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5-lipoxygenase/FLAP Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3-(3-(Tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acidIC5030.0 [1], 340.0 [2]
QuiflaponIC50200.0 [1], 8000.0 [2]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(pyridin-3-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC501090.0 [1], 17000.0 [2]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-[(6-chloropyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acidIC50110.0 [1], 17000.0 [2]
3-[5-(1,3-Benzothiazol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]indol-2-yl]-2,2-dimethylpropanoic acidIC50360.0 [1], 10000.0 [2]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(1,3-thiazol-4-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC5040.0 [1], 4000.0 [2]
2-[(E)-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropylidene]amino]oxyacetic acidIC50100.0 [1], 680.0 [2]
(E)-3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-N-methoxy-2,2-dimethylpropan-1-imineIC50340.0 [1], 11000.0 [2]
(NE)-N-[3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropylidene]hydroxylamineIC50270.0 [1], 2200.0 [2]
1-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropyl]-1-hydroxyureaIC50170.0 [1], 1600.0 [2]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(naphthalen-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC504420.0 [1], 12000.0 [2]
2-[(E)-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-[(6-chloropyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropylidene]amino]oxyacetic acidIC50230.0 [1], 10000.0 [2]
2-[(E)-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(pyridin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropylidene]amino]oxyacetic acidIC50600.0 [1], 13000.0 [2]
2-[(E)-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(1,3-thiazol-4-ylmethoxy)indol-2-yl]-2,2-dimethylpropylidene]amino]oxyacetic acidIC50180.0 [1], 11000.0 [2]
[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropyl]ureaIC50180.0 [1], 970.0 [2]
2-[(E)-[3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropylidene]amino]oxyacetic acidIC50600.0 [1], 12000.0 [2]
3-[1-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2-methylpropan-2-yl]-1-hydroxy-1-methylureaIC50150.0 [1], 1300.0 [2]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(pyridin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC5050.0 [1]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(pyridin-4-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC50840.0 [1]
3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(1,3-thiazol-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC507000.0 [1]
Items per page: 1 - 10 of 20
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References

This online tool may be cited as follows

MLA

"Quest Database™ 5-lipoxygenase/FLAP Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/5-lipoxygenase-flap-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ 5-lipoxygenase/FLAP Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/5-lipoxygenase-flap-inhibitors-ic50-ki.
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