3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Finasteride	Ki	11000.0 [1]
	Methyl (1S,9aR,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylate	Ki	12.0 [1]
	(1S,9Ar,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	150.0 [1]
	(1S,9Ar,11aS)-N-[bis(4-chlorophenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	510.0 [1]
	(1S,9Ar,11aS)-9a,11a-dimethyl-1-(morpholine-4-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-one	Ki	190.0 [1]
	2-Adamantyl (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylate	Ki	180.0 [1]
	(1S,9Ar,11aS)-6-chloro-N-(4-chlorophenyl)-N-cyclopentyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	490.0 [1]
	(1S,9Ar,11aS)-N-(4-chlorophenyl)-N-cyclopentyl-6,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	160.0 [1]
	(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	10.0 [1]
	(1S,9Ar,11aS)-N-(3,5-ditert-butylphenyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	7.8 [1]
	CID 44275674	Ki	1600.0 [1]
	(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-(2,4,4-trimethylpentan-2-yl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	IC50	150.0 [1]
	(1S,9Ar,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-6-chloro-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	190.0 [1]
	(1S,9Ar,11aS)-N-(3,3-dimethylbutyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	IC50	8.3 [1]
	(1S,9Ar,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-6,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamide	Ki	19.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 15 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/3-beta-hydroxysteroid-dehydrogenase-delta-5-4-isomerase-type-i-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/3-beta-hydroxysteroid-dehydrogenase-delta-5-4-isomerase-type-i-inhibitors-ic50-ki.
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