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3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 46215815IC5010.0 [1]
Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-IC505.0 [1], 6.0 [2], 9.0 [3], 100.0 [4]
N-[3-[[5-Bromo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamideIC502.3 [1], 9.5 [2], 11.0 [3], 26.0 [4]
1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-phenylpyrrolidin-1-yl]ethanoneIC50200.0 [1], 300.0 [2], 320.0 [3]
1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-phenylpyrrolidin-1-yl]ethanoneKi1.4 [1]
2,2-Difluoro-N-[3-[6-(2-methylmorpholin-4-yl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamideIC5090.0 [1], 94.0 [2], 159.0 [3]
2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropane-1-carboxamideIC5080.0 [1], 143.0 [2]
(2S,5R)-4-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methyl-N-phenylmorpholine-2-carboxamideIC505.01 [1], 264.0 [2], 594.0 [3], 29300.0 [4]
(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamideIC503.16 [1], 327.0 [2], 333.0 [3], 29300.0 [4]
(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehydeIC5050.0 [1], 70.0 [2], 120.0 [3]
(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehydeKi0.7 [1]
1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanoneIC5070.0 [1], 80.0 [2], 160.0 [3]
1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanoneKi1.4 [1]
CelecoxibIC5048000.0 [1]
N'-[3-[[5-Bromo-2-[3-(pyrrolidine-1-carbonylamino)anilino]pyrimidin-4-yl]amino]propyl]-2,2-dimethylpropanediamideIC5030.0 [1], 39.0 [2]
4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)pyrimidin-2-amineIC505900.0 [1], 10000.0 [2]
10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamineIC5060.0 [1]
N-[3-(6-Morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropanecarboxamideIC50200.0 [1], 229.0 [2], 283.0 [3]
4,4-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclohexane-1-carboxamideIC50200.0 [1], 265.0 [2], 304.0 [3]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4,4-difluorocyclohexane-1-carboxamideIC50400.0 [1], 410.0 [2], 1500.0 [3]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropanecarboxamideIC501200.0 [1], 1230.0 [2], 1740.0 [3]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-2,2-difluorocyclopropane-1-carboxamideIC50280.0 [1], 300.0 [2], 1940.0 [3]
2,2-Difluoro-N-[3-[6-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamideIC501200.0 [1], 1220.0 [2], 3750.0 [3]
2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-4-yl]cyclopropane-1-carboxamideIC50385.0 [1], 400.0 [2], 4400.0 [3]
1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-cyclopropylureaIC50900.0 [1], 920.0 [2], 11600.0 [3]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-3-fluorobenzamideIC508790.0 [1], 8800.0 [2], 21100.0 [3]
3-(1H-Benzo[d]imidazol-2-yl)-5-(3-(methylsulfonyl)phenyl)-1H-indazoleIC5015300.0 [1], 23700.0 [2]
3-(1H-Benzo[d]imidazol-2-yl)-5-(3-(trifluoromethyl)phenyl)-1H-indazoleIC5030300.0 [1], 55700.0 [2]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-1,4-dimethylpiperidine-4-carboxamideIC5012400.0 [1], 100000.0 [2]
1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-cyclopentylureaIC5053900.0 [1], 100000.0 [2]
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamideIC501.58 [1], 165.0 [2], 655.0 [3]
Tert-butyl N-[(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl]carbamateIC506.31 [1], 74.0 [2], 151.0 [3]
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-5-ethyl-N-phenylmorpholine-2-carboxamideIC503.16 [1], 57.0 [2], 88.0 [3]
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-5-methylmorpholine-2-carboxamideIC503.16 [1], 24.0 [2], 30.0 [3]
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-5-ethylmorpholine-2-carboxamideIC506.31 [1], 85.0 [2], 102.0 [3]
N-[(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N,3,3-trimethylbutanamideIC500.63 [1], 22.0 [2], 116.0 [3]
(3R,6S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamideIC501258.93 [1], 29300.0 [2]
(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamideIC507.94 [1], 316.0 [2], 472.0 [3]
Tert-butyl N-[(3R,5R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N-methylcarbamateIC500.79 [1], 9.0 [2], 19.0 [3]
2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)ethanolIC502.6 [1], 4.7 [2]
4-N-(3-Fluorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC5034.0 [1], 280.0 [2]
4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(2-phenylpropan-2-yl)pyrimidin-2-amineIC5065.0 [1], 140.0 [2]
4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(1-phenylcyclopropyl)pyrimidin-2-amineIC5059.5 [1], 110.0 [2]
2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)ethanolIC5013.0 [1], 250.0 [2]
(2S)-3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-4-methoxyanilino)propane-1,2-diolIC5024.0 [1], 6800.0 [2]
4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(1-phenylcyclopentyl)pyrimidin-2-amineIC50130.0 [1], 625.0 [2]
4-[1-(4-Chlorophenyl)cyclopentyl]-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC50870.0 [1], 1400.0 [2]
4-N-(3-Chlorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC5051.0 [1], 200.0 [2]
4-N-(2-Fluorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC509.7 [1], 27.0 [2]
4-N-(2-Chlorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC507.6 [1], 26.0 [2]
4-N-Methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamineIC5016.5 [1], 800.0 [2]
4-N-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamineIC5012.0 [1], 690.0 [2]
4-N-(4-Chlorophenyl)-4-N-ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC5046.0 [1], 120.0 [2]
4-N-Benzyl-4-N-ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC5051.0 [1], 530.0 [2]
2-(N-[2-Amino-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)ethanolIC5017.0 [1], 2100.0 [2]
4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC50200.0 [1], 10000.0 [2]
4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC505900.0 [1], 10000.0 [2]
4-N-(2-Chlorophenyl)-4-N-methyl-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC5030.0 [1], 400.0 [2]
4-N-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-(1,3,4-thiadiazol-2-yl)pyrimidine-2,4-diamineIC50155.0 [1], 10000.0 [2]
1-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)-3-methoxypropan-2-olIC5011.0 [1], 520.0 [2]
3-[[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-(2,3-dihydroxypropyl)amino]benzonitrileIC5090.0 [1], 10000.0 [2]
3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)propanoic acidIC504.8 [1], 10000.0 [2]
2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2,4-difluoroanilino)ethanolIC506.5 [1], 35.0 [2]
2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-fluoroanilino)ethanolIC505.0 [1], 23.0 [2]
4-(2,3-Dihydro-1,4-benzoxazin-4-yl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC505.0 [1], 10000.0 [2]
4-N-(3-Fluorophenyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-(2-morpholin-4-ylethyl)pyrimidine-2,4-diamineIC5089.0 [1], 9700.0 [2]
4-N-(2-Chlorophenyl)-4-N-(2-methoxyethyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamineIC507.0 [1], 25.5 [2]
3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propanenitrileIC507.1 [1], 7.9 [2]
4-N-(3-Aminopropyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamineIC508.7 [1], 6800.0 [2]
3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propanamideIC5017.0 [1], 23000.0 [2]
4-[1-(2-Fluorophenyl)cyclopropyl]-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC5020.0 [1], 45.5 [2]
N-[3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propyl]acetamideIC5022.0 [1], 430.0 [2]
N-(3-Fluorophenyl)-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-amineIC50190.0 [1], 660.0 [2]
StaurosporineIC505.2 [1], 10.0 [2]
PDK1 inhibitor AR-12IC505000.0 [1]
(Z)-3-((1H-Pyrrol-2-yl)methylene)indolin-2-oneIC50520.0 [1], 1800.0 [2]
2-(4-(8-(2-(Pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrileIC5034.0 [1]
N-Methyl-1(R)-aminoindanIC50200.0 [1]
[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-5-yl]ureaIC5018.0 [1], 3000.0 [2]
4-[2-(3-Chloroanilino)-7H-purin-6-yl]phenolIC501600.0 [1]
6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-AmineIC50370.0 [1], 398.11 [2]
1-(3-Aminopropyl)-8-[3-[2-(dimethylamino)-2-oxoethyl]anilino]-N-[(2-methylpyridin-4-yl)methyl]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5085.0 [1]
(10E)-13-Methyl-7-oxa-13,20,22,24,26,28-hexazapentacyclo[19.6.1.12,6.115,19.023,27]triaconta-1(27),2(30),3,5,10,15(29),16,18,21(28),22,24-undecaeneIC50390.0 [1]
2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[(3Z)-3-(1H-imidazol-5-ylmethylidene)-2-oxo-1H-indol-5-yl]acetamideIC50980.0 [1], 998.0 [2]
2-[4-[5-Phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]guanidineIC502000.0 [1]
3-(6-Ethylpyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridineIC5010000.0 [1], 30000.0 [2]
3-(1H-Benzo[d]imidazol-2-yl)-5-bromo-1H-indazoleIC5010900.0 [1]
2,2-Difluoro-N-[3-[6-(4-methylpiperidin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamideIC50780.0 [1], 800.0 [2]
1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-(2,4-difluorophenyl)ureaIC50100000.0 [1]
N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-1-pyridin-4-ylpiperidine-4-carboxamideIC50100000.0 [1]
2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-6-yl]cyclopropane-1-carboxamideIC50100000.0 [1]
4-Butyl-6-(1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-AmineIC501100.0 [1], 10000.0 [2]
4-Ethyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamineIC501200.0 [1], 30000.0 [2]
4-Pentyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineIC502200.0 [1], 30000.0 [2]
4-(3-Aminopropyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineIC50390.0 [1], 30000.0 [2]
4-(4-Aminobutyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineIC501000.0 [1], 30000.0 [2]
4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-ethylpyrimidin-2-amineIC50480.0 [1], 30000.0 [2]
4-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amineIC5085.0 [1], 11000.0 [2]
4-Ethyl-6-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineIC50500.0 [1], 30000.0 [2]
4-Ethyl-6-(5-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineIC50450.0 [1], 30000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ 3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/3-phosphoinositide-dependent-protein-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ 3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/3-phosphoinositide-dependent-protein-kinase-1-inhibitors-ic50-ki.
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