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GTIF647 [iFluor® 647 gentamicin conjugate]
Gentamicin is widely used for treating tuberculosis and Gram-negative infections and is particularly useful in neonatal intensive care units. Fluorophore-tagged drugs, such as gentamicin- iFluor® 647 (GTIF647) conjugates, might be used to identify drug trafficking routes across the BLB and into hair cells, and specifically in the cochlea - the sensory organ responsible for hearing. Identifying the mechanisms involved in the intracochlear trafficking of ototoxic drugs to hair cells is of fundamental as well as clinical importance. GTIF647 is well excited with the popular red laser at 647 nm or HeNe laser at 632 nm. It provides researchers a valuable tool to study the cellular uptake, kinetics and distribution of gentamicin through fluorescence techniques, such as fluorescence microscopy, fluorescence correlation spectroscopy, single molecule spectroscopy. The iFluor® 647 is well compatible with the common Cy5 filter set.
Spectrum
References
View all 50 references: Citation Explorer
Fluorescence-Based Binding Characterization of Small Molecule Ligands Targeting CUG RNA Repeats.
Authors: Chang, Zhihua and Zheng, Ya Ying and Mathivanan, Johnsi and Valsangkar, Vibhav A and Du, Jinxi and Abou-Elkhair, Reham A I and Hassan, Abdalla E A and Sheng, Jia
Journal: International journal of molecular sciences (2022)
Authors: Chang, Zhihua and Zheng, Ya Ying and Mathivanan, Johnsi and Valsangkar, Vibhav A and Du, Jinxi and Abou-Elkhair, Reham A I and Hassan, Abdalla E A and Sheng, Jia
Journal: International journal of molecular sciences (2022)
Liquid chromatography-tandem mass spectrometry method for quantification of gentamicin and its individual congeners in serum and comparison results with two immunoanalytical methods (fluorescence polarization immunoassay and chemiluminiscent microparticle
Authors: Brozmanova, Hana and Urinovska, Romana and Safarcik, Kristian and Vsiansky, Frantisek and Kacirova, Ivana and Grundmann, Milan
Journal: Clinica chimica acta; international journal of clinical chemistry (2021): 191-198
Authors: Brozmanova, Hana and Urinovska, Romana and Safarcik, Kristian and Vsiansky, Frantisek and Kacirova, Ivana and Grundmann, Milan
Journal: Clinica chimica acta; international journal of clinical chemistry (2021): 191-198
Development of a green fluorescence protein (GFP)-based bioassay for detection of antibiotics and its application in milk.
Authors: Yazgan Karacaglar, Nazife Nur and Topcu, Ali and Dudak, Fahriye Ceyda and Boyaci, Ismail Hakki
Journal: Journal of food science (2020): 500-509
Authors: Yazgan Karacaglar, Nazife Nur and Topcu, Ali and Dudak, Fahriye Ceyda and Boyaci, Ismail Hakki
Journal: Journal of food science (2020): 500-509
Micronomicin/tobramycin binding with DNA: fluorescence studies using of ethidium bromide as a probe and molecular docking analysis.
Authors: Bi, Shuyun and Zhou, Huifeng and Wu, Jun and Sun, Xiaoyue
Journal: Journal of biomolecular structure & dynamics (2019): 1464-1476
Authors: Bi, Shuyun and Zhou, Huifeng and Wu, Jun and Sun, Xiaoyue
Journal: Journal of biomolecular structure & dynamics (2019): 1464-1476
Label-free and nicking enzyme-assisted fluorescence signal amplification for RNase H determination based on a G-quadruplexe/thioflavin T complex.
Authors: Wu, Kefeng and Ma, Changbei and Deng, Zhiyi and Fang, Ning and Tang, Zhenwei and Zhu, Xingxing and Wang, Kemin
Journal: Talanta (2018): 142-147
Authors: Wu, Kefeng and Ma, Changbei and Deng, Zhiyi and Fang, Ning and Tang, Zhenwei and Zhu, Xingxing and Wang, Kemin
Journal: Talanta (2018): 142-147
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