ICG amine

Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. This ICG amine can be used to modify the molecules that contain a carbonyl group (such as an aldehyde or a carboxy group).

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of ICG amine to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	99.892 µL	499.461 µL	998.921 µL	4.995 mL	9.989 mL
5 mM	19.978 µL	99.892 µL	199.784 µL	998.921 µL	1.998 mL
10 mM	9.989 µL	49.946 µL	99.892 µL	499.461 µL	998.921 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
	/		=		x		=

Spectrum

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Product family

Name	Excitation (nm)	Emission (nm)	Extinction coefficient (cm ^-1 M ^-1)	Correction Factor (280 nm)
ICG-ATT [3-ICG-acyl-1,3-thiazolidine-2-thione]	789	813	230000	0.076
ICG-OSu	789	813	230000	0.076
XFD488 amine Same Structure to Alexa Fluor™ 488 amine	499	520	71000	0.11
XFD594 amine Same Structure to Alexa Fluor™ 594 amine	590	618	90000	0.56
XFD532 amine	534	553	81000	0.09
XFD555 amine	553	568	155000	0.08
XFD568 amine	579	603	91300	0.46
XFD647 amine	650	671	270000	0.03
XFD750 amine	752	776	290000	0.04
ICG-Osu UltraPure Grade	789	813	230000	0.076
XFD350 amine	343	441	19000	0.19
XFD405 amine	401	421	35,000	0.70
XFD430 amine	432	540	15,000	0.28
XFD514 amine	518	543	80000	0.18
XFD546 amine	561	572	112000	0.12
Show More (6)

Citations

View all 7 citations: Citation Explorer

Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker
Authors: Johansen, Mette L and Vincent, Jason and Rose, Marissa and Sloan, Andrew E and Brady-Kalnay, Susann M
Journal: Molecular Imaging and Biology (2023): 1--14

Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization
Authors: Cai, Wenting and Chen, Qijing and Shen, Tianyi and Yang, Qian and Hu, Weinan and Zhao, Peng and Yu, Jing
Journal: Biomaterials Science (2020): 4481--4491

Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging
Authors: Pak, Rebecca W and Le, Hanh ND and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2

Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging
Authors: Pak, Rebecca W and Le, Hanh and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2

Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
Authors: Zhao, Shuting and Xu, Zhaobin and Wang, Hai and Reese, Benjamin E and Gushchina, Liubov V and Jiang, Meng and Agarwal, Pranay and Xu, Jiangsheng and Zhang, Mingjun and Shen, Rulong and others, undefined
Journal: Nature Communications (2016): 13306

References

View all 193 references: Citation Explorer

Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer
Authors: Yuasa Y, Seike J, Yoshida T, Takechi H, Yamai H, Yamamoto Y, Furukita Y, Goto M, Minato T, Nishino T, Inoue S, Fujiwara S, Tangoku A.
Journal: Ann Surg Oncol (2012): 486

Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study
Authors: Yannuzzi LA, Slakter JS, Gross NE, Spaide RF, Costa DL, Huang SJ, Klancnik JM, Jr., Aizman A.
Journal: Retina (2012): 288

Using indocyanine green fluorescent lymphography and lymphatic-venous anastomosis for cancer-related lymphedema
Authors: Mihara M, Murai N, Hayashi Y, Hara H, Iida T, Narushima M, Todokoro T, Uchida G, Yamamoto T, Koshima I.
Journal: Ann Vasc Surg (2012): 278 e1

Indocyanine green fluorescence endoscopy for visual differentiation of pituitary tumor from surrounding structures
Authors: Litvack ZN, Zada G, Laws ER, Jr.
Journal: J Neurosurg. (2012)

Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs
Authors: Jung B, Anvari B.
Journal: Biotechnol Prog (2012): 533

Page updated on November 27, 2024

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Unit size	1 mg 5 mg
Catalog Number	188188-5MG
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Physical properties

Molecular weight	1001.08
Solvent	DMSO

Spectral properties

Correction Factor (280 nm)	0.076
Extinction coefficient (cm ^-1 M ^-1)	230000
Excitation (nm)	789
Emission (nm)	813

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501