000.0 [1]
O6-Substituted Guanine Deriv. 36IC50548000.0 [1]
O6-Substituted Guanine Deriv. 42IC501000000.0 [1]
2,6-Diamino-4-benzyloxypyrimidineIC50170000.0 [1]
O6-Substituted Guanine Deriv. 41IC501000000.0 [1]
7-Benzyloxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamineIC5038.0 [1]
6-[[3-[(Dimethylamino)methyl]phenyl]methoxy]-7H-purin-2-amineIC5025.0 [1]
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamineIC501300.0 [1]
5-Nitroso-6-(4-fluorobenzyloxy)pyrimidine-2,4-diamineIC5051.0 [1]
6-Hex-3-enyloxy-9H-purin-2-ylamineIC501000000.0 [1]
6-(1-Cyclobutenylmethoxy)-9H-purine-2-amineIC50550.0 [1]
5-Nitro-6-(2-pyridinylmethoxy)pyrimidine-2,4-diamineIC5018000.0 [1]
5-Nitroso-6-(4-pyridinylmethoxy)pyrimidine-2,4-diamineIC50230.0 [1]
5-Nitro-6-(4-pyridinylmethoxy)pyrimidine-2,4-diamineIC501900.0 [1]
6-(2,2-Dimethoxy-2-phenyl-ethoxy)-9H-purin-2-ylamineIC501000000.0 [1]
2-(2-Amino-9H-purin-6-yloxy)-1-phenyl-ethanoneIC501000000.0 [1]
6-Hexyloxy-9H-purin-2-ylamineIC50554000.0 [1]
5-Nitro-6-(2-fluorobenzyloxy)pyrimidine-2,4-diamineIC5012000.0 [1]
6-Cyclobutylmethoxy-9H-purin-2-ylamineIC501000000.0 [1]
5-Nitro-6-(4-fluorobenzyloxy)pyrimidine-2,4-diamineIC50350.0 [1]
5-Nitro-6-(3-pyridinylmethoxy)pyrimidine-2,4-diamineIC501600.0 [1]
5-Nitro-6-(3-fluorobenzyloxy)pyrimidine-2,4-diamineIC502500.0 [1]
(2S,4R,5S)-2-[6-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]hexoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50450.0 [1]
6-(2-Thienyloxy)-9H-purine-2-amineIC503.0 [1]
(2S,4R,5S)-2-[8-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC5032.0 [1]
(2R,4S,5R)-2-[2-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50680.0 [1]
(2R,4S,5R)-2-[2-(2-Amino-6-phenylmethoxypurin-9-yl)ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC5025000.0 [1]
(2S,4R,5S)-2-[10-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]decoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC5030.0 [1]
(2S,4R,5S)-2-[12-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]dodecoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC5030.0 [1]
(2S,4R,5S)-2-[4-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]but-2-ynoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50250.0 [1]
(2S,4R,5S)-2-[4-[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]butoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50450.0 [1]
(2R,4S,5R)-2-[2-(5-Amino-7-phenylmethoxytriazolo[4,5-d]pyrimidin-3-yl)ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC502000.0 [1]
2-Amino-4-(4-bromothenyloxy)-6-morpholino-5-nitropyrimidineIC501000.0 [1]
4-N-[4-(4-Aminoanilino)phenyl]-6-[(4-bromothiophen-2-yl)methoxy]-5-nitropyrimidine-2,4-diamineIC504700.0 [1]
2-Amino-4-benzyloxy-6-morpholino-5-nitropyrimidineIC5019000.0 [1]
4-N-[4-(4-Aminophenoxy)phenyl]-5-nitro-6-phenylmethoxypyrimidine-2,4-diamineIC50600000.0 [1]
4-N-[4-[(4-Aminophenyl)methyl]phenyl]-6-[(4-bromothiophen-2-yl)methoxy]-5-nitropyrimidine-2,4-diamineIC5020000.0 [1]
[4-[[2-Amino-6-[(4-bromothiophen-2-yl)methoxy]-5-nitropyrimidin-4-yl]amino]phenyl]-(4-aminophenyl)methanoneIC505700.0 [1]
4-N-[4-(4-Aminophenoxy)phenyl]-6-[(4-bromothiophen-2-yl)methoxy]-5-nitropyrimidine-2,4-diamineIC5013000.0 [1]
[4-[(2-Amino-5-nitro-6-phenylmethoxypyrimidin-4-yl)amino]phenyl]-(4-aminophenyl)methanoneIC50600000.0 [1]
6-((4-Bromothiophen-2-yl)methoxy)-5-nitropyrimidine-2,4-diamineIC50320.0 [1]
N-[[3-[(2-Amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]acetamideIC5086.0 [1]
Items per page: 1 - 10 of 83
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References

This online tool may be cited as follows

MLA

"Quest Database™ 6-O-methylguanine-DNA methyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/6-o-methylguanine-dna-methyltransferase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ 6-O-methylguanine-DNA methyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/6-o-methylguanine-dna-methyltransferase-inhibitors-ic50-ki.
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