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2-acylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(4-Tert-butylphenyl)-5-[(4-fluoro-2-methoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50168.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-fluoro-4-methoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50164.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-fluoro-4-pentoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50147.0 [1]
N-(4-Methoxyphenyl)-4-(4-methylphenyl)-6-oxo-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridine-5-carboxamideIC507.0 [1], 15.0 [2]
5-(2-Ethyltetrazol-5-yl)-4-(4-methylphenyl)-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridin-6-oneIC50121.0 [1], 33330.0 [2]
(2S)-4-(4-Methylphenyl)-6-oxo-N-[4-(2H-tetrazol-5-yl)phenyl]-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridine-5-carboxamideIC507.0 [1], 9.0 [2]
(2S)-4-(4-Methylphenyl)-N-(1,2-oxazol-5-yl)-6-oxo-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridine-5-carboxamideIC502.0 [1], 8.0 [2]
2-[1-(6-Tert-butylpyridin-3-yl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5013.0 [1], 29.0 [2]
2-(4-Tert-butylcyclohexanecarbonyl)-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5088.0 [1], 292.0 [2]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,3-dihydroisoindole-5-sulfonamideIC502120.0 [1]
5-[(4-Butoxy-2-fluorophenyl)sulfamoyl]-N-(4-tert-butylphenyl)-1,3-dihydroisoindole-2-carboxamideIC50547.0 [1]
N-(4-Tert-butylphenyl)-5-[(4-ethoxy-2-fluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC505200.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-chloro-4-fluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC501110.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-ethyl-4-fluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC502490.0 [1]
N-(4-Tert-butylphenyl)-5-[(2,4-difluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50685.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-ethoxy-4-fluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50733.0 [1]
N-[(1R)-1-[4-[(3,4-Dihydro-2H-1,4-benzoxazin-3-ylmethylamino)methyl]phenyl]ethyl]methanesulfonamide;hydrochlorideIC50479.0 [1]
N-[(1R)-1-[4-[[(1-Phenylpyrrolidin-3-yl)amino]methyl]phenyl]ethyl]methanesulfonamide;hydrochlorideIC50105.0 [1]
(3S)-N-(2,4-Difluorophenyl)-3-ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC501522.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-fluoro-4-propoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC501980.0 [1]
N-(4-Tert-butylphenyl)-5-[(2,4-dimethoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC503160.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-7-sulfonamideIC503060.0 [1]
N-(4-Tert-butylphenyl)-5-[(4-fluorophenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50594.0 [1]
2-[2-(4-Tert-butylphenyl)acetyl]-N-(4-fluorophenyl)-1,3-dihydroisoindole-5-sulfonamideIC508070.0 [1]
N-(4-Tert-butylphenyl)-5-[(4-fluoro-2-propoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC502300.0 [1]
2-(4-Tert-butylbenzoyl)-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50211.0 [1]
2-[(1-Tert-butylpyrazol-4-yl)methyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5092.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(1-propan-2-ylpyrazol-4-yl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50180.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[1-(cyclopropylmethyl)pyrazol-4-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50234.0 [1]
2-[(1-Cyclobutylpyrazol-4-yl)methyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50142.0 [1]
2-[(1-Tert-butylpyrazol-4-yl)methyl]-N-[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50198.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5028.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(2-fluoro-4-heptylphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5035.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[4-(3-cyclohexylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5062.0 [1]
2-[(6-Tert-butylpyridin-3-yl)methyl]-N-[2-fluoro-4-(3-phenylpropoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50218.0 [1]
2-[(6-Tert-butylpyridin-3-yl)methyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50135.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-(5-phenylpentyl)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5053.0 [1]
N-(2-Fluoro-4-hexoxyphenyl)-2-[2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]ethyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50214.0 [1]
2-[(6-Tert-butylpyridin-3-yl)methyl]-N-(2-fluoro-4-heptylphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5031.0 [1]
2-[(6-Tert-butylpyridin-3-yl)methyl]-N-[2-fluoro-4-(5-phenylpentoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5036.0 [1]
2-[(6-Tert-butylpyridin-3-yl)methyl]-N-[4-(3-cyclohexylpropoxy)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5065.0 [1]
2-[2-(6-Tert-butylpyridin-3-yl)ethyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50258.0 [1]
2-[2-(6-Tert-butylpyridin-3-yl)ethyl]-N-[2-fluoro-4-(3-phenylpropoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50286.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50180.0 [1]
2-[2-(5-Tert-butylpyrimidin-2-yl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5040.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5051.0 [1]
2-[(4-Tert-butylphenyl)methyl]-N-[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50203.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50228.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(1-ethylpyrazol-4-yl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50182.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50248.0 [1]
2-[(2-Tert-butylpyridin-4-yl)methyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5071.0 [1]
2-[(2-Tert-butyl-1,3-thiazol-5-yl)methyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50195.0 [1]
N-(2-Fluoro-4-heptylphenyl)-2-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50134.0 [1]
N-(2-Fluoro-4-heptylphenyl)-2-hexyl-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50220.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(4-propan-2-yloxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50199.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[4-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50273.0 [1]
2-[(5-Tert-butylpyrazin-2-yl)methyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50233.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(4-methyl-2-phenyl-1,3-thiazol-5-yl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50118.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(5-methyl-1-phenylpyrazol-4-yl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5081.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5057.0 [1]
2-[[2-(4-Chlorophenyl)-1,3-thiazol-5-yl]methyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50105.0 [1]
N-[4-(3-Cyclopentylpropyl)-2-fluorophenyl]-2-[[1-(4-methylphenyl)pyrazol-4-yl]methyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5016.0 [1]
2-[2-(1-Tert-butylpyrazol-4-yl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50140.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-(3-phenylpropoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50173.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50133.0 [1]
N-[4-[3-(Benzenesulfonyl)propoxy]-2-fluorophenyl]-2-[2-(4-tert-butylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5035.0 [1]
2-[(2-Tert-butylpyridin-4-yl)methyl]-N-[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50235.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[2-(oxan-2-ylmethoxy)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50178.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[2-(oxolan-2-ylmethoxy)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50160.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[2-[(3S,4R)-3-fluorooxan-4-yl]ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50169.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[3-(2,2,2-trifluoroethoxy)propoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50158.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[4-(2-cyclohexyloxyethoxy)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50137.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[4-(3-cyclopentyloxypropoxy)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5068.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[2-[(3R,4R)-3-fluorooxan-4-yl]ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50204.0 [1]
2-[2-(5-Tert-butylpyrazin-2-yl)ethyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50212.0 [1]
2-[2-(5-Tert-butylpyrimidin-2-yl)ethyl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50164.0 [1]
2-[1-(4-Tert-butylphenyl)propan-2-yl]-N-(2-fluoro-4-hexoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5039.0 [1]
2-[1-(4-Tert-butylphenyl)propan-2-yl]-N-(2-fluoro-4-heptylphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5062.0 [1]
2-[1-(4-Tert-butylphenyl)propan-2-yl]-N-(2-fluoro-4-octoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5097.0 [1]
2-[1-(4-Tert-butylphenyl)propan-2-yl]-N-[4-(3-cyclohexylpropoxy)-2-fluorophenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50106.0 [1]
2-[1-(4-Tert-butylphenyl)propan-2-yl]-N-[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5068.0 [1]
2-[1-(6-Tert-butylpyridin-3-yl)ethyl]-N-[2-fluoro-4-(3-phenylpropoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50121.0 [1]
2-[1-(4-Tert-butylphenyl)propyl]-N-[2-fluoro-4-(3-phenylpropoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC50235.0 [1]
N-(4-Butylphenyl)-6-[(2-fluoro-4-hexoxyphenyl)sulfamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC5076.0 [1]
N-(4-Tert-butylphenyl)-6-[(2-fluoro-4-hexoxyphenyl)sulfamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC5098.0 [1]
N-(4-Tert-butylphenyl)-5-[(2,4-difluoro-6-methoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50193.0 [1]
N-(4-Tert-butylphenyl)-6-[[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]sulfamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC50178.0 [1]
N-Cyclohexyl-6-[[4-(3-cyclopentylpropyl)-2-fluorophenyl]sulfamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC5069.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-(2-fluoro-4-octoxyphenyl)-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5045.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-(5-phenylpentoxy)phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5024.0 [1]
2-[2-(4-Tert-butylphenyl)ethyl]-N-[2-fluoro-4-[2-(oxan-4-yl)ethoxy]phenyl]-3,4-dihydro-1H-isoquinoline-6-sulfonamideIC5079.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-fluoro-4-hexoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC5043.0 [1]
N-(4-Tert-butylphenyl)-5-[(2-fluoro-4-octoxyphenyl)sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC507.0 [1]
N-(4-Tert-butylphenyl)-5-[[4-(2-cyclohexylethoxy)-2-fluorophenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC5029.0 [1]
N-(4-Tert-butylphenyl)-5-[[4-(3-cyclohexylpropoxy)-2-fluorophenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC5026.0 [1]
N-(4-Tert-butylphenyl)-5-[[2-fluoro-4-(2-phenylethoxy)phenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50127.0 [1]
N-(4-Tert-butylphenyl)-5-[[2-fluoro-4-(3-phenylpropoxy)phenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC5056.0 [1]
N-(4-Tert-butylphenyl)-5-[[2-fluoro-4-(5-phenylpentoxy)phenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC5010.0 [1]
N-(4-Tert-butylphenyl)-5-[[2-fluoro-4-[2-(4-fluorophenoxy)ethoxy]phenyl]sulfamoyl]-1,3-dihydroisoindole-2-carboxamideIC50125.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ 2-acylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/2-acylglycerol-o-acyltransferase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ 2-acylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/2-acylglycerol-o-acyltransferase-2-inhibitors-ic50-ki.
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