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NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5*
NAADP is a calcium mobilizing agent. NAADP initiates calcium release via type 1 ryanodine receptor (RyR1) activation. NAADP also regulates calcium release from intracellular stores distinct from the endoplasmic reticulum (ER), and displays affinity for two-pore channels (TPCs), which release calcium from acidic organelles.
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Common stock solution preparation
Table 1. Volume of Water needed to reconstitute specific mass of NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 116.917 µL | 584.583 µL | 1.169 mL | 5.846 mL | 11.692 mL |
| 5 mM | 23.383 µL | 116.917 µL | 233.833 µL | 1.169 mL | 2.338 mL |
| 10 mM | 11.692 µL | 58.458 µL | 116.917 µL | 584.583 µL | 1.169 mL |
Molarity calculator
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Citations
View all 1 citations: Citation Explorer
NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury
Authors: Rah, So-Young and Lee, Young-Hoon and Kim, Uh-Hyun
Journal: The FASEB Journal (2017): fj--201601290R
Authors: Rah, So-Young and Lee, Young-Hoon and Kim, Uh-Hyun
Journal: The FASEB Journal (2017): fj--201601290R
References
View all 149 references: Citation Explorer
Both RyRs and TPCs are required for NAADP-induced intracellular Ca release
Authors: Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.
Journal: Cell Calcium. (2015)
Authors: Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.
Journal: Cell Calcium. (2015)
A novel Ca(2)(+)-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca(2)(+) signalling
Authors: Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F.
Journal: Cell Calcium (2015): 89
Authors: Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F.
Journal: Cell Calcium (2015): 89
NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells
Authors: Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.
Journal: J Biol Chem. (2015)
Authors: Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.
Journal: J Biol Chem. (2015)
The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption
Authors: Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.
Journal: Calcif Tissue Int (2015): 73
Authors: Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.
Journal: Calcif Tissue Int (2015): 73
A primer of NAADP-mediated Ca signalling: From sea urchin eggs to mammalian cells
Authors: Galione A., undefined
Journal: Cell Calcium (2015): 27
Authors: Galione A., undefined
Journal: Cell Calcium (2015): 27
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