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26S proteasome Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
BortezomibIC502.56 [1], 7.0 [2], 7.14 [3], 120.0 [4], 2000.0 [5]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[3-phenylmethoxy-2-(phenylmethoxymethyl)propyl]pentanediamideIC505.1 [1], 75.0 [2], 2400.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]pentanediamideIC505.7 [1], 76.0 [2], 2500.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[5-phenylmethoxy-4-(phenylmethoxymethyl)pentyl]butanediamideIC504.1 [1], 120.0 [2], 2700.0 [3]
(2S)-2-Benzamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]butanediamideIC507.8 [1], 130.0 [2], 2700.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[3-phenylmethoxy-2-(phenylmethoxymethyl)propyl]butanediamideIC503.9 [1], 140.0 [2], 1100.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]butanediamideIC502.7 [1], 150.0 [2], 2700.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-(4-phenylmethoxybutyl)butanediamideIC504.8 [1], 170.0 [2], 2170.0 [3]
(2S)-N-[(1R)-3-Methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]-2-(pyrazine-2-carbonylamino)butanediamideIC507.1 [1], 210.0 [2], 3300.0 [3]
(2S)-2-[(2,5-Dichlorobenzoyl)amino]-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]butanediamideIC505.9 [1], 250.0 [2], 10000.0 [3]
(2S)-2-Acetamido-N'-methyl-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]butanediamideIC5054.0 [1], 500.0 [2], 10000.0 [3]
(2S)-N-[(1R)-3-Methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]-2-[(6-phenylpyridine-2-carbonyl)amino]butanediamideIC507.5 [1], 1000.0 [2], 10000.0 [3]
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-N'-[5-phenylmethoxy-4-(phenylmethoxymethyl)pentyl]pentanediamideIC504.1 [1], 46.0 [2], 3000.0 [3]
Belactosin AIC501400.0 [1], 1440.0 [2]
Benzyl N-[(2S)-1-[[(2R)-1-[(1R,2S)-2-[[(2R,3S)-3-[(2S)-butan-2-yl]-4-oxooxetane-2-carbonyl]amino]cyclopropyl]-4-phenylbutan-2-yl]amino]-1-oxopropan-2-yl]carbamateIC505.7 [1]
(2R,3S)-3-[(2S)-Butan-2-yl]-4-oxo-N-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]oxetane-2-carboxamideIC5029.0 [1]
CarfilzomibIC508.6 [1]
(2S)-2-Acetamido-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-N'-[4-phenylmethoxy-3-(phenylmethoxymethyl)butyl]butanediamideIC502300.0 [1]
(2S)-2-Acetamido-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-N'-(4-phenylmethoxybutyl)butanediamideIC505700.0 [1]
[(1R)-1-[[(2S)-2-Acetamido-4-oxo-4-[[3-phenylmethoxy-2-(phenylmethoxymethyl)propyl]amino]butanoyl]amino]-3-methylbutyl]boronic acidIC507.7 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]pyridine-3-carboxamideIC50340.0 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]benzamideIC50440.0 [1]
4-Fluoro-N-[3-[[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]benzamideIC50380.0 [1]
4-Methoxy-N-[3-[[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]benzamideIC50340.0 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]-4-(trifluoromethyl)benzamideIC50220.0 [1]
4-Cyano-N-[3-[[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]benzamideIC50360.0 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]naphthalene-2-carboxamideIC50190.0 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]thiophene-2-carboxamideIC50950.0 [1]
N-[3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]oxane-4-carboxamideIC50630.0 [1]
N-[(1R)-3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]-4-(trifluoromethyl)benzamideIC50170.0 [1]
N-[(1R)-3-[[(2S)-1-[[(2S)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-oxo-1-phenylpropyl]naphthalene-2-carboxamideIC50110.0 [1]
N-[(2S)-1-[[(1S)-3-Methyl-1-(2-oxo-1,3,4-oxathiazol-5-yl)butyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamideIC50108000.0 [1]
N-[(2S)-1-[[(1R)-3-Methyl-1-(2-oxo-1,3,4-oxathiazol-5-yl)butyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamideIC50225000.0 [1]
Items per page: 1 - 10 of 33
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References

This online tool may be cited as follows

MLA

"Quest Database™ 26S proteasome Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Dec. 2024, https://www.aatbio.com/data-sets/26s-proteasome-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 20). Quest Database™ 26S proteasome Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/26s-proteasome-inhibitors-ic50-ki.
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