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BAPTA Succinimidyl Ester

BAPTA Succinimidyl Ester is an excellent building block to introduce BAPTA calcium chelator into a biological molecule that contains an amino group such as antibodies, proteins, peptides and amino-modified oligos. BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a common calcium-specific chelator. The presence of four carboxylic acid functional groups makes BAPTA possibly binding two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions. BAPTA is commonly used to chelate Ca2+, similarly to EGTA.

References

View all 40 references: Citation Explorer
[Orexin-A inhibits γ-aminobutyric acid current of neonatal rat spinal cord ventral horn neurons by activating OX1R, OX2R and Ca2+-independent PKC].
Authors: Yang, X and Zhu, S and Jin, N and Li, Y and Zhen, C and Zhang, H and Xu, A and Wang, M and Zheng, C
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (2021): 694-701
Orexin A presynaptically decreases inhibitory synaptic transmission in rat locus coeruleus neurons.
Authors: Kargar, Hossein Mohammad-Pour and Azizi, Hossein and Mirnajafi-Zadeh, Javad and Mani, Ali Reza and Semnanian, Saeed
Journal: Neuroscience letters (2018): 89-93
The impact of calcium assay change on a local adjusted calcium equation.
Authors: Davies, Sarah L and Hill, Charlotte and Bailey, Lisa M and Davison, Andrew S and Milan, Anna M
Journal: Annals of clinical biochemistry (2016): 292-4
Calciuria determined by new NM-BAPTA calcium assay is not free from magnesium interference.
Authors: Brunel, Valéry and Wils, Julien
Journal: Clinica chimica acta; international journal of clinical chemistry (2015): 113-4
Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle.
Authors: Ainbinder, Alina and Boncompagni, Simona and Protasi, Feliciano and Dirksen, Robert T
Journal: Cell calcium (2015): 14-24
Page updated on April 15, 2025

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Catalog Number20421
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Physical properties

Molecular weight

772.76

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
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