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Chrysamine G *CAS 6472-91-9*
Chrysamine G is a lipophilic, bis-salicylic acid analog of Congo Red that displays both high (Kd = 200 nM; Bmax = 1.13 moles per mole of Ab40) and low (Kd = 38.77 µM; Bmax = 23.10 moles per mole of Ab40) affinity binding sites for beta-amyloid (Ab) fibrils. It can cross the blood-brain barrier and serve as a useful probe for detecting senile plaques (Ab aggregate).
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Chrysamine G *CAS 6472-91-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 207.28 µL | 1.036 mL | 2.073 mL | 10.364 mL | 20.728 mL |
| 5 mM | 41.456 µL | 207.28 µL | 414.559 µL | 2.073 mL | 4.146 mL |
| 10 mM | 20.728 µL | 103.64 µL | 207.28 µL | 1.036 mL | 2.073 mL |
Molarity calculator
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| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Product family
| Name | Excitation (nm) | Emission (nm) |
| Sulforhodamine G *CAS 5873-16-5* | 531 | 552 |
References
View all 13 references: Citation Explorer
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
Authors: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.
Journal: J Biol Chem (2005): 5892
Authors: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.
Journal: J Biol Chem (2005): 5892
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
Authors: Mathis CA, Wang Y, Klunk WE.
Journal: Curr Pharm Des (2004): 1469
Authors: Mathis CA, Wang Y, Klunk WE.
Journal: Curr Pharm Des (2004): 1469
Amyloid binding ligands as Alzheimer's disease therapies
Authors: Lee VM., undefined
Journal: Neurobiol Aging (2002): 1039
Authors: Lee VM., undefined
Journal: Neurobiol Aging (2002): 1039
Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
Authors: Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.
Journal: Neurosci Lett (2002): 5
Authors: Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.
Journal: Neurosci Lett (2002): 5
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
Authors: Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.
Journal: J Neuropathol Exp Neurol (2002): 797
Authors: Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.
Journal: J Neuropathol Exp Neurol (2002): 797
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