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NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5*

NAADP is a calcium mobilizing agent. NAADP initiates calcium release via type 1 ryanodine receptor (RyR1) activation. NAADP also regulates calcium release from intracellular stores distinct from the endoplasmic reticulum (ER), and displays affinity for two-pore channels (TPCs), which release calcium from acidic organelles.

Calculators

Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM116.917 µL584.583 µL1.169 mL5.846 mL11.692 mL
5 mM23.383 µL116.917 µL233.833 µL1.169 mL2.338 mL
10 mM11.692 µL58.458 µL116.917 µL584.583 µL1.169 mL

Molarity calculator

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Citations

View all 1 citations: Citation Explorer
NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury
Authors: Rah, So-Young and Lee, Young-Hoon and Kim, Uh-Hyun
Journal: The FASEB Journal (2017): fj--201601290R

References

View all 149 references: Citation Explorer
Both RyRs and TPCs are required for NAADP-induced intracellular Ca release
Authors: Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.
Journal: Cell Calcium. (2015)
A novel Ca(2)(+)-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca(2)(+) signalling
Authors: Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F.
Journal: Cell Calcium (2015): 89
NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells
Authors: Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.
Journal: J Biol Chem. (2015)
The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption
Authors: Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.
Journal: Calcif Tissue Int (2015): 73
A primer of NAADP-mediated Ca signalling: From sea urchin eggs to mammalian cells
Authors: Galione A., undefined
Journal: Cell Calcium (2015): 27
Page updated on October 30, 2024

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Physical properties

Molecular weight

855.31

Solvent

Water

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

5502-96-5
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